| 1. |
- Elks, Cathy E, et al.
(författare)
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Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:12, s. 1077-85
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Tidskriftsartikel (refereegranskat)abstract
- To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10⁻⁶⁰) and 9q31.2 (P = 2.2 × 10⁻³³), we identified 30 new menarche loci (all P < 5 × 10⁻⁸) and found suggestive evidence for a further 10 loci (P < 1.9 × 10⁻⁶). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.
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| 2. |
- Tucker, S., et al.
(författare)
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Improving the mix of institutional and community care for older people with dementia : an application of the balance of care approach in eight European countries
- 2016
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Ingår i: Aging and Mental Health. - Abingdon : Informa UK Limited. - 1360-7863 .- 1364-6915. ; 20:12, s. 1327-1338
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To examine whether the mix of community and institutional long-term care (ILTC) for people with dementia (PwD) in Europe could be improved; assess the economic consequences of providing alternative services for particular groups of ILTC entrants and explore the transnational application of the ‘Balance of Care’ (BoC) approach. Method: A BoC study was undertaken in Estonia, Finland, France, Germany, the Netherlands, Spain, Sweden, and the UK as part of the RightTimePlaceCare project. Drawing on information about 2014 PwD on the margins of ILTC admission, this strategic planning framework identified people whose needs could be met in more than one setting, and compared the relative costs of the possible alternatives. Results: The findings suggest a noteworthy minority of ILTC entrants could be more appropriately supported in the community if enhanced services were available. This would not necessarily require innovative services, but more standard care (including personal and day care), assuming quality was ensured. Potential cost savings were identified in all countries, but community care was not always cheaper than ILTC and the ability to release resources varied between nations. Conclusions: This is believed to be the first transnational application of the BoC approach, and demonstrates its potential to provide a consistent approach to planning across different health and social care systems. Better comparative information is needed on the number of ILTC entrants with dementia, unit costs and outcomes. Nevertheless, the findings offer important evidence on the appropriateness of current provision, and the opportunity to learn from different countries' experience.
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| 3. |
- Hallberg, Ingalill R, et al.
(författare)
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Structure of long term home and institutional care systems in Europe
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this part of the RightTimePlaceCare study (WP2) was to describe and analyse the European health, social care and welfare systems, advocacy and informal caregiver support systems for patients with dementia. The description and analyses covers the continuum of care from diagnosis, informal care, contributions from civic society, public home care and the intermediate forms of care, to the long-term institutionalised care, and end of life care. In a first step, the terminology was developed and meanings of different terms used in relation to dementia care were collected, analysed, defined and categorised. Thereafter the terminology was used to develop a template organised on the Y-axis as being the course of the dementia disease as described by the OECD in 2004, and on the X-axis as being the type of care provided, organised in accordance with the process of the disease from dementia screening to end of life care. In addition each country was asked to provide an overall description of the care system they offered with regard to the national directives and financing of their dementia care system. The primary source of information was written reports from different sources. Official documents, epidemiological studies and descriptions of the care system, in particular dementia care system offered in their country. In addition interviews with responsible managers, providers or the equivalent in relevant care and service organisations, with persons in consumer/user organisations, with staff, professional employees and purchasers in a municipality or another representative for a civic administrative area were recommended.
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| 4. |
- Karlsson, Staffan, 1959-, et al.
(författare)
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Institutional care for older people with dementia in an European perspective
- 2013
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Ingår i: The Journal of Nutrition, Health & Aging. - Heidelberg : Springer. - 1279-7707 .- 1760-4788. ; 17:Suppl. 1, s. S419-S419
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Cognitive impairment has been found to be a main predictor for institutionalization. Various types of institutional care are available for persons with dementia, but knowledge is sparse about how the institution should be designed and scaled, and if it should be specialised in dementia or mixed with other older people. To explore various types of institutional care for older people with dementia in eight European countries.Method: Estonia, Finland, France, Germany, Netherlands, Spain, Sweden and UK were included in the study. A template was developed for collecting data among other areas also about various institutional care. Terminology was reviewed by experts and agreed between the countries. The template covers 50 types of care provided in relation to the dementia trajectory, from diagnosis to end of life stage. Questions about various types of institutional care were analysed. Each question covered estimation of availability, utilization and professionals involved.Results: In the description of the care system, preliminary results showed that residential home or nursing home not specifically organised for persons with dementia was the most common institution through all stages. Institutions more specialised in dementia care was less common and mostly available for those in moderate to end of life stage. The professionals were more educated in dementia in the specialised institutions compared to non specialised institutions.Conclusion: For people with dementia disease, institutions not specific for those with dementia were common in all eight countries, while institutions more specialised were available for few. On the behalf of RightTimePlaceCare consortium. http://www.righttimeplacecare.eu
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