| 1. |
- Ekström, Magnus, et al.
(författare)
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Exertional breathlessness related to medical conditions in middle-aged people: the population-based SCAPIS study of more than 25,000 men and women.
- 2024
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Ingår i: Respiratory research. - : BioMed Central (BMC). - 1465-993X .- 1465-9921. ; 25:1
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Tidskriftsartikel (refereegranskat)abstract
- Breathlessness is common in the population and can be related to a range of medical conditions. We aimed to evaluate the burden of breathlessness related to different medical conditions in a middle-aged population.Cross-sectional analysis of the population-based Swedish CArdioPulmonary bioImage Study of adults aged 50-64years. Breathlessness (modified Medical Research Council [mMRC]≥2) was evaluated in relation to self-reported symptoms, stress, depression; physician-diagnosed conditions; measured body mass index (BMI), spirometry, venous haemoglobin concentration, coronary artery calcification and stenosis [computer tomography (CT) angiography], and pulmonary emphysema (high-resolution CT). For each condition, the prevalence and breathlessness population attributable fraction (PAF) were calculated, overall and by sex, smoking history, and presence/absence of self-reported cardiorespiratory disease.We included 25,948 people aged 57.5±[SD] 4.4; 51% women; 37% former and 12% current smokers; 43% overweight (BMI 25.0-29.9), 21% obese (BMI≥30); 25% with respiratory disease, 14% depression, 9% cardiac disease, and 3% anemia. Breathlessness was present in 3.7%. Medical conditions most strongly related to the breathlessness prevalence were (PAF 95%CI): overweight and obesity (59.6-66.0%), stress (31.6-76.8%), respiratory disease (20.1-37.1%), depression (17.1-26.6%), cardiac disease (6.3-12.7%), anemia (0.8-3.3%), and peripheral arterial disease (0.3-0.8%). Stress was the main factor in women and current smokers.Breathlessness mainly relates to overweight/obesity and stress and to a lesser extent to comorbidities like respiratory, depressive, and cardiac disorders among middle-aged people in a high-income setting-supporting the importance of lifestyle interventions to reduce the burden of breathlessness in the population.
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| 2. |
- Bergström Lind, Sara, et al.
(författare)
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Immunoaffinity Enrichments Followed by Mass Spectrometric Detection for Studying Global Protein Tyrosine Phosphorylation
- 2008
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Ingår i: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 7:7, s. 2897-2910
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Tidskriftsartikel (refereegranskat)abstract
- Phosphorylation of protein tyrosine residues regulates important cell functions and is, when dysregulated, often crucially involved in oncogenesis. It is therefore important to develop and evaluate methods for identifying and studying tyrosine phosphorylated (P-Tyr) proteins. P-Tyr proteins are present at very low concentrations within cells, requiring highly selective enrichment methods to be detected. In this study, we applied immunoaffinity as enrichment step for P-Tyr proteins. Five selected anti-phosphotyrosine antibodies (monoclonal antibodies 4G10, PY100, PYKD1, 13F9 and one polyclonal antiserum) were evaluated with respect to their capability to enrich P-Tyr proteins from cell extracts of the K562 leukemia cell line. The enrichment resulted in the detection of a group of proteins that potentially were tyrosine-phosphorylated (putative P-Tyr proteins). High accuracy identification of actual P-Tyr sites were performed using a highly selective and sensitive liquid chromatography Fourier transform mass spectrometer (LC-FTMS) setup with complementary collision activated dissociation (CAD) and electron capture dissociation (ECD) fragmentations. 4G10 and PY100 antibodies recognized the greatest number of putative P-Tyr proteins in initial screening experiments and were therefore further evaluated and compared in immunoaffinity enrichment of both P-Tyr proteins and peptides. Using the 4G10 antibody for enrichment of proteins, we identified 459 putative P-Tyr proteins by MS. Out of these proteins, 12 were directly verified as P-Tyr proteins by MS analysis of the actual site. Using the PY100 antibody for enrichment of peptides, we detected 67 P-Tyr peptides (sites) and 89 putative P-Tyr proteins. Generally, enrichment at the peptide level made it difficult to reliably determine the identity of the proteins. In contrast, protein identification following immunoaffinity enrichment at the protein level gave greater sequence coverage and thus a higher confidence in the protein identification. By combining all available information, 40 proteins were identified as true P-Tyr proteins from the K562 cell line. In conclusion, this study showed that a combination of immunoaffinity enrichment using multiple antibodies of both intact and digested proteins in parallel experiments is required for best possible coverage of all possible P-Tyr proteins in a sample.
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| 3. |
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| 4. |
- Dahlström, Örjan, 1973-, et al.
(författare)
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Does retrieval strategy disruption cause general and specific collaborative inhibition?
- 2011
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Ingår i: Memory. - : Taylor and Francis. - 0965-8211 .- 1464-0686. ; 19:2, s. 140-154
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of the experiment on collaborative memory was to investigate if the collaborative inhibition is due to collaborating pair's disruption of each others' retrieval strategies (the retrieval strategy disruption hypothesis, RSD). The participants' (N=36) task was to recall a list of 60 words individually and collaboratively. Retrieval strategies were manipulated by presenting word lists organised either by categories or by country of origin and adoption of retrieval strategies were examined by the adjusted ratio of clustering score. Half of the dyads received word lists organised by the same strategy and half of the dyads received word lists organised by different strategies. The results revealed a main effect of collaboration, i.e., collaborative recalled items were significantly fewer than the sum of the non-redundant individually recalled items. Both conditions (same strategies vs different strategies) suffered to the same extent from collaboration, which did not support the RSD hypothesis. However, focusing on words recalled individually but not collaboratively, dyads with different strategies, as predicted by the RSD, forgot more items during collaboration than did dyads with the same strategy. Additional results suggest that collaborative forgetting is mainly manifested by forgetting of non-overlapping items (as measured by individual recalls).
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| 5. |
- Danielsson, Henrik, et al.
(författare)
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Opposites accord : Effects of individual performance variations on collaborative memory performance
- 2009
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Konferensbidrag (refereegranskat)abstract
- Collaborative memory is traditionally assessed among persons with presumed equal memory capability, which is not always true in ecological settings. We have investigated collaborative memory performances both when a difference in memory performance within the pair is provoked and when it is not. This was manipulated by different encoding times in a within participant design. 20 pairs were presented with a word list for later recall. The word list was firstly recalled individually and afterwards collaboratively for both memory difference conditions. Nominal recall (the sum of the individual nonredundant performances) and collaborative recall was calculated. An interaction between type of recall and difference in memory performance was found, where collaborative recall at same memory performance was especially impaired by net negative effects of collaboration. These results are discussed in relation to item analysis of which words were recalled.
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| 6. |
- de Moor, Joost, et al.
(författare)
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Country reports: Sweden
- 2019
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Ingår i: Protest for a future. - Bryssel : Confederation Syndicat European Trade Union. ; , s. 19-31, s. 96-111
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 7. |
- Edwards, Ylva, et al.
(författare)
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Quality-assured solutions for green roof gardens on concrete deck with zero tolerance for leaks
- 2016
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Ingår i: WIT Transactions on Ecology and the Environment. - : WIT Press. ; 204, s. 363-372
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Konferensbidrag (refereegranskat)abstract
- Eco-neighborhoods with gardens on concrete decks are for several reasons increasingly being prescribed today in major Swedish cities. However, there is a lack of knowledge, experience, standards and guidelines as well as collaboration between parties and stakeholders when installing such systems. It is incredibly important to avoid any leakage during the lifetime of a green roof garden but this cannot be completely guaranteed with today’s installation practice and project management. At Sustainable City 2014 in Siena, we presented a paper about a new project aiming at bringing together researchers, government and industry to collaborative development of new and attractive solutions for green roof gardens with consideration to the environment and high requirements for durability, materials, construction and energy efficiency. This paper is a continuation of the paper presented in Siena and reports on the most recent results from the collaborative project which will finalize in November 2016. After that, the project will be further evaluated in a proposed continuation project for another couple of years.
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| 8. |
- Emilsson, Kajsa, et al.
(författare)
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Frame Disputes or Frame Consensus? : "Environment" or "Welfare" First Amongst Climate Strike Protesters
- 2020
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Ingår i: Sustainability. - : MDPI. - 2071-1050. ; 12:3
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Tidskriftsartikel (refereegranskat)abstract
- Present debates suppose a close linkage between economic, social, and environmental sustainability and suggest that individual wellbeing and living standards need to be understood as directly linked to environmental concerns. Because social movements are often seen as an avant-garde in pushing for change, this article analyzes climate protesters’ support for three key frames in current periods of social transformation, i.e., an "environmental", an "economic growth", and a "welfare" frame. The analyzed data material consists of survey responses from over 900 participants in six Global Climate Strikes held in Sweden during 2019. The article investigates the explanatory relevance of three factors: (a) political and ideological orientation, (b) movement involvement, and (c) social characteristics. The results indicate that climate protesters to a large degree support an environmental frame before an economic growth-oriented frame, whereas the situation is more complex regarding support for a welfare frame vis-á-vis an environmental frame. The strongest factors explaining frame support include social characteristics (gender) and protestors’ political and ideological orientation. Movement involvement has limited significance. The article shows how these frames form a fragment of the complexity of these issues, and instances of frame distinctions, hierarchies, and disputes emerge within the most current forms of climate change demonstrations.
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| 9. |
- Emilsson, Louise, et al.
(författare)
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Colorectal cancer death after adenoma removal in Scandinavia
- 2017
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Ingår i: Scandinavian Journal of Gastroenterology. - Oxfordshire, United Kingdom : Taylor & Francis. - 0036-5521 .- 1502-7708. ; 52:12, s. 1377-1384
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: Improved understanding of the subsequent risk death from colorectal cancer (CRC) among individuals who had adenomas removed is needed. We aimed to quantify this risk using prospectively collected data from population-based cohorts.MATERIALS AND METHODS: Using Norwegian and Swedish registries, a cohort of 90,864 individuals with colorectal adenomas removed between 1980 and 2013 was identified. Surveillance was only recommended for high-risk adenomas. The validity of the registry data did not allow classification into low- and high-risk adenomas. Virtually complete follow-up was achieved through linkage to nationwide registers. We calculated incidence-based standardised mortality ratios (SMRs) with 95% confidence intervals (CI).RESULTS: The median follow-up was 7.2 years; 48,058 individuals were followed for more than 10 years. We observed 819 deaths (0.9%) from CRC and expected 731 CRC deaths (0.8%), corresponding to an absolute excess risk of 88 cases (0.1%) and a relative risk of 12% (SMR 1.12; 95%CI 1.05-1.20). The relative risk of CRC death following adenoma removal was slightly higher in Sweden (SMR 1.22; 95%CI 1.11-1.34) than in Norway (SMR 1.03; 95%CI 0.93-1.14), and higher in women (SMR 1.24; 95%CI 1.12-1.36) than in men (SMR 1.02; 95%CI 0.93-1.13). Among individuals with more than 10 years of follow-up, the estimates were similar to the overall cohort, absolute excess risk 0.1% (SMR 1.15; 95%CI 1.06-1.24).CONCLUSION: The excess risk of CRC death following adenoma removal is small. Optimal surveillance recommendations should be tested in randomised trials.
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| 10. |
- Emilsson, Össur Ingi, et al.
(författare)
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Heritability of cough across two generations : the RHINESSA study.
- 2024
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Ingår i: ERJ open research. - : European Respiratory Society. - 2312-0541. ; 10:4
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Tidskriftsartikel (refereegranskat)abstract
- AIM: Heritability of cough has not yet been studied. We aimed to evaluate if individuals with cough are more likely to have offspring who develop cough, and if these associations differ by type of cough (productive/nonproductive).METHODS: The RHINESSA Generation Study (Respiratory Health In Northern Europe, Spain and Australia) includes 7155 parents (initially aged 30-54) answering detailed questionnaires in 2000 and 2010, and 8176 offspring ≥20 years answering similar questionnaires in 2012-2019. Chronic cough was categorised as productive or nonproductive (dry) cough. Associations between parental and offspring cough were analysed using mixed-effects logistic regression, adjusting for offspring age, sex, body mass index, smoking history, education level, current asthma, rhinitis, nocturnal gastroesophageal reflux; parent sex and smoking history; centre and family.RESULTS: Among parents with nonproductive cough, 11% of their offspring reported nonproductive cough, compared with 7% of offspring to parents without nonproductive cough, adjusted odds ratio (aOR) 1.59 (95% confidence interval 1.20-2.10). Among parents with productive cough, 14% of their offspring reported productive cough, compared with 11% of offspring to parents without productive cough, aOR 1.34 (1.07-1.67). No associations were found between parent productive cough-offspring nonproductive cough, nor between parent nonproductive cough-offspring productive cough.CONCLUSIONS: Parents with chronic cough are more likely to have offspring with chronic cough independent of parental asthma, suggesting cough to be a separate heritable trait. The type of cough is important, as the nonproductive cough in parent associates only with nonproductive cough in offspring, and the same applied for productive cough.
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