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Sökning: WFRF:(Engqvist Jonas)

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1.
  • Nordblom, Jonathan, et al. (författare)
  • FGF1 containing biodegradable device with peripheral nerve grafts induces corticospinal tract regeneration and motor evoked potentials after spinal cord resection
  • 2012
  • Ingår i: Restorative Neurology and Neuroscience. - 0922-6028 .- 1878-3627. ; 30:2, s. 91-102
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: Repairing the spinal cord with peripheral nerve grafts (PNG) and adjuvant acidic fibroblast growth factor (FGF1) has previously resulted in partial functional recovery. To aid microsurgical placement of PNGs, a graft holder device was previously developed by our group. In hope for a translational development we now investigate a new biodegradable graft holder device containing PNGs with or without FGF1.Methods: Rats were subjected to a T11 spinal cord resection with subsequent repair using twelve white-to-grey matter oriented PNGs prepositioned in a biodegradable device with or without slow release of FGF1. Animals were evaluated with BBB-score, electrophysiology and immunohistochemistry including anterograde BDA tracing.Results: Motor evoked potentials (MEP) in the lower limb reappeared at 20 weeks after grafting. MEP responses were further improved in the group treated with adjuvant FGF1. Reappearance of MEPs was paralleled by NF-positive fibers and anterogradely traced corticospinal fibers distal to the injury. BBB-scores improved in repaired animals.Conclusions: The results continue to support that the combination of PNGs and FGF1 may be a regeneration strategy to reinnervate the caudal spinal cord. The new device induced robust MEPs augmented by FGF1, and may be considered for translational research.
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2.
  • Aberg, Jonas, et al. (författare)
  • In vivo evaluation of an injectable premixed radiopaque calcium phosphate cement.
  • 2011
  • Ingår i: International journal of biomaterials. - : Hindawi Limited. - 1687-8795 .- 1687-8787. ; 2011
  • Tidskriftsartikel (refereegranskat)abstract
    • In this work a radiopaque premixed calcium phosphate cement (pCPC) has been developed and evaluated in vivo. Radiopacity was obtained by adding 0-40 % zirconia to the cement paste. The effects of zirconia on setting time, strength and radiopacity were evaluated. In the in vivo study a 2 by 3.5mm cylindrical defect in a rat vertebrae was filled with either the pCPC, PMMA or bone chips. Nano-SPECT CT analysis was used to monitor osteoblast activity during bone regeneration. The study showed that by adding zirconia to the cement the setting time becomes longer and the compressive strength is reduced. All materials evaluated in the in vivo study filled the bone defect and there was a strong osteoblast activity at the injury site. In spite of the osteoblast activity, PMMA blocked bone healing and the bone chips group showed minimal new bone formation. At 12 weeks the pCPC was partially resorbed and replaced by new bone with good bone ingrowth. The radiopaque pCPC may be considered to be used for minimal invasive treatment of vertebral fractures since it has good handling, radiopacity and allows healing of cancellous bone in parallel with the resorption of the cement.
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3.
  • Athanasopoulos, Stefanos D., et al. (författare)
  • Mapping Grain Strains in Sand Under Load Using Neutron Diffraction Scanning
  • 2018
  • Ingår i: Micro to MACRO Mathematical Modelling in Soil Mechanics. - Cham : Springer International Publishing. - 2297-0215 .- 2297-024X. - 9783319994734 - 9783319994741 ; , s. 23-33
  • Bokkapitel (refereegranskat)abstract
    • Towards the improvement of the understanding of force/stress distribution in granular media under load, a new experimental approach is suggested. Neutron diffraction, a non-conventional experimental technique, has been successfully used to map the evolution of intragranular strains in sand specimens loaded in a novel plane-strain apparatus. Representative preliminary results from recent experiments are presented, focusing on the correlation between the macro- and micro-scale response of the material, to highlight the potential of the experimental approach.
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  • Resultat 1-10 av 74
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