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- Eide, M.H., et al.
(författare)
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Life cycle assessment (LCA) of cleaning-in-place processes in dairies
- 2003
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Ingår i: Lebensmittel-Wissenschaft + Technologie. - 0023-6438 .- 1096-1127. ; 36:3, s. 303-314
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Tidskriftsartikel (refereegranskat)abstract
- Four Cleaning-In-Place (CIP) methods for dairies were compared using life cycle assessment (LCA). The methods were conventional alkaline/acid cleaning with hot water disinfection, one-phase alkaline cleaning with acid chemical disinfection, enzyme-based cleaning with acid chemical disinfection and the conventional method with disinfection by cold nitric acid at pH 2. Production of detergents, transport, the user phase in the dairy and waste management of containers were included. The user phase was found to be the most important part of the life cycle. The CIP methods with small volumes and low temperatures, such as enzyme-based cleaning and one-phase alkaline cleaning, turned out to be the best alternatives for the impact categories energy use, global warming, acidification, eutrophication and photo-oxidant formation. Milk residues flushed out in the rinsing phase were the main contributor to eutrophication, but the phosphorus and nitrogen in the detergents also influenced the results. Evaluation of toxic substances poses a methodological problem in LCA. In this study, detergents partly composed of toxic substances were included, and the overall assessment was that the one-phase alkaline cleaning method was preferable from an environmental point of view. A qualitative assessment of toxicity was performed. © 2003 Published by Elsevier Science Ltd. on behalf of Swiss Society of Food Science and Technology.
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| 2. |
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| 3. |
- Eide, P. K., et al.
(författare)
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Plasma neurodegeneration biomarker concentrations associate with glymphatic and meningeal lymphatic measures in neurological disorders
- 2023
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Ingår i: Nature Communications. - 2041-1723. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Clearance of neurotoxic brain proteins via cerebrospinal fluid (CSF) to blood has recently emerged to be crucial, and plasma biomarkers of neurodegeneration were newly introduced to predict neurological disease. This study examines in 106 individuals with neurological disorders associations between plasma biomarkers [40 and 42 amino acid-long amyloid-beta (A beta 40 and A beta 42), total-tau, glial fibrillary acidic protein (GFAP), and neurofilament light (NfL)] and magnetic resonance imaging measures of CSF-mediated clearance from brain via extra-vascular pathways (proxy of glymphatic function) and CSF-to-blood clearance variables from pharmacokinetic modeling (proxy of meningeal lymphatic egress). We also examine how biomarkers vary during daytime and associate with subjective sleep quality. Plasma concentrations of neurodegeneration markers associate with indices of glymphatic and meningeal lymphatic functions in individual- and disease-specific manners, vary during daytime, but are unaffected by sleep quality. The results suggest that plasma concentrations of neurodegeneration biomarkers associate with measures of glymphatic and meningeal lymphatic function. Plasma neurodegeneration biomarkers are increasingly utilized to predict neurological disease. Here, authors show in different neurological disorders associations between plasma neurodegeneration biomarker concentrations and various measures of glymphatic and meningeal lymphatic functions.
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| 4. |
- Fenstad, M H, et al.
(författare)
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STOX2 but not STOX1 is differentially expressed in decidua from pre-eclamptic women : data from the Second Nord-Trondelag Health Study
- 2010
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Ingår i: Molecular human reproduction. - : Oxford University Press (OUP). - 1360-9947 .- 1460-2407. ; 16:12, s. 960-968
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Tidskriftsartikel (refereegranskat)abstract
- Variation in the Storkhead box-1 (STOX1) gene has previously been associated with pre-eclampsia. In this study, we assess candidate single nucleotide polymorphisms (SNPs) in STOX1 in an independent population cohort of pre-eclamptic (n = 1.139) and non-pre-eclamptic (n = 2.269) women (the HUNT2 study). We also compare gene expression levels of STOX1 and its paralogue, Storkhead box-2 (STOX2) in decidual tissue from pregnancies complicated by pre-eclampsia and/or fetal growth restriction (FGR) (n = 40) to expression levels in decidual tissue from uncomplicated pregnancies (n = 59). We cannot confirm association of the candidate SNPs to pre-eclampsia (P > 0.05). For STOX1, no differential gene expression was observed in any of the case groups, whereas STOX2 showed significantly lower expression in deciduas from pregnancies complicated by both pre-eclampsia and FGR as compared with controls (P = 0.01). We further report a strong correlation between transcriptional alterations reported previously in choriocarcinoma cells over expressing STOX1A and alterations observed in decidual tissue of pre-eclamptic women with FGR.
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