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- Ahlmanner, Filip, et al.
(författare)
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CD39+ regulatory T cells accumulate in colon adenocarcinomas and display markers of increased suppressive function
- 2018
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Ingår i: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 9:97, s. 36993-37007
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Tidskriftsartikel (refereegranskat)abstract
- Increasing knowledge of the function and regulation of tumor-infiltrating lymphocytes has led to new insights in cancer immunotherapy. Regulatory T cells (Treg) accumulate in colon tumors, and we recently showed that CD39+ Treg from cancer patients inhibit transendothelial migration of conventional T cells. CD39 mediates the hydrolysis of ATP to immunosuppressive adenosine and adds to the immunosuppressive effects of Treg. Here, we further investigated the regulatory features of intratumoral CD39+ Treg in colon cancer. Using flow cytometry analyses of cells from 46 colon cancer patients, we confirm the accumulation of CD39+ Treg in the tumor tissue compared to unaffected colon tissue, and also show that tumor-infiltrating Treg express more CD39 and Foxp3 on a per cell basis. Furthermore, CD39+ Treg in tumors express markers indicating increased turnover and suppressive ability. In particular, tumor-infiltrating CD39+ Treg have high expression of surface molecules related to immunosuppression, such as ICOS, PD-L1 and CTLA-4. Functional suppression assays also indicate potent suppressive capacity of CD39+ Treg on proliferation and IFN-γ secretion by conventional T cells. In conclusion, our results identify tumor-infiltrating CD39+ Treg as a numerous and potentially important immunosuppressive subset, and suggest that immunotherapy aimed at reducing the activity of CD39+ Treg may be particularly useful in the setting of colon cancer. © 2018 Ahlmanner et al.
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| 3. |
- Backman, Fredrick, 1969-
(författare)
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Making Place for Space : a History of 'Space Town' Kiruna 1943-2000
- 2015
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Science and technology have a tendency to clump together in places where they spawn other forms of societal activities. Sometimes these places become famous through processes known as place-making, or the social construction of place. Because the scientific and technological activities affect the places, and the places conversely affect the science and technology, it is relevant to study how and why these connections emerge.This dissertation examines the particular case of the northern Swedish town of Kiruna, which has become known for being a `space town' because of its scientific, technological, and other activities that relate to the near space around the earth. The overall objective is to analyse the processes underlying the making of Kiruna as a space town in the period 1943--2000.Five parts make up the study. First is an examination of how the development of space physics research in Kiruna led to the setting up of a scientific observatory. The second part studies how the Swedish participation in the European Space Research Organisationmade Kiruna the place for a rocket base. Next follows an analysis of how local business efforts contributed to forming a new satellite technology business and the Space House office building. The fourth part concerns how the visions to establish a space `university' eventually led to the emergence of the Space Campus. Last is an epilogue that briefly analyses the space tourism efforts in Kiruna.A central finding is that the space town has emerged as the result of entwined processes where, on the one hand, ideas about the near space around the earth have led to new activities and physical structures, and, on the other hand, these new activities and built structures conversely have inspired to new ideas. Of importance is also the geographical place where these developments have occurred. Here, a reoccurring argument to placing the activities and structures in Kiruna was the town's geographically favourable location for specific scientific and technological activities.Another finding is that the development has gradually led to the emergence of a kind of identity or notion of Kiruna as a particular place for space activities. Although this form of place-making has occurred largely through spontaneous processes, it was also the result of intentional efforts.Together, these different place-making processes have formed the `space town' of Kiruna.
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| 4. |
- Egan Sjölander, Annika, et al.
(författare)
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Fuel of the Future? The BioFuel Region case.
- 2008
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Ingår i: Paper presented at the conference Teknik-och Vetenskapshistoriska dagar, Stockholm, April 2008..
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Konferensbidrag (refereegranskat)
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| 5. |
- Egan Sjölander, Annika, 1971-, et al.
(författare)
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Motorspriten kommer! : en historia om etanol och andra alternativa drivmedel
- 2014
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Motorspriten kommer! löd budskapet i början av 1900-talet. Liknande utfästelser om alternativa drivmedel har gång på gång hörts genom historien. Men de oljebaserade bränslena har behållit sitt grepp om transportsystemet, trots att de alltid ansetts problematiska. Varför?Den här boken handlar om olika försök att utveckla och förverkliga alternativ till oljebaserade drivmedel i Sverige. Den spänner över ett drygt sekel, från slutet av 1800-talet och framåt, och behandlar bland annat sulfitsprit, syntetisk bensin, gengas, metanol och den första och andra generationens etanol. I fokus står motiven bakom dessa alternativ varför de har ansetts angelägna och önskvärda liksom de problem och strukturella hinder som de har mött och alltjämt fortsätter att möta. Boken ger historiska och medievetenskapliga perspektiv på de pågående försöken till en omställning på drivmedelsområdet och bidrar till kunskap av värde för såväl beslutsfattare som allmänhet.Boken bygger på forskning som utfördes inom det tvärvetenskapliga projektet Framtidens drivmedel? Biobränslen i historisk och kulturell belysning. Den är skriven av samtliga forskare i projektet Annika Egan Sjölander, Helena Ekerholm, Jenny Eklöf, Erland Mårald, Christer Nordlund och Bosse Sundin i samarbete med Henrik Lång.
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| 10. |
- Eklöf, Jenny, 1973-, et al.
(författare)
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En humanistisk fågel Fenix : från kris till offensiv
- 2013
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Ingår i: Kulturella perspektiv - Svensk etnologisk tidskrift. - Umeå : Föreningen Kulturella Perspektiv vid Umeå universitet. - 1102-7908. ; :1, s. 49-51
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Tidskriftsartikel (refereegranskat)
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