| 1. |
- Ene, Daniela, et al.
(författare)
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Management of Tritium in European Spallation Source
- 2015
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Ingår i: Fusion Science and Technology. - 1536-1055. ; 67:2, s. 324-327
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Tidskriftsartikel (refereegranskat)abstract
- The European Spallation Source (ESS) will produce tritium via spallation and activation processes during operational activities. Within the location of ESS facility in Lund, Sweden site it is mandatory to demonstrate that the management strategy of the produced tritium ensures the compliance with the country regulation criteria. The aim of this paper is to give an overview of the different aspects of the tritium management in ESS facility. Besides the design parameter study of the helium coolant purification system of the target the consequences of the tritium releasing into the environment were also analyzed. Calculations shown that the annual release of tritium during the normal operations represents a small fraction from the estimated total dose. However, more refined calculations of migration of activated-groundwater should be performed for higher hydraulic conductivities, with the availability of the results on soil examinations. With the assumption of 100% release of tritium to the atmosphere during the occurring of the extreme accidents, it was found as well that the total dose complies with the constraint.
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| 2. |
- Ene, Daniela
(författare)
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Preliminary Waste Management Plan of European Spallation Source
- 2013
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Ingår i: ASME 2013 15th International Conference on Environmental Remediation and Radioactive Waste Management, Vol 1: Low/intermediate-level Radioactive Waste Management; Spent Fuel, Fissile Material, Transuranic and High-level Radioactive Waste Management. - 9780791856017 ; , s. 001-029
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Konferensbidrag (refereegranskat)abstract
- The European Spallation Source (ESS) is the European common effort in designing and building a next generation large-scale user facility for studies of the structure and dynamics of materials. The proposed schematic layout of the ESS facility is based on a linear driver (linac) directing the proton beam (5 MW of 2.5 GeV) of 2.8 ms long pulses with a 20 Hz on a tungsten target where neutrons are produced via spallation reactions. Further the neutrons will be moderated to thermal and subthermal energies in a couple of moderators placed around the target. The moderators feed 22 beamlines guiding the neutrons to the scattering instruments, mainly for neutron scattering research, as has been previously mentioned. The objective of this work is to develop a waste management plan for ESS facility. In this respect two important aspects are analyzed. First the present status of the problem is outlined as follow. Estimate types and quantities of waste that the ESS project will generate at different stages: commission, operation, decommissioning were derived using: i) precise Monte Carlo calculations ii) scaling the activity from the operation experience of the existing spallation source installations for waste such it is difficult to predict level of activation or for components of the facility in stage of the pre-conceptual model. Associated waste treatment/conditioning options and final disposal route were further analyzed in order to define the waste type and packet descriptions in agreement with Swedish regulations and policy. It was found that the compilation of completely new waste type descriptions for qualification of the ESS waste for disposal will be necessary. Particular attention was devoted to "problematic waste" as Beryllium reflector, C-14 from graphite used as core zone of the beam-dump and collimators or waste arising from the purification systems of both Helium and water cooling circuits. Management of waste on ESS site: collection/segregation systems, characterization system, storage options, is also described. In the second step, the acquired information is used for planning and implementing actions involving all participants (ESS, treatment facility operator, disposal operator, regulatory body and other authorized authorities).
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| 3. |
- Fang, Li Tai, et al.
(författare)
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Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing
- 2021
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Ingår i: Nature Biotechnology. - : Springer Nature. - 1087-0156 .- 1546-1696. ; 39:9, s. 1151-1160
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Tidskriftsartikel (refereegranskat)abstract
- Tumor-normal paired DNA samples from a breast cancer cell line and a matched lymphoblastoid cell line enable calibration of clinical sequencing pipelines and benchmarking 'tumor-only' or 'matched tumor-normal' analyses. The lack of samples for generating standardized DNA datasets for setting up a sequencing pipeline or benchmarking the performance of different algorithms limits the implementation and uptake of cancer genomics. Here, we describe reference call sets obtained from paired tumor-normal genomic DNA (gDNA) samples derived from a breast cancer cell line-which is highly heterogeneous, with an aneuploid genome, and enriched in somatic alterations-and a matched lymphoblastoid cell line. We partially validated both somatic mutations and germline variants in these call sets via whole-exome sequencing (WES) with different sequencing platforms and targeted sequencing with >2,000-fold coverage, spanning 82% of genomic regions with high confidence. Although the gDNA reference samples are not representative of primary cancer cells from a clinical sample, when setting up a sequencing pipeline, they not only minimize potential biases from technologies, assays and informatics but also provide a unique resource for benchmarking 'tumor-only' or 'matched tumor-normal' analyses.
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| 4. |
- Konobeyev, A. Yu., et al.
(författare)
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Evaluated Activation Cross Section Data for Proton Induced Nuclear Reactions on W up to 3 GeV Incident Energy
- 2014
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Ingår i: Nuclear Data Sheets. - : Elsevier BV. - 0090-3752. ; 118, s. 112-114
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Tidskriftsartikel (refereegranskat)abstract
- Evaluated cross-section data files were prepared for stable tungsten isotopes with the objective to provide reliable and sound nuclear data for activation and inventory calculations of the European Spallation Source, which utilizes a tungsten target. The data files contain yields of radionuclides produced by proton induced reactions with incident energies up to 3 GeV. The calculations of cross-sections were performed using the intranuclear cascade model, the pre-equilibrium exciton model, and the Hauser-Feshbach model. The available experimental information, results of calculations and systematics were applied for the evaluation of yields of residual nuclei using statistical methods implemented in the computer code package BEKED developed at KIT.
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| 5. |
- Zhao, Yongmei, et al.
(författare)
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Whole genome and exome sequencing reference datasets from a multi-center and cross-platform benchmark study
- 2021
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Ingår i: Scientific Data. - : Springer Nature. - 2052-4463. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- With the rapid advancement of sequencing technologies, next generation sequencing (NGS) analysis has been widely applied in cancer genomics research. More recently, NGS has been adopted in clinical oncology to advance personalized medicine. Clinical applications of precision oncology require accurate tests that can distinguish tumor-specific mutations from artifacts introduced during NGS processes or data analysis. Therefore, there is an urgent need to develop best practices in cancer mutation detection using NGS and the need for standard reference data sets for systematically measuring accuracy and reproducibility across platforms and methods. Within the SEQC2 consortium context, we established paired tumor-normal reference samples and generated whole-genome (WGS) and whole-exome sequencing (WES) data using sixteen library protocols, seven sequencing platforms at six different centers. We systematically interrogated somatic mutations in the reference samples to identify factors affecting detection reproducibility and accuracy in cancer genomes. These large cross-platform/site WGS and WES datasets using well-characterized reference samples will represent a powerful resource for benchmarking NGS technologies, bioinformatics pipelines, and for the cancer genomics studies.
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| 6. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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