| 1. |
- Abelsson, Johanna, et al.
(författare)
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Patients with polycythemia vera have worst impairment of quality of life among patients with newly diagnosed myeloproliferative neoplasms
- 2013
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Ingår i: Leukemia and Lymphoma. - : Informa UK Limited. - 1042-8194 .- 1029-2403. ; 54:10, s. 2226-2230
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Tidskriftsartikel (refereegranskat)abstract
- The quality of life (QoL) at the time of diagnosis of myeloproliferative neoplasm (MPN) has, to date, not been studied. One hundred and seventy-nine patients with MPN: 80 with essential thrombocythemia (ET), 73 with polycythemia vera (PV), 22 with primary myelofibrosis (PMF) and four with MPN undifferentiated, were included in this study. European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC-QLQC30) and the MPN-Symptom Assessment Form (MPN-SAF) were used to evaluate QoL. Fatigue was the most reported symptom in these patients. Patients with PV reported significantly higher mean scores for inactivity, dizziness, cough, itching, depression and lower total QoL compared to patients with ET. Patients with PV had significantly more headache and itching compared to patients with PMF. When the newly diagnosed patients with MPN were compared with a cohort of patients with MPN with mean disease duration of 7.8 years, the differences were most striking for patients with PMF, with significantly more fatigue, abdominal discomfort, concentration problems, insomnia, fever, weight loss and lower overall QoL developed over time.
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| 2. |
- Alexander, Stephen P. H., et al.
(författare)
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The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
- 2023
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Ingår i: BRITISH JOURNAL OF PHARMACOLOGY. - : British pharmacological society. - 0007-1188 .- 1476-5381. ; 180
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Tidskriftsartikel (refereegranskat)abstract
- The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at . G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
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| 3. |
- Berghoff, Robyn, et al.
(författare)
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L1 activation during L2 processing is modulated by both age of acquisition and proficiency
- 2021
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Ingår i: Journal of Neurolinguistics. - : Elsevier BV. - 0911-6044 .- 1873-8052. ; 58
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Tidskriftsartikel (refereegranskat)abstract
- It is well established that access to the bilingual lexicon is non-selective: even in an entirely monolingual context, elements of the non-target language are active. Research has also shown that activation of the non-target language is greater at higher proficiency levels, suggesting that it may be proficiency that drives cross-language lexical activation. At the same time, the potential role of age of acquisition (AoA) in cross-language activation has gone largely unexplored, as most studies have either focused on adult L2 learners or have conflated AoA with L2 proficiency. The present study examines the roles of AoA and L2 proficiency in L2 lexical processing using the visual world paradigm. Participants were a group of early L1 Afrikaans-L2 English bilinguals (AoA 1-9 years) and a control group of L1 English speakers. Importantly, in the bilingual group, AoA and proficiency were not correlated. In the task, participants viewed a screen with four objects on it: a target object, a competitor object whose Afrikaans translation overlapped phonetically with the target object, and two unrelated distractor objects. The results show that the L2 English group was significantly more likely to look at the cross-language competitor than the L1 English group, thus providing evidence of cross-language activation. Importantly, the extent to which this activation occurred was modulated by both L2 proficiency and AoA. These findings suggest that while these two variables may have been confounded in previous research, they actually both exert effects on cross-language activation. The locus of this parallel activation effect is discussed in terms of connectionist models of bilingualism.
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| 4. |
- Berghoff, Robyn, et al.
(författare)
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L2 activation during L1 processing is increased by exposure but decreased by proficiency
- 2023
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Ingår i: International Journal of Bilingualism. - 1367-0069 .- 1756-6878.
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Tidskriftsartikel (refereegranskat)abstract
- Aims: The study investigates the effects of L2 proficiency and L2 exposure on L2-to-L1 cross-language activation (CLA) in L1-dominant bilinguals. In so doing, it tests the predictions made by prominent models of the bilingual lexicon regarding how language experience modulates CLA. Design: The participants (27 L1-dominant L1 English-L2 Afrikaans speakers) completed a visual world eye-tracking task, conducted entirely in English, in which they saw four objects on a screen: a target object, which they were instructed to click on; a competitor object, whose Afrikaans label overlapped phonetically at onset with the English target object label; and two unrelated distractors. Language background data were collected using the Language History Questionnaire 3.0. Analysis: A growth curve analysis was performed to investigate the extent to which the background variables modulated looks to the Afrikaans competitor item versus to the two unrelated distractor items. Findings: Increased L2 exposure was associated with greater CLA, which is consistent with models suggesting that exposure modulates the likelihood and speed with which a linguistic item becomes activated. Moreover, CLA was reduced at higher levels of L2 proficiency, which aligns with accounts of the bilingual lexicon positing that parasitism of the L2 on the L1 is reduced at higher proficiency levels, leading to reduced CLA. Originality: L2 activation during L1 processing and the variables that modulate it are not well documented, particularly among L1 speakers with limited proficiency in and exposure to the L2. Significance: The findings contribute to the evaluation of competing accounts of bilingual lexical organization.
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| 5. |
- Bylund, Emanuel, 1979-, et al.
(författare)
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Linguistic and geographic diversity in research on second language acquisition and multilingualism : An analysis of selected journals
- 2023
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Ingår i: Applied Linguistics. - 0142-6001 .- 1477-450X.
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Tidskriftsartikel (refereegranskat)abstract
- The present study assesses linguistic and geographic diversity in selected outlets of SLA and multilingualism research. Specifically, we examine over 2,000 articles published in specialized top-tier journals, recording the languages under study and their acquisition order, author affiliations, the country in which the research was conducted, and citations. In the sample, there were 183 unique languages and 174 unique pairings, corresponding to 3 per cent of the world’s 7,000 languages and less than 0.001 per cent of 24.5 million possible language combinations. English was overwhelmingly the most common language, followed by Spanish and Mandarin Chinese. North America and Western Europe were both the main producers of knowledge and the main sites for research on multilingualism in the sample. Crucially, the regions with the highest levels of linguistic diversity and societal multilingualism (typically the Global South) were only marginally represented. The findings also show that studies on English and northern Anglophone settings were likely to elicit more citations than studies on other languages and settings, and that less studied languages were included more frequently in article titles.
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| 6. |
- Christopoulos, Arthur, et al.
(författare)
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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors.
- 2021
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Ingår i: British journal of pharmacology. - : Wiley. - 1476-5381 .- 0007-1188. ; 178 Suppl 1
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Forskningsöversikt (refereegranskat)abstract
- The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15538. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
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| 7. |
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| 8. |
- Emanuel, Robyn M, et al.
(författare)
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Myeloproliferative Neoplasm (MPN) Symptom Assessment Form Total Symptom Score : Prospective International Assessment of an Abbreviated Symptom Burden Scoring System Among Patients With MPNs
- 2012
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Ingår i: Journal of Clinical Oncology. - 0732-183X .- 1527-7755. ; 30:33, s. 4098-4103
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE Myeloproliferative neoplasm (MPN) symptoms are troublesome to patients, and alleviation of this burden represents a paramount treatment objective in the development of MPN-directed therapies. We aimed to assess the utility of an abbreviated symptom score for the most pertinent and representative MPN symptoms for subsequent serial use in assessing response to therapy.PATIENTS AND METHODSThe Myeloproliferative Neoplasm Symptom Assessment Form total symptom score (MPN-SAF TSS) was calculated as the mean score for 10 items from two previously validated scoring systems. Questions focus on fatigue, concentration, early satiety, inactivity, night sweats, itching, bone pain, abdominal discomfort, weight loss, and fevers.RESULTS MPN-SAF TSS was calculable for 1,408 of 1,433 patients with MPNs who had a mean score of 21.2 (standard deviation [SD], 16.3). MPN-SAF TSS results significantly differed among MPN disease subtypes (P < .001), with a mean of 18.7 (SD, 15.3), 21.8 (SD, 16.3), and 25.3 (SD, 17.2) for patients with essential thrombocythemia, polycythemia vera, and myelofibrosis, respectively. The MPN-SAF TSS strongly correlated with overall quality of life (QOL; r = 0.59; P < .001) and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) functional scales (all P < .001 and absolute r ≥ 0.50 except social functioning r = 0.48). No significant trends were present when comparing therapy subgroups. The MPN-SAF TSS had excellent internal consistency (Cronbach's α = .83). Factor analysis identified a single underlying construct, indicating that the MPN-SAF TSS is an appropriate, unified scoring method.CONCLUSIONThe MPN-SAF TSS is a concise, valid, and accurate assessment of MPN symptom burden with demonstrated clinical utility in the largest prospective MPN symptom study to date. This new prospective scoring method may be used to assess MPN symptom burden in both clinical practice and trial settings.
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