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- Birgegård, Gunnar, 1944-, et al.
(författare)
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Inflammatory functional iron deficiency common in myelofibrosis, contributes to anaemia and impairs quality of life. From the Nordic MPN study Group
- 2019
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Ingår i: European Journal of Haematology. - : Munksgaard Forlag. - 0902-4441 .- 1600-0609. ; 102:3, s. 235-240
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: The study investigates the hypothesis that inflammation in myelofibrosis (MF) like in myeloma and lymphoma, may disturb iron distribution and contribute to anaemia.METHODS: A cross-sectional study of 80 MF and 23 ET patients was performed.RESULTS: About 35% of anaemic MF patients had functional iron deficiency (FID) with transferrin saturation <20 and normal or elevated S-ferritin (<500 µg/L). In ET, FID was rare. In MF patients with FID, 70.6% were anaemic, vs 29.4% in patients without FID (P = 0.03). Hepcidin was significantly higher in MF patients with anaemia, including transfusion-dependent patients, 50.6 vs 24.4 µg/L (P = 0.01). There was a significant negative correlation between Hb and inflammatory markers in all MF patients: IL-2, IL-6 and TNF-α, (P < 0.01-0.03), LD (P = 0.004) and hepcidin (P = 0.03). These correlations were also seen in the subgroup of anaemic MF patients (Table ). Tsat correlated negatively with CRP (P < 0.001). Symptom burden was heavier in MF patients with FID, and MPN-SAF quality of life scores correlated with IL-6 and CRP.CONCLUSIONS: The inflammatory state of MF disturbs iron turnover, FID is common and contributes to anaemia development and impairment of QoL. Anaemic MF patients should be screened for FID.
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| 2. |
- Coenen, Marieke J H, et al.
(författare)
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Genetic Variants in Toll-Like Receptors Are Not Associated with Rheumatoid Arthritis Susceptibility or Anti-Tumour Necrosis Factor Treatment Outcome
- 2010
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 5:12
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Tidskriftsartikel (refereegranskat)abstract
- Background: Several studies point to a role of Toll-like receptors (TLRs) in the development of rheumatoid arthritis (RA). We investigated if genetic variants in TLR genes are associated with RA and response to tumour necrosis factor blocking (anti-TNF) medication. Methodology and Principal Findings: 22 single nucleotide polymorphisms (SNPs) in seven TLR genes were genotyped in a Dutch cohort consisting of 378 RA patients and 294 controls. Significantly associated variants were investigated in replication cohorts from The Netherlands, United Kingdom and Sweden (2877 RA patients and 2025 controls). 182 of the Dutch patients were treated with anti-TNF medication. Using these patients and a replication cohort (269 Swedish patients) we analysed if genetic variants in TLR genes were associated with anti-TNF outcome. In the discovery phase of the study we found a significant association of SNPs rs2072493 in TLR5 and rs3853839 in TLR7 with RA disease susceptibility. Meta-analysis of discovery and replication cohorts did not confirm these findings. SNP rs2072493 in TLR5 was associated with anti-TNF outcome in the Dutch but not in the Swedish population. Conclusion: We conclude that genetic variants in TLRs do not play a major role in susceptibility for developing RA nor in anti-TNF treatment outcome in a Caucasian population.
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| 3. |
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| 4. |
- Enevold, Jenny, 1981-
(författare)
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Structure and morphology control of organic semiconductors for functional optoelectronic applications
- 2019
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The functionality and application of organic semiconductors are largely dependent on their constituent structure and morphology. This thesis presents a number of functional and novel approaches for the control and tuning of structural and morphological features of a variety of organic semiconductor materials, and also demonstrates that these approaches can be utilized for improved device operation of field-effect transistors, organic solar cells and light-emitting electrochemical cells.The fullerene family is a particular group of closed-cage organic semiconductors, which can be photochemically coupled into larger dimeric or polymeric structures through the excitation of the fullerene molecules by light emission. In Paper I, we perform a detailed experimental and analytical investigation, which demonstrates that this photochemical monomer-to-dimer transformation requires that both constituent fullerene molecules are photoexcited. The direct consequence is that the initial probability for the photochemical transformation is dependent on the square of the light-emission intensity.The photochemical coupling of fullerene molecules commonly results in a distinctly lowered solubility in common hydrophobic solvents, which can be utilized for the direct patterning of fullerene films by resist-free lithography. In Paper II, we utilize this patterning opportunity for the fabrication of one-dimensional fullerene nano-stripes using two-beam laser interference lithography. A desired high contrast between the patterned and non-patterned fullerene regions is facilitated by the non-linear response of the photochemical transformation process, as predicted by the findings in Paper I. The patterned fullerene nano-stripes were utilized as the active material in field-effect transistors, which featured high electron mobility and large on-off ratio.This patterning was in Paper III extended into easy tunable two-dimensional fullerene structures by the design and development of an exposure setup, essentially comprising a laser and a spatial light modulator featuring >8 millions of independently controlled mirrors. With this approach, we could fabricate well-defined fullerene microdots over a several square-millimeter sized area, which was utilized as an internal out-coupling layer in a light-emitting electrochemical cell with significantly enhanced light output.Paper IV reports on the development of a new “spray-sintering” method for the cost-efficient solution-based deposition of the active material in light-emitting electrochemical cells. This carefully designed approach effectively resolves the issue with phase separation between the hydrophobic organic semiconductor and the hydrophilic electrolyte that results in a sub-par LEC performance, and also allows for the direct fabrication of LEC devices onto complex surfaces, including a stainless-steel fork.Paper V finally reports on the design and synthesis of a soluble small molecule, featuring a donor-acceptor-donor configuration. It acts as the donor when combined with a soluble fullerene acceptor in the active material of organic solar cells, and such devices with optimized donor/acceptor nanomorphology feature a high open-circuit voltage of ~1.0 V during solar illumination.
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| 5. |
- Iqbal, Javed, et al.
(författare)
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An arylene-vinylene based donor-acceptor-donor small molecule for the donor compound in high-voltage organic solar cells
- 2016
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Ingår i: Solar Energy Materials and Solar Cells. - : Elsevier BV. - 0927-0248 .- 1879-3398. ; 155, s. 348-355
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Tidskriftsartikel (refereegranskat)abstract
- A donor-acceptor-donor (D-A-D) molecule has been designed and synthesized for use as the electron donating material in solution-processed small-molecule organic solar cells (OSCs). The D-A-D molecule comprises a central electron-accepting (2Z,2'Z)-2,2'-(2,5-bis(octyloxy)-1,4-phenylene)bis(3-(thiophen-2-yl)acry lonitrile) (ZOPTAN) core, which is chemically connected to two peripheral and electron-donating triphenylamine (TPA) units. The ZOPTAN-TPA molecule features a low HOMO level of -5.2 eV and an optical energy gap of 2.1 eV. Champion OSCs based on a solution-processed and non-annealed active material blend of [6,6]-phenyl-C-61-butyric acid methyl ester (PCBM) and ZOPTAN-TPA in a mass ratio of 2:1 exhibits a power conversion efficiency of 1.9% and a high open-circuit voltage of 1.0 V.
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| 6. |
- Vandamme, Peter, et al.
(författare)
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Burkholderia bryophila sp nov and Burkholderia megapolitana sp nov., moss-associated species with antifungal and plant-growth-promoting properties
- 2007
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Ingår i: INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY. - : Microbiology Society. - 1466-5026 .- 1466-5034. ; 57, s. 2228-2235
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Tidskriftsartikel (refereegranskat)abstract
- A polyphasic taxonomic study including DNA–DNA reassociation experiments and an extensive biochemical characterization was performed on 14 Burkholderia isolates from moss gametophytes of nutrient-poor plant communities on the southern Baltic Sea coast in northern Germany. The strains were classified within two novel species, for which the names Burkholderia bryophila sp. nov. and Burkholderia megapolitana sp. nov. are proposed. The former species also includes isolates from grassland and agricultural soil collected in previous studies. Strains Burkholderia bryophila 1S18T (=LMG 23644T =CCUG 52993T) and Burkholderia megapolitana A3T (=LMG 23650T =CCUG 53006T) are the proposed type strains. They were isolated from Sphagnum rubellum and Aulacomnium palustre, respectively, growing in the ‘Ribnitzer Großes Moor’ nature reserve (Mecklenburg-Pommern, Germany). All moss isolates of both novel species showed antifungal activity against phytopathogens as well as plant-growth-promoting properties.
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