| 1. |
- de Jong, S, et al.
(författare)
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Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
- 2018
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Ingår i: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 1, s. 163-
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Tidskriftsartikel (refereegranskat)abstract
- Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.
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| 2. |
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| 3. |
- Aurand, Bastian, et al.
(författare)
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Enhanced radiation pressure-assisted acceleration by temporally tuned counter-propagating pulses
- 2014
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Ingår i: Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment. - : Elsevier BV. - 0167-5087 .- 0168-9002. ; 740, s. 83-86
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Tidskriftsartikel (refereegranskat)abstract
- Within the last decade, laser-ion acceleration has become a field of broad interest. The possibility to generate short proton- or heavy ion bunches with an energy of a few tens of MeV by table-top laser systems could open new opportunities for medical or technical applications. Nevertheless, today's laser-acceleration schemes lead mainly to a temperature-like energy distribution of the accelerated ions, a big disadvantage compared to mono-energetic beams from conventional accelerators. Recent results 111 of laser-ion acceleration using radiation-pressure appear promising to overcome this drawback. In this paper, we demonstrate the influence of a second counter-propagating laser pulse interacting with a nm-thick target, creating a well defined pre-plasma. (C) 2013 Elsevier B.V. All rights reserved.
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| 4. |
- Aurand, Bastian, et al.
(författare)
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Radiation pressure-assisted acceleration of ions using multi-component foils in high-intensity laser-matter interactions
- 2013
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Ingår i: New Journal of Physics. - : IOP Publishing. - 1367-2630. ; 15
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Tidskriftsartikel (refereegranskat)abstract
- Experimental results on the acceleration of protons and carbon ions from ultra-thin polymer foils at intensities of up to 6x10(19)Wcm(-2) are presented revealing quasi-monoenergetic spectral characteristics for different ion species at the same time. For carbon ions and protons, a linear correlation between the cutoff energy and the peak energy is observed when the laser intensity is increased. Particle-in-cell simulations supporting the experimental results imply an ion acceleration mechanism driven by the radiation pressure as predicted for multi-component foils at these intensities.
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| 5. |
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| 6. |
- Carlsson, Sigrid, 1982, et al.
(författare)
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Risk of Incisional Hernia after Minimally Invasive and Open Radical Prostatectomy
- 2013
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Ingår i: The Journal of urology. - : Ovid Technologies (Wolters Kluwer Health). - 1527-3792 .- 0022-5347. ; 190:5, s. 1757-1762
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE:: The number of radical prostatectomies has increased. Many urologists have shifted from the open surgical approach to minimally invasive techniques. It is not clear whether the risk of post-prostatectomy incisional hernia varies by surgical approach. MATERIALS AND METHODS:: In the linked Surveillance, Epidemiology, and End Results (SEER)-Medicare dataset we identified men age 66 and older who had minimally invasive (MIRP) or open radical prostatectomy (ORP) for prostate cancer diagnosed 2003-2007. The main outcome was incisional hernia repair identified in Medicare claims following prostatectomy. We also examined the frequency of umbilical, inguinal and other hernia repairs. RESULTS:: We identified 3,199 patients who had MIRP and 6,795 who had open radical prostatectomy ORP. The frequency of incisional hernia repair was 5.3% (median follow-up 3.1 years) in the MIRP group and 1.9% (median follow-up 4.4 years) in the ORP group, corresponding to incidence rates of 16.1 and 4.5 per 1000 person-years for MIRP and ORP, respectively. Compared with ORP, MIRP was associated with a more than 3-fold increased risk of incisional hernia repair, controlling for patient and disease characteristics (adjusted hazard ratio 3.39, 95% CI, 2.63-4.38, p <0.0001). MIRP was associated with an attenuated but increased risk of any hernia repair compared with ORP (adjusted hazard ratio 1.48, 95% CI 1.29-1.70, p <0.0001), driven by incisional hernias. CONCLUSIONS:: MIRP was associated with a significantly increased risk of incisional hernia compared with ORP. This is a potentially remediable complication of prostate cancer surgery that warrants increased vigilance with respect to surgical technique.
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| 7. |
- Elkin, Michael, et al.
(författare)
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Energy Fluctuations Shape Free Energy of Nonspecific Biomolecular Interactions
- 2012
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Ingår i: Journal of Statistical Physics. - : Springer Science and Business Media LLC. - 1572-9613 .- 0022-4715. ; 146:4, s. 870-877
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Tidskriftsartikel (refereegranskat)abstract
- Understanding design principles of biomolecular recognition is a key question of molecular biology. Yet the enormous complexity and diversity of biological molecules hamper the efforts to gain a predictive ability for the free energy of protein-protein, protein-DNA, and protein-RNA binding. Here, using a variant of the Derrida model, we predict that for a large class of biomolecular interactions, it is possible to accurately estimate the relative free energy of binding based on the fluctuation properties of their energy spectra, even if a finite number of the energy levels is known. We show that the free energy of the system possessing a wider binding energy spectrum is almost surely lower compared with the system possessing a narrower energy spectrum. Our predictions imply that low-affinity binding scores, usually wasted in protein-protein and protein-DNA docking algorithms, can be efficiently utilized to compute the free energy. Using the results of Rosetta docking simulations of protein-protein interactions from Andre et al. (Proc. Natl. Acad. Sci. USA 105: 16148, 2008), we demonstrate the power of our predictions.
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| 8. |
- Garsen, Marjolein, et al.
(författare)
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Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis
- 2016
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Ingår i: American Journal of Pathology. - : Elsevier BV. - 0002-9440 .- 1525-2191. ; 186:4, s. 805-815
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Tidskriftsartikel (refereegranskat)abstract
- Heparanase, a heparan sulfate (HS)-specific endoglucuronidase, mediates the onset of proteinuria and renal damage during experimental diabetic nephropathy. Glomerular heparanase expression is increased in most proteinuric diseases. Herein, we evaluated the role of heparanase in two models of experimental glomerulonephritis, being anti-glomerular basement membrane and lipopolysaccharide-induced glomerulonephritis, in wild-type and heparanase-deficient mice. Induction of experimental glomerulonephritis Led to an increased heparanase expression in wild-type mice, which was associated with a decreased glomerular expression of a highly sulfated HS domain, and albuminuria. Albuminuria was reduced in the heparanase-deficient mice in both models of experimental glomerulonephritis, which was accompanied by a better renal function and less renal damage. Notably, glomerular HS expression was preserved in the heparanase-deficient mice. Glomerular leukocyte and macrophage influx was reduced in the heparanase-deficient mice, which was accompanied by a reduced expression of both types 1 and 2 helper T-cell cytokines. In vitro, tumor necrosis factor-alpha and Lipopolysaccharide directly induced heparanase expression and increased transendothelial albumin passage. Our study shows that heparanase contributes to proteinuria and renal damage in experimental glomerulonephritis by decreasing glomerular HS expression, enhancing renal leukocyte and macrophage influx, and affecting the Local cytokine milieu.
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| 9. |
- Vieira, Thomas, et al.
(författare)
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Development of an axial flux machine and control : simulation and experimental set up
- 2016
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Ingår i: 2016 12th IEEE/IAS International Conference On Industry Applications (INDUSCON). - 9781509051274
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Konferensbidrag (refereegranskat)abstract
- Simulation and experimental development of a driving system and control for an axial flux permanent magnet machine has been developed. The complete system, including the machine design and construction, has been accomplished due to the collaboration among different universities in Brazil and Sweden. Final experimental setup is aimed for testing a passive levitation system, which can be used as small flywheel energy storage. Simulations have been implemented using Simulink. The design and construction of different components of the driving system are presented, in a way so they can be reproduced. Control strategy has been implemented using Labview and Compact-Rio. Results show the functionality of the complete system at a nominal speed of 2800 rpm.
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