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- Graf, W, et al.
(författare)
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Delorme's operation for rectal prolapse in elderly or unfit patients.
- 1992
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Ingår i: European Journal of Surgery. - 1102-4151 .- 1741-9271. ; 158:10, s. 555-7
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To evaluate the results after Delorme's operation for rectal prolapse in elderly and unfit patients.DESIGN: Retrospective analysis and telephone interview.SETTING: Akademiska sjukhuset, Uppsala, Sweden.SUBJECTS: A consecutive series of 14 women (median age 82, range 32-92) operated on for rectal prolapse 1987-1992 and followed up after a median of 18 months.RESULTS: There were no serious postoperative complications. Continence was improved in 6/11 incontinent patients. The recurrence rate was 3/14 (21%).CONCLUSION: Delorme's operation is an attractive alternative in elderly or unfit patients, but is not recommended for younger and low risk patients because of the recurrence rate.
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- Kressner, U, et al.
(författare)
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Intraoperative colonic lavage and primary anastomosis--an alternative to Hartmann procedure in emergency surgery of the left colon.
- 1994
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Ingår i: European Journal of Surgery. - 1102-4151 .- 1741-9271. ; 160:5, s. 287-92
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To assess whether intraoperative lavage and primary resection with anastomosis is a safe alternative to a Hartmann procedure in emergency surgery of the left colon.DESIGN: Retrospective study.SETTING: University hospital.MATERIAL: 101 consecutive patients (39 emergency and 62 elective) who underwent a left-sided colonic resection during a 3-year-period.INTERVENTIONS: 17 of the emergency procedures comprised an intraoperative lavage followed by resection and primary anastomosis without faecal diversion; 17 were Hartmann procedures and 5 patients had primary resection without lavage.MAIN OUTCOME MEASURES: Postoperative mortality, morbidity and duration of hospital stay in these two groups compared with these after a contemporary series of elective resections.RESULTS: There were no postoperative deaths and no clinical anastomotic leaks in the lavage group. The duration of hospital stay (median 11 days) was similar in both groups (overall and sigmoid resection respectively). In the Hartmann group, there were two deaths and the postoperative stay in hospital was significantly longer.CONCLUSIONS: Primary resection with intraoperative lavage can be done successfully in patients with acute obstruction of the left colon and the duration of hospital stay and morbidity are similar to those seen in patients operated on electively.
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- Nygård, G, et al.
(författare)
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Viability, prostaglandin E2 production, and protein handling in normal and inflamed human colonic mucosa cultured for up to 48 h in vitro.
- 1992
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Ingår i: Scandinavian Journal of Gastroenterology. - 0036-5521 .- 1502-7708. ; 27:4, s. 303-10
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Tidskriftsartikel (refereegranskat)abstract
- Human colonic mucosa obtained from colon cancer resections ('normal') and from colectomies owing to ulcerative colitis (inflamed) were cultured for up to 48 h in vitro. The 3H-leucine incorporation in normal tissue decreased to 52% (p less than 0.001) at 48 h compared with 24 h. The protein synthesis in normal but not in inflamed explants was significantly (p less than 0.01) improved at 48 h, reaching 72% of the 24-h value, on additions of insulin and the protease inhibitors aprotinin, soyabean trypsin inhibitor, and N alpha-tosyl-L-lysine chloromethyl ketone to the culture medium. Inflamed tissue had significant protein losses of 15% after 24 h and 29% after 48 h in culture, and the excretion of precipitable 3H-leucine-labelled proteins could be as high as 20%/24 h. A slight protein loss was observed in normal tissue after 48 h in culture, but the excretion of labelled proteins was very low (3%). The prostaglandin E2 (PGE2) production in both normal and inflamed tissue displayed an increasing non-linear pattern with time in culture, with higher values for inflamed tissue. The PGE2 release profiles and the differences in basic protein metabolism between normal and inflamed human colonic biopsy specimens in culture might reflect important characteristics of the inflammatory process.
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