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1.	Klein, F, et al. (author) Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants 2014 In: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 211:12, s. 2361-2372 Journal article (peer-reviewed)abstract Antibody-mediated immunotherapy is effective in humanized mice when combinations of broadly neutralizing antibodies (bNAbs) are used that target nonoverlapping sites on the human immunodeficiency virus type 1 (HIV-1) envelope. In contrast, single bNAbs can control simian–human immunodeficiency virus (SHIV) infection in immune-competent macaques, suggesting that the host immune response might also contribute to the control of viremia. Here, we investigate how the autologous antibody response in intact hosts can contribute to the success of immunotherapy. We find that frequently arising antibodies that normally fail to control HIV-1 infection can synergize with passively administered bNAbs by preventing the emergence of bNAb viral escape variants.
2.	Muir, D., et al. (author) Results of the SETAC workshop on science-based guidance for the evaluation and identification of PBTs and POPs 2008 Conference paper (peer-reviewed)

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Type of publication: conference paper (1); journal article (1)

Type of content: peer-reviewed (2)

Author/Editor: Liu, C. (1); Williams, C. (1); Nishimura, Y. (1); Hedestam, GBK (1); Jones, K (1); McLachlan, Michael (1); show more...; Klein, F. (1); Snape, J (1); Bridges, J (1); Phad, G (1); Fatkenheuer, G (1); Lehmann, C (1); Solomon, K. R. (1); Nichols, J. (1); Nussenzweig, MC (1); Scheringer, M. (1); Nogueira, L (1); Woodburn, K. (1); Bjorkman, PJ (1); Muir, D. (1); Zolla-Pazner, S (1); Seaman, MS (1); de Wolf, W. (1); Dohmen, P (1); Martin, MA (1); Escher, B. (1); West, AP (1); Halper-Stromberg, A (1); Horwitz, JA (1); Gazumyan, A (1); Eisenreich, TR (1); Shingai, M (1); Cowan-Ellsberry, C. (1); Klecka, G. (1); Boethling, R. (1); Weisbrod, A. V. (1); Gobas, F. (1); Holoubek, I. (1); Swackhamer, D. (1); van Wijk, D. (1); Chenier, R. (1); Eisenreich, S. (1); Tarazona, J. (1); show less...

University: Stockholm University (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Natural sciences (1)

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