1. |
- Nilsson, Bo, et al.
(författare)
-
C3 and C4 are strongly related to adipose tissue variables and cardiovascular risk factors
- 2014
-
Ingår i: European Journal of Clinical Investigation. - : John Wiley & Sons. - 0014-2972 .- 1365-2362. ; 44:6, s. 587-596
-
Tidskriftsartikel (refereegranskat)abstract
- Background In several reports, C3 and C4 have been linked to diabetes and cardiovascular disease (CVD). Here, we investigate this link and the degree of C3 activation in elderly individuals. Methods In this study, C3 and C4 and the activation fragment C3a-desArg were analysed in 1016 subjects aged 70, in which blood pressure, lipid variables and fasting blood glucose were assessed. Results C3 levels were related to all the investigated classical cardiovascular risk factors and the metabolic syndrome (BMI, waist circumference, fat distribution, blood pressure, blood glucose levels, TG) except total cholesterol and LDL cholesterol in a highly significant fashion (Spearman up to 0,5; P<0.0001). C4 and C3a-desArg were associated in the same fashion but less significantly, while the ratios C4/C3 or C3a-desArg/C3 were not, indicating thatthe association was not directly related to complement activation. The levels C3 and to a lesser degree C4 and C3a-desArg were associated particularly with CRP, but also with E-selectin and ICAM-1. In addition, C3 and C4 levels were shown to decline significantly in 15 female subjects enrolled in a weight-reduction programme over 4 months. Conclusion A strong relation between C3, C4 and C3a-desArg levels, adipose tissue and risk factors of CVD was established. The data support that theadipose tissue produces complement components and generates initiators of inflammation, such as C3a and C5a, able to trigger a cyto/chemokine response, in proportion to the amount of adipose tissue. This corroborates the concept that complement contributes to the low-grade inflammation associated with obesity.
|
|
2. |
|
|
3. |
- Berggren, Lars, et al.
(författare)
-
En arbetarhistoriker i ständig rörelse
- 2021
-
Ingår i: Från arbetets horisont : Perspektiv på historisk forskning om arbete och samhälle under kapitalismen - Perspektiv på historisk forskning om arbete och samhälle under kapitalismen. - 9789179243548 ; , s. 199-241
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
4. |
|
|
5. |
-
Då var det 1917
- 2017
-
Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)
|
|
6. |
|
|
7. |
- Ilshammar, Lars, et al.
(författare)
-
Hövdingen bakom galler : Hjalmar Branting
- 2012
-
Ingår i: … faror för staten av svåraste slag : politiska fångar på Långholmen 1880-1950. - 9789170312519 ; , s. 42-53
-
Bokkapitel (populärvet., debatt m.m.)
|
|
8. |
- Ilshammar, Lars, et al.
(författare)
-
Poeten som smädade Hitler : Ture Nerman
- 2012
-
Ingår i: … faror för staten av svåraste slag : politiska fångar på Långholmen 1880-1950. - 9789170312519 ; , s. 194-203
-
Bokkapitel (populärvet., debatt m.m.)
|
|
9. |
- Ilshammar, Lars, et al.
(författare)
-
Åtalsraseriets första offer : August Palm
- 2012
-
Ingår i: … faror för staten av svåraste slag : politiska fångar på Långholmen 1880-1950. - 9789170312519 ; , s. 30-41
-
Bokkapitel (populärvet., debatt m.m.)
|
|
10. |
|
|