| 1. |
|
|
| 2. |
- Gobel, K., et al.
(författare)
-
Measurement of the Mo-92,Mo-93,Mo-94,Mo-100(gamma,n) reactions by Coulomb Dissociation
- 2016
-
Ingår i: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 665:1, s. art. no. 012034-
-
Konferensbidrag (refereegranskat)abstract
- The Coulomb Dissociation (CD) cross sections of the stable isotopes Mo-92,Mo-94,Mo-100 and of the unstable isotope Mo-93 were measured at the LAND/(RB)-B-3 setup at GSI Helmholtzzentrum fur Schwerionenforschung in Darmstadt, Germany. Experimental data on these isotopes may help to explain the problem of the underproduction of Mo-92,Mo-94 and Ru-96,Ru-98 in the models of p-process nucleosynthesis. The CD cross sections obtained for the stable Mo isotopes are in good agreement with experiments performed with real photons, thus validating the method of Coulomb Dissociation. The result for the reaction Mo-93(gamma,n) is especially important since the corresponding cross section has not been measured before. A preliminary integral Coulomb Dissociation cross section of the Mo-94(gamma,n) reaction is presented. Further analysis will complete the experimental database for the (gamma,n) production chain of the p-isotopes of molybdenum.
|
|
| 3. |
- Köpper, Frederik, et al.
(författare)
-
Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity
- 2013
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 110:42, s. 16856-16861
-
Tidskriftsartikel (refereegranskat)abstract
- DNA damage can obstruct replication forks, resulting in replicative stress. By siRNA screening, we identified kinases involved in the accumulation of phosphohistone 2AX (gamma H2AX) upon UV irradiation-induced replication stress. Surprisingly, the strongest reduction of phosphohistone 2AX followed knockdown of the MAP kinase-activated protein kinase 2 (MK2), a kinase currently implicated in p38 stress signaling and G2 arrest. Depletion or inhibition of MK2 also protected cells from DNA damage-induced cell death, and mice deficient for MK2 displayed decreased apoptosis in the skin upon UV irradiation. Moreover, MK2 activity was required for damage response, accumulation of ssDNA, and decreased survival when cells were treated with the nucleoside analogue gemcitabine or when the checkpoint kinase Chk1 was antagonized. By using DNA fiber assays, we found that MK2 inhibition or knockdown rescued DNA replication impaired by gemcitabine or by Chk1 inhibition. This rescue strictly depended on transiesion DNA polymerases. In conclusion, instead of being an unavoidable consequence of DNA damage, alterations of replication speed and origin firing depend on MK2-mediated signaling.
|
|
| 4. |
- Mahata, K., et al.
(författare)
-
Study of dipole excitations and the single particle structure of neutron rich Ni isotopes
- 2008
-
Ingår i: AIP Conference Proceedings. - 1551-7616 .- 0094-243X. ; 1012, s. 389-391 453
-
Konferensbidrag (refereegranskat)abstract
- An experiment was performed using the FRS-LAND setup at GSI to study the dipole strength distributions above neutron separation threshold for neutron-rich Ni isotopes. Measurements, using the same experimental setup, were also carried out to extract single particle occupancies via knockout reactions to investigate the structure and magicity of the neutron-rich Ni isotopes. The status of the data analysis and preliminary results are presented.
|
|
| 5. |
- McCutchan, E.A., et al.
(författare)
-
Precise γ-ray intensity measurements in 10B
- 2012
-
Ingår i: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993. ; 86:5
-
Tidskriftsartikel (refereegranskat)abstract
- Precise electromagnetic transition matrix elements in 10Be and 10C have provided surprisingly stringent tests of modern ab initio calculations using realistic nuclear forces. The analog transition in 10B can further constrain these new calculations and probe the symmetry of the wave functions across the A=10 multiplet. We report on a careful measurement of the γ-ray intensities from states populated in the 10B(p,p) reaction at 10 MeV, including a determination of the key E2 branch from the J=2 T=1 state at 5164keV to the J=0 T=1 state at 1740keV of 0.16(4)%. © 2012 American Physical Society.
|
|
| 6. |
- Oostendorp, R. A. B., et al.
(författare)
-
Clinical Characteristics and Patient-Reported Outcomes of Primary Care Physiotherapy in Patients with Whiplash-Associated Disorders: A Longitudinal Observational Study
- 2020
-
Ingår i: Patient Preference and Adherence. - 1177-889X. ; 14, s. 1733-1750
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Whiplash-associated disorders (WADS) constitute a state of health characterized by a wide diversity of symptoms as a result of impairments of functions, activity limitations, and participation restrictions. Patient-reported outcome measurements (PROMs) and patient-reported outcomes (PROs) seem appropriate when describing and evaluating the health status of patients with WAD. Aim: To measure the use of PROMs and PROs as quality indicators in clinical reasoning, and to analyze and evaluate pre- and post-treatment 'pain intensity' and 'functioning', and for 'perceived improvement' in patients with WAD in primary care physiotherapy practice by year of referral, with the phase after accident and prognostic health profile embedded in the clinical reasoning process. Materials and Methods: Data were collected over a period of 10 years. Pain intensity, functioning, and perceived improvement were measured using the Visual Analogue Scale for Pain (VAS-P), the Neck Disability Index (NDI) and the Global Perceived Effect scale (GPE). Pre- and post-treatment mean differences were tested for statistical significance and compared to minimal clinically important differences (MCID). Effect sizes were expressed as Cohen's d. Multivariable regression analysis was performed to explore independent associations of year of referral, phase after the accident, and the patient's prognostic health profile with post-treatment pain intensity and functioning. Results: A consecutive sample of 523 patients was included. Pre- and post-treatment mean differences on VAS-P and NDI were statistically significant (P<0.000) and clinically relevant, with `large' effect sizes for pain intensity and functioning. MCIDs were achieved by 80% for VAS-P and for 60% for NDI. Year of referral and phase after the accident were independently associated with worse post-treatment functioning. About half of the patients (n=241 [46.1%1) perceived themselves as improved. Conclusion: The PROMs and PROs pain intensity, functioning and perceived improvement were integrated as quality indicators in the physiotherapy clinical reasoning process for patients with WAD. Significant differences in pain intensity and functioning were found but were unrelated to year of referral, phase after whiplash-related injury or prognostic health profile. The MCID VAS-P scores did not differ depending on experienced pain.
|
|
| 7. |
- Vieira, Natassia M., et al.
(författare)
-
Jagged 1 Rescues the Duchenne Muscular Dystrophy Phenotype
- 2015
-
Ingår i: Cell. - : Elsevier BV. - 0092-8674 .- 1097-4172. ; 163:5, s. 1204-1213
-
Tidskriftsartikel (refereegranskat)abstract
- Duchenne muscular dystrophy (DMD), caused by mutations at the dystrophin gene, is the most common form of muscular dystrophy. There is no cure for DMD and current therapeutic approaches to restore dystrophin expression are only partially effective. The absence of dystrophin in muscle results in dysregulation of signaling pathways, which could be targets for disease therapy and drug discovery. Previously, we identified two exceptional Golden Retriever muscular dystrophy (GRMD) dogs that are mildly affected, have functional muscle, and normal lifespan despite the complete absence of dystrophin. Now, our data on linkage, whole-genome sequencing, and transcriptome analyses of these dogs compared to severely affected GRMD and control animals reveals that increased expression of Jagged1 gene, a known regulator of the Notch signaling pathway, is a hallmark of the mild phenotype. Functional analyses demonstrate that Jagged1 overexpression ameliorates the dystrophic phenotype, suggesting that Jagged1 may represent a target for DMD therapy in a dystrophin-independent manner.
|
|
| 8. |
- Werner, V., et al.
(författare)
-
Evolution of collectivity near mid-shell from excited-state lifetime measurements in rare earth nuclei
- 2016
-
Ingår i: Physical Review C. - 2469-9985 .- 2469-9993. ; 93:3
-
Tidskriftsartikel (refereegranskat)abstract
- The B(E2) excitation strength of the first excited 2(+) state in even-even nuclei should directly correlate with the size of the valence space and maximize at mid-shell. A previously found saturation of B(E2) strengths in well-deformed rotors at mid-shell is tested through high-precision measurements of the lifetimes of the lowest-lying 2(+) states of the Hf-168 and W-174 rare earth isotopes. Measurements were performed using fast LaBr3 scintillation detectors. Combined with the recently remeasured B(E2; 2(1)(+) -> 0(1)(+)) values for Hf and W isotopes the new data remove discrepancies observed in the differentials of B(E2) values for these isotopes.
|
|
