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- Axelsson, Kjell, et al.
(författare)
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Intraarticular administration of ketorolac, morphine, and ropivacaine combined with intraarticular patient-controlled regional analgesia for pain relief after shoulder surgery : a randomized, double-blind study
- 2008
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Ingår i: Anesthesia and Analgesia. - : Lippincott Williams & Wilkins. - 0003-2999 .- 1526-7598. ; 106:1, s. 328-333
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: In this study we assessed the efficacy of intraarticular regional analgesia on postoperative pain and analgesic requirements. METHODS: Fifty-one patients undergoing shoulder surgery (Bankart) were recruited into this double-blind study. At the end of the operation, patients were randomized to three groups to receive intraarticularly via a catheter: Group 1: ropivacaine 90 mg (9 mL), morphine 4 mg (10 mL), and ketorolac 30 mg (1 mL) (total volume 20 mL); Groups 2 and 3: saline (20 mL). In addition, Groups 1 and 3 received 1 mL saline IV while Group 2 received ketorolac 30 mg (1 mL) IV. Postoperatively, Group 1 received pain relief using 10 mL 0.5% ropivacaine on demand via the intraarticular catheter while Groups 2 and 3 received 10 mL of saline intraarticularly. Group 3 was the Control group. RESULTS: Postoperative pain at rest and on movement were lower in Group 1 than in Groups 2 and 3 during the first 30 and 120 min, respectively. The time to first request for local anesthetic infusion was longer in Group 1 than in Groups 2 and 3 (P < 0.001). The median morphine consumption during the first 24 postoperative hours was less in Groups 1 and 2 than in Group 3 (P < 0.001). There was no significant difference in analgesic consumption between Group 1 and Group 2. The median satisfaction score was higher in Group 1 compared with Groups 2 (P < 0.05) and 3 (P < 0.001). CONCLUSIONS: A combination of intraarticular ropivacaine, morphine, and ketorolac followed by intermittent injections of ropivacaine as needed provided better pain relief, less morphine consumption, and improved patient satisfaction compared with the control group. The group that received IV ketorolac consumed less morphine and was more satisfied with treatment than patients in the control group.
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| 4. |
- Osman, Abdimajid, et al.
(författare)
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Main haplotypes and mutational analysis of vitamin K epoxide reductase (VKORC1) in a Swedish population : A retrospective analysis of case records
- 2006
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Ingår i: Journal of Thrombosis and Haemostasis. - : Elsevier BV. - 1538-7933 .- 1538-7836. ; 4:8, s. 1723-1729
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Tidskriftsartikel (refereegranskat)abstract
- Background: Vitamin K epoxide reductase (VKORC1) is the site of inhibition by coumarins. Several reports have shown that mutations in the gene encoding VKORC1 affect the sensitivity of the enzyme for warfarin. Recently, three main haplotypes of VKORC1; *2, *3 and *4 have been observed, that explain most of the genetic variability in warfarin dose among Caucasians. Objectives: We have investigated the main haplotypes of the VKORC1 gene in a Swedish population. Additional objective was to screen the studied population for mutations in the coding region of VKORC1 gene. Patients/methods: Warfarin doses and plasma S- and R-warfarin of 98 patients [with a target International Normalized Ratio (INR) of 2.0–3.0] have been correlated to VKORC1 haplotypes. Controls of 180 healthy individuals have also been haplotyped. Furthermore, a retrospective analysis of case records was performed to find any evidence indicating influence of VKORC1 haplotypes on warfarin response in the first 4 weeks (initiation phase) and the latest 12 months of warfarin treatment. Results and conclusions: Our result shows that VKORC1*2 is the most important haplotype for warfarin dosage. Patients with VKORC1*2 haplotype had more frequent visits than patients with VKORC1*3 or *4 haplotypes, higher coefficient of variation (CV) of prothrombin time-INR and higher percentage of INR values outside the therapeutic interval (i.e. 2.0–3.0) than patients with VKORC1*3 or *4 haplotypes. Also, there was a statistically significant difference in warfarin dose (P < 0.001) and R-warfarin plasma levels (P < 0.01) between VKORC1*2 and VKORC1*3 or 4 haplotypes. Patients with VKORC1*2 haplotype seem to require much lower warfarin doses than other patients.
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| 6. |
- Volodina, Elena, 1973, et al.
(författare)
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SweLL on the rise: Swedish Learner Language corpus for European Reference Level studies.
- 2016
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Ingår i: Proceedings of the Tenth International Conference on Language Resources and Evaluation (LREC 2016), May 23-28, 2016, Portorož, Slovenia. - Paris : European Language Resources Association. - 9782951740891
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Konferensbidrag (refereegranskat)abstract
- We present a new resource for Swedish, SweLL, a corpus of Swedish Learner essays linked to learners’ performance according to the Common European Framework of Reference (CEFR). SweLL consists of three subcorpora – SpIn, SW1203 and Tisus, collected from three different educational establishments. The common metadata for all subcorpora includes age, gender, native languages, time of residence in Sweden, type of written task. Depending on the subcorpus, learner texts may contain additional information, such as text genres, topics, grades. Five of the six CEFR levels are represented in the corpus: A1, A2, B1, B2 and C1 comprising in total 339 essays. C2 level is not included since courses at C2 level are not offered. The work flow consists of collection of essays and permits, essay digitization and registration, meta-data annotation, automatic linguistic annotation. Inter-rater agreement is presented on the basis of SW1203 subcorpus. The work on SweLL is still ongoing with more that 100 essays waiting in the pipeline. This article both describes the resource and the “how-to” behind the compilation of SweLL.
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