| 1. |
- Engström, Gunnar, et al.
(författare)
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The Swedish CArdioPulmonary BioImage Study : objectives and design
- 2015
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Ingår i: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 278:6, s. 645-659
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Tidskriftsartikel (refereegranskat)abstract
- Cardiopulmonary diseases are major causes of death worldwide, but currently recommended strategies for diagnosis and prevention may be outdated because of recent changes in risk factor patterns. The Swedish CArdioPulmonarybioImage Study (SCAPIS) combines the use of new imaging technologies, advances in large-scale 'omics' and epidemiological analyses to extensively characterize a Swedish cohort of 30 000 men and women aged between 50 and 64 years. The information obtained will be used to improve risk prediction of cardiopulmonary diseases and optimize the ability to study disease mechanisms. A comprehensive pilot study in 1111 individuals, which was completed in 2012, demonstrated the feasibility and financial and ethical consequences of SCAPIS. Recruitment to the national, multicentre study has recently started.
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| 2. |
- Lindblad, Ida, et al.
(författare)
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Adolescents with type 1 diabetes mellitus and attention-deficit/hyperactivity disorder require specific support from healthcare professionals
- 2017
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Ingår i: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 106:12, s. 1994-1997
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Tidskriftsartikel (refereegranskat)abstract
- AIM: Managing type 1 diabetes mellitus requires efficient cognitive and executive skills, and adolescents who have attention-deficit/hyperactivity disorder (ADHD) may face specific challenges. This study explored young people's experiences of diabetes treatment and care.METHOD: In a population-based study, comprising 175 patients aged 5-16 years with type 1 diabetes mellitus in two Swedish counties, we found that eight also met criteria for ADHD. Six of these, aged 14.5-16 years, participated 2013-2014 in interviews that targeted aspects of their diabetes treatment. Conducted by two psychologists, these used the inductive qualitative, semi-structured interview format.RESULTS: The two boys and four girls all reported difficulties in creating routines for their diabetes treatment and that problems were aggravated during stress. They had been criticised by their parents and the diabetes team when their blood levels indicated inadequate diabetes control. They requested ongoing information, involvement of their friends, group meetings and easy access to the healthcare system during difficult times.CONCLUSION: Patients with type 1 diabetes mellitus and concomitant ADHD faced problems with their diabetes management, especially during stressful situations. Diabetes care provision should pay particular attention to patients with co-existing neuropsychiatric and neurodevelopmental disorders such as ADHD.
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| 3. |
- Engström, Lena, et al.
(författare)
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Organic winter oilseed rape response to N fertilisation and preceding agroecosystem
- 2014
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Ingår i: Field Crops Research. - : Elsevier BV. - 0378-4290 .- 1872-6852. ; 167, s. 94-101
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Tidskriftsartikel (refereegranskat)abstract
- Increased knowledge on how to use organic amendments will increase crop productivity in organic farming. The effect of autumn and spring application of organic fertilisers on the yield of organic winter oilseed rape (WOR) with various preceding crops was studied at eight organic farm sites in southern Sweden in 2008/2009 and 2009/2010, in a two-factor experiment. Autumn N fertilisation (F1) comprised Biofer, applied at 0 and 50 kg N ha(-1), and spring N fertilisation (F2) comprised increasing rates of Vinasse (0, 50, 100, 150, 200 kg N ha(-1)). How soil mineral N, N uptake in late autumn and early spring, plant-available soil N during spring and summer (soilN(plant)) and yield level was associated with economically optimum N fertilisation rate (OptN) in spring was investigated. Autumn N application (Biofer) only increased yield by 140-410 kg ha(-1) at three sites, when there was a risk of low plant-available soil N during spring and summer, due to dry weather conditions or N immobilisation in soil caused by residues of previous grass ley crops. Nitrogen fertilisation during autumn cannot be recommended due to the high levels of soil mineral N in late autumn and risk for N leaching. Spring N fertilisation (Vinasse) can be recommended when the preceding crop is a grass ley, as yield increases were the highest, 820-1400 kg ha(-1). Spring N fertilisation had no impact on yield and cannot be recommended when the preceding crop is pasture or clover, providing that N uptake during autumn is great and/or if N availability in soil during spring and summer is not likely to be limited by e.g. dry weather conditions and weeds. Regression analysis confirmed that plant-available soil N was associated with OptN rate in spring and showed that factors such as soil mineral N, N uptake in late autumn, SoilN(plant) and yield level must be considered when estimating spring N fertilisation. (C) 2014 Elsevier B.V. All rights reserved.
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| 4. |
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| 5. |
- Rönnstrand, Lars, et al.
(författare)
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SHP-2 binds to Tyr763 and Tyr1009 in the PDGF β-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis
- 1999
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Ingår i: Oncogene. - : Stockton Press. - 0950-9232. ; 18:25, s. 3696-3702
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Tidskriftsartikel (refereegranskat)abstract
- Activation of the beta-receptor for platelet-derived growth factor (PDGF) by its ligand leads to autophosphorylation on a number of tyrosine residues. Here we show that Tyr763 in the kinase insert region is a novel autophosphorylation site, which after phosphorylation binds the protein tyrosine phosphatase SHP-2. SHP-2 has also previously been shown to bind to phosphorylated Tyr1009 in the PDGF beta-receptor. Porcine aortic endothelial (PAE) cells transfected with a PDGF beta-receptor in which Tyr763 and Tyr1009 were mutated to phenylalanine residues failed to associate with SHP-2 after ligand stimulation. Moreover, PDGF-BB-induced Ras GTP-loading and Erk2 activation were severely compromised in the receptor mutant. Whereas the mitogenic response to PDGF-BB remained at the same level as in cells expressing wild-type PDGF beta-receptor, chemotaxis induced by PDGF-BB was significantly decreased in the case of the Y763F/Y1009F mutant cells, suggesting an important role for SHP-2 in chemotactic signaling.
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| 6. |
- Stenberg, Maria, et al.
(författare)
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Nitrogen management strategies in organic winter oilseed rape (Brassica napus L.) production
- 2013
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Ingår i: Organic Agriculture. - : Springer Science and Business Media LLC. - 1879-4238 .- 1879-4246. ; 3, s. 71-82
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Tidskriftsartikel (refereegranskat)abstract
- The efficiency of four different organic fertilisers applied to winter oilseed rape, before (early) or at the beginning of regrowth in spring (normal application time), was studied in two row spacing systems of 12 and 48 cm with inter row hoeing to provide strategies to optimise spring nitrogen (N) fertilisation to organic winter oilseed rape. Six annual field experiments were performed during 2005-2008 in south central Sweden. The following amendments, i.e., Vinass from yeast production, Biofer meat and bone meal, dairy slurry and chicken manure, were applied at a rate corresponding to 100 kgN ha-1. CropN uptake, seed yield and oil content indicated greater and earlier N availability of Vinass after application compared with the other amendments. Yield increased by 1,300 kg ha-1 at early spring application (27 March) of Vinass and by 700 kg ha-1 when applied at normal application time (18-26 April). The yield increase was 400 kg ha-1 regardless of application time of Biofer, chicken manure and dairy slurry. The substantially greater yield increase in the Vinass application in relation to the other fertilisers demonstrated the yield potential when N is available earlier. The smaller effect on the yield by the other organic amendments indicated that the N release was not synchronised with the crop demand, and available too late during crop development to affect yield or less N was available due to N losses. Consequently, only Vinass can be recommended for spring application. The two row spacing systems tested can both be recommended, since yield levels were similar.
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