| 1. |
- Einarsson, Jan, et al.
(författare)
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Barns språk i klassamhälle
- 2000
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Ingår i: Barns språkliga dagar. - 9789144049595
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Bokkapitel (refereegranskat)
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| 2. |
- Einarsson, Jan, et al.
(författare)
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Inledning
- 2003
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Ingår i: Första nationella konferensen i svenska med didaktisk inriktning : Växjö 8 - 9 januari 2003. - 9197472204
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 3. |
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| 4. |
- Jungebluth, Philipp, et al.
(författare)
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Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite : a proof-of-concept study
- 2011
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Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 378:9808, s. 1997-2004
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Tidskriftsartikel (refereegranskat)abstract
- Background Tracheal tumours can be surgically resected but most are an inoperable size at the time of diagnosis; therefore, new therapeutic options are needed. We report the clinical transplantation of the tracheobronchial airway with a stem-cell-seeded bioartificial nanocomposite. Methods A 36-year-old male patient, previously treated with debulking surgery and radiation therapy, presented with recurrent primary cancer of the distal trachea and main bronchi. After complete tumour resection, the airway was replaced with a tailored bioartificial nanocomposite previously seeded with autologous bone-marrow mononuclear cells via a bioreactor for 36 h. Postoperative granulocyte colony-stimulating factor filgrastim (10 mu g/kg) and epoetin beta (40 000 UI) were given over 14 days. We undertook flow cytometry, scanning electron microscopy, confocal microscopy epigenetics, multiplex, miRNA, and gene expression analyses. Findings We noted an extracellular matrix-like coating and proliferating cells including a CD105+ subpopulation in the scaffold after the reseeding and bioreactor process. There were no major complications, and the patient was asymptomatic and tumour free 5 months after trans plantation. The bioartificial nanocomposite has patent anastomoses, lined with a vascularised neomucosa, and was partly covered by nearly healthy epithelium. Post-operatively, we detected a mobilisation of peripheral cells displaying increased mesenchymal stromal cell phenotype, and upregulation of epoetin receptors, antiapoptotic genes, and miR-34 and miR-449 biomarkers. These findings, together with increased levels of regenerative-associated plasma factors, strongly suggest stem-cell homing and cell-mediated wound repair, extracellular matrix remodelling, and neovascularisation of the graft. Interpretation Tailor-made bioartificial scaffolds can be used to replace complex airway defects. The bioreactor reseeding process and pharmacological-induced site-specific and graft-specific regeneration and tissue protection are key factors for successful clinical outcome.
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| 5. |
- Amundadottir, Laufey T., et al.
(författare)
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A common variant associated with prostate cancer in European and African populations
- 2006
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Ingår i: Nature Genetics. - DeCODE Genet, IS-101 Reykjavik, Iceland. Univ Iceland, Landspitali Hosp, Dept Pathol, IS-101 Reykjavik, Iceland. Univ Iceland, Landspitali Hosp, Dept Urol, IS-101 Reykjavik, Iceland. Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA. Orebro Univ Hosp, Dept Urol & Clin Med, Orebro, Sweden. Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden. Univ Michigan, Dept Urol, Ann Arbor, MI 48109 USA. Northwestern Univ, Feinberg Sch Med, Dept Urol, Chicago, IL 60611 USA. Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA. Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA. Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA. : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 38:6, s. 652-658
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Tidskriftsartikel (refereegranskat)abstract
- With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.
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| 6. |
- Ask, Sofia, et al.
(författare)
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Mångfald och stadieövergångar
- 2004
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Ingår i: På väg mot integrativ didaktik. - Växjö : Växjö University Press. - 917636433X ; 53, s. 93-102
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Bokkapitel (refereegranskat)
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| 7. |
- Ask, Sofia, 1969-
(författare)
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Tillgång till framgång : Lärare och studenter om stadieövergången till högre utbildning
- 2005
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This essay discusses the advantages and disadvantages of co-ordinated subjects in Upper Secondary education, with focus on the implication such co-ordination has on writing skills. Through analysis of student essays, some conclusions are made concerning the justification of co-ordination of subjects. The essay describes the writing skills of Upper Secondary students and tries to evaluate if their writing skills in any way benefit from co-ordination of subjects.
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| 8. |
- Ask, Sofia, 1969-
(författare)
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Vägar till ett akademiskt skriftspråk
- 2007
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Abstract Ask, S., 2007: Vägar till ett akademiskt skriftspråk (Roads to academic written language). Acta Wexionensia nr 115/2007. ISBN: 978-91-7636-557-1 The overall aim of the dissertation is to analyse the general features of academic writing skills that students’ texts show at the beginning and at the end of their undergraduate education, and to investigate the paths chosen by students from different study backgrounds when they acquire competence in academic writing. The dissertation studies changes of level within the educational system from a student perspective. The empirical material consists of qualitative research interviews with student teachers at different stages of their training, and of the analyses of texts written by the same students. The study shows that both new and experienced students find it difficult to see a link between the tuition in Swedish in high school and their university studies, especially when it comes to academic writing. The new students therefore feel frustration and confusion in the transition phase. The experienced students say that they have mainly developed competence in academic writing during their studies through supervision in essay writing, which is felt to be crucial for linguistic development. The new students’ interim texts are characterized by the clear personal presence of an author, a varying degree of copying from source texts, and uncertain handling of references. Expressions of critical-analytical thinking are not common, and the texts usually have an everyday tone. The experienced students do not copy texts, yet they show great insecurity in their use of the content of the source texts. They write “academically” by using frequent reference markers and adopting a bombastic style. The linguistic tools of academic writing are used by the experienced students as decoration, to strengthen the impression of familiarity with the academic discourse.
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| 9. |
- Bill-Axelson, Anna, et al.
(författare)
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Radical prostatectomy versus watchful waiting in localized prostate cancer : the Scandinavian prostate cancer group-4 randomized trial
- 2008
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press. - 0027-8874 .- 1460-2105. ; 100:16, s. 1144-1154
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The benefit of radical prostatectomy in patients with early prostate cancer has been assessed in only one randomized trial. In 2005, we reported that radical prostatectomy improved prostate cancer survival compared with watchful waiting after a median of 8.2 years of follow-up. We now report results after 3 more years of follow-up.METHODS: From October 1, 1989, through February 28, 1999, 695 men with clinically localized prostate cancer were randomly assigned to radical prostatectomy (n = 347) or watchful waiting (n = 348). Follow-up was complete through December 31, 2006, with histopathologic review and blinded evaluation of causes of death. Relative risks (RRs) were estimated using the Cox proportional hazards model. Statistical tests were two-sided.RESULTS: During a median of 10.8 years of follow-up (range = 3 weeks to 17.2 years), 137 men in the surgery group and 156 in the watchful waiting group died (P = .09). For 47 of the 347 men (13.5%) who were randomly assigned to surgery and 68 of the 348 men (19.5%) who were not, death was due to prostate cancer. The difference in cumulative incidence of death due to prostate cancer remained stable after about 10 years of follow-up. At 12 years, 12.5% of the surgery group and 17.9% of the watchful waiting group had died of prostate cancer (difference = 5.4%, 95% confidence interval [CI] = 0.2 to 11.1%), for a relative risk of 0.65 (95% CI = 0.45 to 0.94; P = .03). The difference in cumulative incidence of distant metastases did not increase beyond 10 years of follow-up. At 12 years, 19.3% of men in the surgery group and 26% of men in the watchful waiting group had been diagnosed with distant metastases (difference = 6.7%, 95% CI = 0.2 to 13.2%), for a relative risk of 0.65 (95% CI = 0.47 to 0.88; P = .006). Among men who underwent radical prostatectomy, those with extracapsular tumor growth had 14 times the risk of prostate cancer death as those without it (RR = 14.2, 95% CI = 3.3 to 61.8; P < .001).CONCLUSION: Radical prostatectomy reduces prostate cancer mortality and risk of metastases with little or no further increase in benefit 10 or more years after surgery.
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| 10. |
- Byrman, Gunilla, 1953-, et al.
(författare)
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Språket på spåret mellan Lund och Växjö
- 2019
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Ingår i: HumaNetten. - Växjö : Linnaeus University Press. - 1403-2279. ; :43, s. 167-180
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- En tågresa är inte bara en förflyttning mellan olika orter. Den är också en resa i ett språkligt landskap, där det finns möjligheter att iaktta och begrunda olika språkligheter. Syftet med den här studien är att uppmärksamma några språkliga yttringar som vi iakttagit på pendlingsresor mellan Lund och Växjö. Forskningsfrågan är: Hur ser det språk ut som resenärerna möter på tåg och perronger? Materialet består av autentiska språkyttringar samlade på tågresor i Skåne och Småland, såsom högtalarutrop, dialekt och slang hos medpassagerare samt skriftliga anslag och meddelanden placerade ombord i tågen. Teoriram är kritisk diskursanalys kombinerad med språksociologi. Metod är närstudier och närläsning av språkproven. Resultaten visar uppseendeväckande variation i tågspråket på denna 185 kilometer långa tågresa.
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