| 1. |
|
|
| 2. |
- Burlaka, Ievgeniia, et al.
(författare)
-
Prevention of apoptosis averts glomerular tubular disconnection and podocyte loss in proteinuric kidney disease
- 2016
-
Ingår i: Kidney International. - : Nature Publishing Group. - 0085-2538 .- 1523-1755. ; 90:1, s. 135-148
-
Tidskriftsartikel (refereegranskat)abstract
- There is a great need for treatment that arrests progression of chronic kidney disease. Increased albumin in urine leads to apoptosis and fibrosis of podocytes and tubular cells and is a major cause of functional deterioration. There have been many attempts to target fibrosis, but because of the lack of appropriate agents, few have targeted apoptosis. Our group has described an ouabain-activated Na,K-ATPase/IP3R signalosome, which protects from apoptosis. Here we show that albumin uptake in primary rat renal epithelial cells is accompanied by a time-and dose-dependent mitochondrial accumulation of the apoptotic factor Bax, down-regulation of the antiapoptotic factor Bcl-xL and mitochondrial membrane depolarization. Ouabain opposes these effects and protects from apoptosis in albumin-exposed proximal tubule cells and podocytes. The efficacy of ouabain as an antiapoptotic and kidney-protective therapeutic tool was then tested in rats with passive Heymann nephritis, a model of proteinuric chronic kidney disease. Chronic ouabain treatment preserved renal function, protected from renal cortical apoptosis, up-regulated Bax, down-regulated Bcl-xL, and rescued from glomerular tubular disconnection and podocyte loss. Thus we have identified a novel clinically feasible therapeutic tool, which has the potential to protect from apoptosis and rescue from loss of functional tissue in chronic proteinuric kidney disease.
|
|
| 3. |
|
|
| 4. |
- Eklöf, Linnéa, et al.
(författare)
-
Co-Exploring Everyday Life of Adults with ADHD
- 2013
-
Ingår i: Assistive Technology Research Series. ; 33:Assistive Technology: From Research to Practice, s. 622-627
-
Konferensbidrag (refereegranskat)abstract
- There are relatively few studies based on an individual adult perspective on ADHD which takes into account how various factors interact and affect everyday life. Compensatory strategies can facilitate life for people with ADHD and those strategies might include the use of assistive technology or cognitive support. The purpose of this paper is to present and discuss how various factors can facilitate or challenge a person's tendency to adopt technology to better meet the demands and expectations of adult life. Participant observations and narrative interviews were used while co-exploring the life of three adults diagnosed with ADHD. By using this method the participants' own solutions, adaptions and preferences regarding cognitive support and assistive technology become visible. Results showed that factors like negative symptoms, stress, sleep deprivation, financial- or social problems effected the participant's motivation, feelings of competence, ability to identify prioritized activities and to maintain supportive routines – things that have been proven to be important for assistive technology use. Developing useworthy support and technology that meets the needs of people with ADHD is important in order to enable autonomy and compensate for the impairment.
|
|
| 5. |
|
|
| 6. |
|
|
