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- Broström, Göran, et al.
(författare)
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Social class and sex-specific adult mortality during 200 years in Sweden
- 2019
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Konferensbidrag (refereegranskat)abstract
- Recent regional studies on adult mortality and socio-economic status inSweden are merged and also completed with analyses from country-widecensuses in strategic time periods, with the purpose to find out whetherthe locally drawn conclusions about a changing social gradient in mortalitystill holds.The answer is firmly positive: While the upper classes have definiteadvantage in modern time (after, say, the 1960s), the reverse situationholds during the nineteenth and early twentieth century for men. Women, onthe other hand, seem to follow the expected pattern of a positive socialgradient through the last 200 years.
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- Bygren, Lars Olov, 1936-, et al.
(författare)
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Change in paternal grandmothers' early food supply influenced cardiovascular mortality of the female grandchildren
- 2014
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Ingår i: BMC Genetics. - : BioMed Central. - 1471-2156. ; 15, s. 12-
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Tidskriftsartikel (refereegranskat)abstract
- Background: This study investigated whether large fluctuations in food availability during grandparents' early development influenced grandchildren's cardiovascular mortality. We reported earlier that changes in availability of food - from good to poor or from poor to good - during intrauterine development was followed by a double risk of sudden death as an adult, and that mortality rate can be associated with ancestors' childhood availability of food. We have now studied transgenerational responses (TGR) to sharp differences of harvest between two consecutive years' for ancestors of 317 people in Overkalix, Sweden. Results: The confidence intervals were very wide but we found a striking TGR. There was no response in cardiovascular mortality in the grandchild from sharp changes of early exposure, experienced by three of the four grandparents (maternal grandparents and paternal grandfathers). If, however, the paternal grandmother up to puberty lived through a sharp change in food supply from one year to next, her sons' daughters had an excess risk for cardiovascular mortality (HR 2.69, 95% confidence interval 1.05-6.92). Selection or learning and imitation are unlikely explanations. X-linked epigenetic inheritance via spermatozoa seemed to be plausible, with the transmission, limited to being through the father, possibly explained by the sex differences in meiosis. Conclusion: The shock of change in food availability seems to give specific transgenerational responses.
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- Bygren, Lars Olov, 1936-, et al.
(författare)
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Epigenetics or ephemeral genetics? : Reply to Senn
- 2006
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Ingår i: European Journal of Human Genetics. - : Nature publishing group. - 1018-4813 .- 1476-5438.
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Annan publikation (övrigt vetenskapligt/konstnärligt)
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| 10. |
- Bygren, Lars Olov, 1936-, et al.
(författare)
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Longevity determined by parental ancestors' nutrition during their slow growth period
- 2001
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Ingår i: Acta Biotheoretica. - : Springer. - 0001-5342 .- 1572-8358. ; 49:1, s. 53-59
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Tidskriftsartikel (refereegranskat)abstract
- Social circumstances often impinge on later generations in a socio-economic manner, giving children an uneven start in life. Overfeeding and overeating might not be an exception. The pathways might be complex but one direct mechanism could be genomic imprinting and loss of imprinting. An intergenerational "feedforward" control loop has been proposed, that links grandparental nutrition with the grandchild's growth. The mechanism has been speculated to be a specific response, e.g. to their nutritional state, directly modifying the setting of the gametic imprint on one or more genes. This study raises the question: Can overnutrition during a child's slow growth period trigger such direct mechanisms and partly determine mortality? Data were collected by following-up a cohort born in 1905 in Överkalix parish, northernmost Sweden. The probands were characterised by their parents' or grandparents' access to food during their own slow growth period. Availability of food in the area was defined by referring to historical data on harvests and food prices, records of local community meetings and general historical facts.If there was a surfeit of food in the environment when the paternal grandfather was a 9–12 year old boy a shortening of the proband survival could be demonstrated. The influence of parents', maternal grandparents' and paternal grandmothers' access to food during their slow growth period was discounted in a multivariable analysis. The results are indicative of very early programming mechanisms in human adaptation to the social environment.
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