| 1. |
- Ekman, Petter, 1988-, et al.
(författare)
-
Accuracy and Speed for Scale-Resolving Simulations of the DrivAer Reference Model
- 2019
-
Ingår i: WCX SAE World Congress Experience. - 400 Commonwealth Drive, Warrendale, PA, United States : SAE International.
-
Konferensbidrag (refereegranskat)abstract
- In aerodynamic development of ground vehicles, the use of Computational Fluid Dynamics (CFD) is crucial for improving the aerodynamic performance, stability and comfort of the vehicle. Simulation time and accuracy are two key factors of a well working CFD procedure. Using scale-resolving simulations, accurate predictions of the flow field and aerodynamic forces are possible, but often leads to long simulation time. For a given solver, one of the most significant aspects of the simulation time/cost is the temporal resolution. In this study, this aspect is investigated using the realistic vehicle model DrivAer with the notchback geometry as the test case. To ensure a direct and accurate comparison with wind tunnel measurements, performed at TU Berlin, a large section of the wind tunnel is included in the simulation domain. All simulations are performed at a Reynolds number of 3.12 million, based on the vehicle length. Three spatial resolutions were compared, where it could be seen that a hybrid element mesh consisting of 102 million cells only revealed small differences to the finest mesh investigated, well as showing excellent agreement with wind tunnel measurements. An investigation of the temporal resolution is performed, in order to see its effect on the simulation time/cost and accuracy of the results. The finest temporal resolution resulted in a Courant-Friedrichs-Lewy number less than unity, while the coarsest reached a CFL number of around 100. From these results, it is seen that it is possible to reduce the simulation time with more than 90 % (CFL 20) and still keep sufficient accuracy of the forces and important features of the flow field.
|
|
| 2. |
- Aad, G., et al.
(författare)
-
Observation of Single-Top-Quark Production in Association with a Photon Using the ATLAS Detector
- 2023
-
Ingår i: Physical Review Letters. - : American Physical Society (APS). - 0031-9007 .- 1079-7114. ; 131:18
-
Tidskriftsartikel (refereegranskat)abstract
- This Letter reports the observation of single top quarks produced together with a photon, which directly probes the electroweak coupling of the top quark. The analysis uses 139 fb−1 of 13 TeV proton-proton collision data collected with the ATLAS detector at the Large Hadron Collider. Requiring a photon with transverse momentum larger than 20 GeV and within the detector acceptance, the fiducial cross section is measured to be 688±23(stat) , to be compared with the standard model prediction of at next-to-leading order in QCD.
|
|
| 3. |
- Almqvist, Fredrik, et al.
(författare)
-
Synthesis of Optically Active endo, endo Bicyclo[2.2.2]octane-2,5- diol, Bicyclo[2.2.2]octan-2,5-dione and Related Compounds
- 1996
-
Ingår i: Journal of Organic Chemistry. - : American Chemical Society (ACS). - 1520-6904 .- 0022-3263. ; 61:11, s. 3794-3798
-
Tidskriftsartikel (refereegranskat)abstract
- Optically active C-2-symmetric (1S,2S,4S,5S)-bicyclo[2.2.2]octane-2,5-diol ((+)-12; 98% ee) and several selectivity protected optically active intermediates useful for synthetic transformations were synthesized via a 1,2-carbonyl transposition route starting from the easily available optically active (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octan-2-one ((-)-2). The synthetic route also allowed the preparation of optically active (1S,4S)-bicyclo[2.2.2]octane-2,5-dione ((+)-14; 98% ee).
|
|
| 4. |
- Asberg, Marie, et al.
(författare)
-
Novel biochemical markers of psychosocial stress in women.
- 2009
-
Ingår i: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 4:1
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Prolonged psychosocial stress is a condition assessed through self-reports. Here we aimed to identify biochemical markers for screening and early intervention in women. METHODS: Plasma concentrations of interleukin (IL) 1-alpha, IL1-beta, IL-2, IL-4, IL-6, IL-8, IL-10, interferon-gamma (INF-gamma), tumor necrosis factor-alpha (TNF-alpha), monocyte chemotactic protein-1 (MCP-1), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), thyroid stimulating hormone (TSH), total tri-iodothyronine (TT3), total thyroxine (TT4), prolactin, and testosterone were measured in: 195 women on long-term sick-leave for a stress-related affective disorder, 45 women at risk for professional burnout, and 84 healthy women. RESULTS: We found significantly increased levels of MCP-1, VEGF and EGF in women exposed to prolonged psychosocial stress. Statistical analysis indicates that they independently associate with a significant risk for being classified as ill. CONCLUSIONS: MCP-1, EGF, and VEGF are potential markers for screening and early intervention in women under prolonged psychosocial stress.
|
|
| 5. |
- Asklund, Ulf, et al.
(författare)
-
Configuration management for eXtreme programming
- 2003
-
Konferensbidrag (refereegranskat)abstract
- Extreme Programming (XP) is becoming popular as a software development method and there is quite a lot of literature describing its philosophy and practices. However, in all of this literature Software Configuration Management (SCM) is almost never mentioned explicitly, leaving XP practitioners with the impression that SCM is not needed and SCM people with the impression that XP is not sound from an SCM perspective. We carried out a more profound analysis of XP and its practices seen from an SCM perspective. We found that in general XP and its practices do not go against common SCM standards, if we take into consideration that the XP context is different from that of more traditional projects. However, some SCM aspects need to be made explicit and a number of SCM-specific sub-practices need to be added to make XP a complete and sound development method seen from an SCM perspective. We report on how we implemented “our findings” on several dozen XP projects and our experience from doing this through several iterations.
|
|
| 6. |
- Asklund, Ulf, et al.
(författare)
-
Software Configuration Management Practices for eXtreme Programming Teams
- 2004
-
Ingår i: Proceedings of the 11th Nordic Workshop on Programming and Software Development Tools and Techniques NWPER'2004. - 952121385X
-
Konferensbidrag (refereegranskat)abstract
- Extreme Programming (XP) is becoming popular as a software development method and there is quite a lot of literature describing its philosophy and practices. However, in all of this literature Software Configuration Management (SCM) is almost never mentioned explicitly, leaving XP practitioners with the impression that SCM is not needed and SCM people with the impression that XP is not sound from an SCM perspective. We carried out a more profound analysis of XP and its practices seen from an SCM perspective. We found that in general XP and its practices do not go against common SCM standards, if we take into consideration that the XP context is different from that of more traditional projects. However, some SCM aspects need to be made explicit and a number of SCM-specific sub-practices need to be added to make XP a complete and sound development method seen from an SCM perspective. We report on how we implemented “our findings” on several dozen XP projects and our experience from doing this through several iterations.
|
|
| 7. |
- Axelsson, John, et al.
(författare)
-
Effects of Sustained Sleep Restriction on Mitogen-Stimulated Cytokines, Chemokines and T Helper 1/T Helper 2 Balance in Humans
- 2013
-
Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 8:12
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Recent studies suggest that acute sleep deprivation disrupts cellular immune responses by shifting T helper (Th) cell activity towards a Th2 cytokine profile. Since little is known about more long-term effects, we investigated how five days of sleep restriction would affect pro-inflammatory, chemotactic, Th1- and Th2 cytokine secretion. Methods: Nine healthy males participated in an experimental sleep protocol with two baseline sleep-wake cycles (sleep 23.00 - 07.00 h) followed by 5 days with restricted sleep (03.00 - 07.00 h). On the second baseline day and on the fifth day with restricted sleep, samples were drawn every third hour for determination of cytokines/chemokines (tumor necrosis factor alpha (TNF-alpha), interleukin (IL) -1 beta, IL-2, IL-4 and monocyte chemoattractant protein-1 (MCP-1)) after in vitro stimulation of whole blood samples with the mitogen phytohemagglutinin (PHA). Also leukocyte numbers, mononuclear cells and cortisol were analysed. Results: 5-days of sleep restriction affected PHA-induced immune responses in several ways. There was a general decrease of IL-2 production (p<.05). A shift in Th1/Th2 cytokine balance was also evident, as determined by a decrease in IL2/IL4 ratio. No other main effects of restricted sleep were shown. Two significant interactions showed that restricted sleep resulted in increased TNF-alpha and MCP-1 in the late evening and early night hours (p's<.05). In addition, all variables varied across the 24 h day. Conclusions: 5-days of sleep restriction is characterized by a shift towards Th2 activity (i.e. lower 1L-2/IL-4 ratio) which is similar to the effects of acute sleep deprivation and psychological stress. This may have implications for people suffering from conditions characterized by excessive Th2 activity like in allergic disease, such as asthma, for whom restricted sleep could have negative consequences. BAS AK, 1991, IMMUNOLOGICAL REVIEWS, V123, P5
|
|
| 8. |
- Babajan, Tigran, 1986-
(författare)
-
Oligarchs, State Power and Mass Opinion : A Study of the Role of Oligarchs in Post-Soviet Pseudo-democracies
- 2018
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis attempts to understand the role of oligarchs in post-Soviet pseudo-democratic regime trajectories. The two dominant, competing streams of prior work have emphasized either the importance of state power or that of mass opinion in these processes in order to explain why some regimes successfully maintain their grip on power, while others make gradual steps towards democratization. However, the role of oligarchs has been largely overlooked; a gap filled by this study. It employs both widely accepted, as well as unique data to approach the research problem. The work presented in this thesis involves large-N surveys, analyses of media reports and an in-depth case study. There are three key findings:First, for an overwhelming majority of citizens in post-Soviet pseudo-democracies, oligarchs’ actual, negative influence on the political system as well as popular perceptions of unfair wealth concentration are conducive to beliefs that a non-democratic regime is what is needed in order to set things right in their country.Second, the findings from Armenia, Georgia, Russia and Ukraine demonstrate that four politically motivated, rival oligarchs focused on enhancing their reputation and organizational capacity in their struggles for power. In all four countries, regimes used their state power to counter the rival oligarchs. Evidence from Armenia and Russia provides a nuanced understanding of these interactions. In particular, incumbents in these countries used their state power to manipulate public opinion in order to damage the reputation and credibility of the rival oligarchs. This thesis suggests that the main regime leaders do so in order to portray themselves as more trustworthy than their oligarch rivals.Third, a survey analysis of Kyiv university students shows that they view most oligarchs as corrupt and harmful to their political system. According to the survey results, oligarchs’ concentration of wealth appears to disqualify them from being legitimate political players. Yet, further evidence from this thesis suggests that people differentiate between oligarchs as a group and as individuals, which allows at least some oligarchs to enhance their reputation by using their vast material wealth. I conclude this thesis by discussing possible policy and societal implication of the results and by setting out some new venues of future research.
|
|
| 9. |
- Bendix, Lars, et al.
(författare)
-
Software Configuration Management in Agile Development
- 2007
-
Ingår i: Agile Software Development Quality Assurance. - 9781599042169
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Software Configuration Management (SCM) is an essential part of any software project and its importance is even greater on Agile projects because of the frequency of changes. In this chapter, we argue that SCM needs to be done differently and also cover more aspects on Agile projects. We also explain how SCM processes and tools contribute both directly and indirectly to quality assurance. We give a brief introduction to central SCM principles and define a number of typical Agile activities. Subsequently, we show that there are general SCM guidelines for how to support and strengthen these typical Agile activities. Furthermore, we establish a set of requirements that an Agile method must satisfy to benefit the most from SCM. Following our general guidelines, an Agile project can adapt the SCM processes and tools to its specific Agile method and its particular context.
|
|
| 10. |
- Bergemalm, Daniel, 1977-, et al.
(författare)
-
Systemic Inflammation in Preclinical Ulcerative Colitis
- 2021
-
Ingår i: Gastroenterology. - : AGA Institute. - 0016-5085 .- 1528-0012. ; 161:5, s. 1526-1539.e9
-
Tidskriftsartikel (refereegranskat)abstract
- Background & Aims: Preclinical ulcerative colitis is poorly defined. We aimed to characterize the preclinical systemic inflammation in ulcerative colitis, using a comprehensive set of proteins.Methods: We obtained plasma samples biobanked from individuals who developed ulcerative colitis later in life (n = 72) and matched healthy controls (n = 140) within a population-based screening cohort. We measured 92 proteins related to inflammation using a proximity extension assay. The biologic relevance of these findings was validated in an inception cohort of patients with ulcerative colitis (n = 101) and healthy controls (n = 50). To examine the influence of genetic and environmental factors on these markers, a cohort of healthy twin siblings of patients with ulcerative colitis (n = 41) and matched healthy controls (n = 37) were explored.Results: Six proteins (MMP10, CXCL9, CCL11, SLAMF1, CXCL11 and MCP-1) were up-regulated (P < .05) in preclinical ulcerative colitis compared with controls based on both univariate and multivariable models. Ingenuity Pathway Analyses identified several potential key regulators, including interleukin-1β, tumor necrosis factor, interferon-gamma, oncostatin M, nuclear factor-κB, interleukin-6, and interleukin-4. For validation, we built a multivariable model to predict disease in the inception cohort. The model discriminated treatment-naïve patients with ulcerative colitis from controls with leave-one-out cross-validation (area under the curve = 0.92). Consistently, MMP10, CXCL9, CXCL11, and MCP-1, but not CCL11 and SLAMF1, were significantly up-regulated among the healthy twin siblings, even though their relative abundances seemed higher in incident ulcerative colitis.Conclusions: A set of inflammatory proteins are up-regulated several years before a diagnosis of ulcerative colitis. These proteins were highly predictive of an ulcerative colitis diagnosis, and some seemed to be up-regulated already at exposure to genetic and environmental risk factors.
|
|
