| 1. |
- Hedbrant, Alexander, Ph.D, 1987-, et al.
(författare)
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Occupational quartz and particle exposure affect systemic levels of inflammatory markers related to inflammasome activation and cardiovascular disease
- 2023
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Ingår i: Environmental Health. - : BioMed Central (BMC). - 1476-069X. ; 22:1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The inflammatory responses are central components of diseases associated with particulate matter (PM) exposure, including systemic diseases such as cardiovascular diseases (CVDs). The aim of this study was to determine if exposure to PM, including respirable dust or quartz in the iron foundry environment mediates systemic inflammatory responses, focusing on the NLRP3 inflammasome and novel or established inflammatory markers of CVDs.METHODS: The exposure to PM, including respirable dust, metals and quartz were determined in 40 foundry workers at two separate occasions per worker. In addition, blood samples were collected both pre-shift and post-shift and quantified for inflammatory markers. The respirable dust and quartz exposures were correlated to levels of inflammatory markers in blood using Pearson, Kendall τ and mixed model statistics. Analyzed inflammatory markers included: 1) general markers of inflammation, including interleukins, chemokines, acute phase proteins, and white blood cell counts, 2) novel or established inflammatory markers of CVD, such as growth/differentiation factor-15 (GDF-15), CD40 ligand, soluble suppressor of tumorigenesis 2 (sST2), intercellular/vascular adhesion molecule-1 (ICAM-1, VCAM-1), and myeloperoxidase (MPO), and 3) NLRP3 inflammasome-related markers, including interleukin (IL)-1β, IL-18, IL-1 receptor antagonist (IL-1Ra), and caspase-1 activity.RESULTS: The average respirator adjusted exposure level to respirable dust and quartz for the 40 foundry workers included in the study was 0.65 and 0.020 mg/m3, respectively. Respirable quartz exposure correlated with several NLRP3 inflammasome-related markers, including plasma levels of IL-1β and IL-18, and several caspase-1 activity measures in monocytes, demonstrating a reverse relationship. Respirable dust exposure mainly correlated with non-inflammasome related markers like CXCL8 and sST2. CONCLUSIONS: The finding that NLRP3 inflammasome-related markers correlated with PM and quartz exposure suggest that this potent inflammatory cellular mechanism indeed is affected even at current exposure levels in Swedish iron foundries. The results highlight concerns regarding the safety of current exposure limits to respirable dust and quartz, and encourage continuous efforts to reduce exposure in dust and quartz exposed industries.
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| 2. |
- Abola, Benard, et al.
(författare)
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A Variant of Updating Page Rank in Evolving Tree graphs
- 2019
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Ingår i: Proceedings of 18th Applied Stochastic Models and Data Analysis International Conference with the Demographics 2019 Workshop, Florence, Italy: 11-14 June, 2019. - : ISAST: International Society for the Advancement of Science and Technology. - 9786185180331 ; , s. 31-49
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Konferensbidrag (refereegranskat)abstract
- PageRank update refers to the process of computing new PageRank values after change(s) (addition or removal of links/vertices) has occurred in real life networks. The purpose of the updating is to avoid recalculating the values from scratch. To efficiently carry out the update, we consider PageRank as the expected number of visits to target vertex if multiple random walks are performed, starting at each vertex once and weighing each of these walks by a weight value. Hence, it might be looked at as updating non-normalised PageRank. In the proposed approach, a scaled adjacency matrix is sequentially updated after every change and the levels of the vertices being updated as well. This enables sets of internal and sink vertices dependent on their roots or parents, thus vector-vector product can be performed sequentially since there are no infinite steps from one vertex to the other.
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| 3. |
- Abola, Benard, et al.
(författare)
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A Variant of Updating PageRank in Evolving Tree Graphs
- 2021
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Ingår i: Applied Modeling Techniques and Data Analysis 1. - : John Wiley & Sons, Inc. Hoboken, NJ, USA. - 9781786306739 - 9781119821564 ; , s. 3-22
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Bokkapitel (refereegranskat)abstract
- A PageRank update refers to the process of computing new PageRank valuesafter a change(s) (addition or removal of links/vertices) has occurred in real-lifenetworks. The purpose of updating is to avoid re-calculating the values from scratch.To efficiently carry out the update, we consider PageRank to be the expected numberof visits to a target vertex if multiple random walks are performed, starting at eachvertex once and weighing each of these walks by a weight value. Hence, it mightbe looked at as updating a non-normalized PageRank. We focus on networks of treegraphs and propose an approach to sequentially update a scaled adjacency matrix afterevery change, as well as the levels of the vertices. In this way, we can update thePageRank of affected vertices by their corresponding levels.
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| 4. |
- Abola, Benard, et al.
(författare)
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Chapter 2. Nonlinearly Perturbed Markov Chains and Information Networks
- 2021
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Ingår i: Applied Modeling Techniques and Data Analysis 1. - Hoboken, NJ : John Wiley & Sons. - 9781786306739 - 9781119821564 ; , s. 23-55
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Bokkapitel (refereegranskat)abstract
- This chapter is devoted to studies of perturbed Markov chains, commonly used for the description of information networks. In such models, the matrix of transition probabilities for the corresponding Markov chain is usually regularized by adding aspecial damping matrix, multiplied by a small damping (perturbation) parameter ε. In this chapter, we present the results of detailed perturbation analysis of Markov chains with damping component and numerical experiments supporting and illustrating the results of this perturbation analysis.
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| 5. |
- Abola, Benard, 1971-, et al.
(författare)
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Evaluation of Stopping Criteria for Ranks in Solving Linear Systems
- 2019. - Chapter 10
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Ingår i: Data Analysis and Applications 1: Clustering and Regression, Modeling‐estimating, Forecasting and Data Mining, Volume 2. - Hoboken, NJ, USA : John Wiley & Sons. - 9781119597568 - 9781786303820 ; , s. 137-152
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Bokkapitel (refereegranskat)abstract
- Bioinformatics, internet search engines (web pages) and social networks are some of the examples with large and high sparsity matrices. For some of these systems, only the actual ranks of the solution vector is interesting rather than the vector itself. In this case, it is desirable that the stopping criterion reflects the error in ranks rather than the residual vector that might have a lower convergence. This chapter evaluates stopping criteria on Jacobi, successive over relaxation (SOR) and power series iterative schemes. Numerical experiments were performed and results show that Kendall's correlation coefficient gives good stopping criterion of ranks for linear system of equations. The chapter focuses on the termination criterion as means of obtaining good ranks. It outlines some studies carried out on stopping criteria in solving the linear system.
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| 6. |
- Abola, Benard, 1971-, et al.
(författare)
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PageRank in evolving tree graphs
- 2018
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Ingår i: Stochastic Processes and Applications. - Cham : Springer. - 9783030028244 ; , s. 375-390
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Bokkapitel (refereegranskat)abstract
- In this article, we study how PageRank can be updated in an evolving tree graph. We are interested in finding how ranks of the graph can be updated simultaneously and effectively using previous ranks without resorting to iterative methods such as the Jacobi or Power method. We demonstrate and discuss how PageRank can be updated when a leaf is added to a tree, at least one leaf is added to a vertex with at least one outgoing edge, an edge added to vertices at the same level and forward edge is added in a tree graph. The results of this paper provide new insights and applications of standard partitioning of vertices of the graph into levels using breadth-first search algorithm. Then, one determines PageRanks as the expected numbers of random walk starting from any vertex in the graph. We noted that time complexity of the proposed method is linear, which is quite good. Also, it is important to point out that the types of vertex play essential role in updating of PageRank.
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| 7. |
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| 8. |
- Abola, Benard
(författare)
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Perturbed Markov Chains with Damping Component and Information Networks
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis brings together three thematic topics, PageRank of evolving tree graphs, stopping criteria for ranks and perturbed Markov chains with damping component. The commonality in these topics is their focus on ranking problems in information networks. In the fields of science and engineering, information networks are interesting from both practical and theoretical perspectives. The fascinating property of networks is their applicability in analysing broad spectrum of problems and well established mathematical objects. One of the most common algorithms in networks' analysis is PageRank. It was developed for web pages’ ranking and now serves as a tool for identifying important vertices as well as studying characteristics of real-world systems in several areas of applications. Despite numerous successes of the algorithm in real life, the analysis of information networks is still challenging. Specifically, when the system experiences changes in vertices /edges or it is not strongly connected or when a damping stochastic matrix and a damping factor are added to an information matrix. For these reasons, extending existing or developing methods to understand such complex networks is necessary.Chapter 2 of this thesis focuses on information networks with no bidirectional interaction. They are commonly encountered in ecological systems, number theory and security systems. We consider certain specific changes in a network and describe how the corresponding information matrix can be updated as well as PageRank scores. Specifically, we consider the graph partitioned into levels of vertices and describe how PageRank is updated as the network evolves.In Chapter 3, we review different stopping criteria used in solving a linear system of equations and investigate each stopping criterion against some classical iterative methods. Also, we explore whether clustering algorithms may be used as stopping criteria.Chapter 4 focuses on perturbed Markov chains commonly used for the description of information networks. In such models, the transition matrix of an information Markov chain is usually regularised and approximated by a stochastic (Google type) matrix. Stationary distribution of the stochastic matrix is equivalent to PageRank, which is very important for ranking of vertices in information networks. Determining stationary probabilities and related characteristics of singularly perturbed Markov chains is complicated; leave alone the choice of regularisation parameter. We use the procedure of artificial regeneration for the perturbed Markov chain with the matrix of transition probabilities and coupling methods. We obtain ergodic theorems, in the form of asymptotic relations. We also derive explicit upper bounds for the rate of convergence in ergodic relations. Finally, we illustrate these results with numerical examples.
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| 9. |
- Abola, Benard, 1971-, et al.
(författare)
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Updating of PageRank in Evolving Tree graphs
- 2020
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Ingår i: Data Analysis and Applications 3. - : John Wiley & Sons. - 9781786305343 - 9781119721871 ; , s. 35-51
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Bokkapitel (refereegranskat)abstract
- Summary Updating PageRank refers to a process of computing new PageRank values after changes have occurred in a graph. The main goal of the updating is to avoid recalculating the values from scratch. This chapter focuses on updating PageRank of an evolving tree graph when a vertex and an edge are added sequentially. It describes how to maintain level structures when a cycle is created and investigates the practical and theoretical efficiency to update PageRanks for an evolving graph with many cycles. The chapter discusses the convergence of the power method applied to stochastic complement of Google matrix when a feedback vertex set is used. It also demonstrates that the partition by feedback vertex set improves asymptotic convergence of power method in updating PageRank in a network with cyclic components.
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| 10. |
- Albuhayri, Mohammed, et al.
(författare)
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An Improved Asymptotics of Implied Volatility in the Gatheral Model
- 2022
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Ingår i: <em>Springer Proceedings in Mathematics and Statistics</em>. - Cham : Springer Nature. - 9783031178191 - 9783031178207 ; , s. 3-13
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Konferensbidrag (refereegranskat)abstract
- We study the double-mean-reverting model by Gatheral. Our previous results concerning the asymptotic expansion of the implied volatility of a European call option, are improved up to order 3, that is, the error of the approximation is ultimately smaller that the 1.5th power of time to maturity plus the cube of the absolute value of the difference between the logarithmic security price and the logarithmic strike price.
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