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1.	Dias, Mariana Castro, et al. (author) Claudin-3-deficient C57BL/6J mice display intact brain barriers 2019 In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9 Journal article (peer-reviewed)abstract The tight junction protein claudin-3 has been identified as a transcriptional target of the Wnt/beta-catenin signaling pathway regulating blood-brain barrier (BBB) maturation. In neurological disorders loss of claudin-3 immunostaining is observed at the compromised BBB and blood-cerebrospinal fluid barrier (BCSFB). Although these observations support a central role of claudin-3 in regulating brain barriers' tight junction integrity, expression of claudin-3 at the brain barriers has remained a matter of debate. This prompted us to establish claudin-3-/-C57BL/6J mice to study the role of claudin-3 in brain barrier integrity in health and neuroinflammation. Bulk and single cell RNA sequencing and direct comparative qRT-PCR analysis of brain microvascular samples from WT and claudin-3-/- mice show beyond doubt that brain endothelial cells do not express claudin-3 mRNA. Detection of claudin-3 protein at the BBB in vivo and in vitro is rather due to junctional reactivity of anti-claudin-3 antibodies to an unknown antigen still detected in claudin-3-/- brain endothelium. We confirm expression and junctional localization of claudin-3 at the BCSFB of the choroid plexus. Our study clarifies that claudin-3 is not expressed at the BBB and shows that absence of claudin-3 does not impair brain barrier function during health and neuroinflammation in C57BL/6J mice.
2.	Dias, Mariana, et al. (author) Claudin 3-Deficient C57BL/6 Mice Display Intact Brain Barriers 2017 In: Journal of Vascular Research. - : KARGER. - 1018-1172 .- 1423-0135. ; 54, s. 63-63 Journal article (other academic/artistic)

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Type of publication: journal article (2)

Type of content: other academic/artistic (1); peer-reviewed (1)

Author/Editor: Betsholtz, Christer (2); Coisne, Caroline (2); Lazarevic, Ivana (2); Baden, Pascale (2); Bruggmann, Remy (2); Lyck, Ruth (2); show more...; Enzmann, Gaby (2); Deutsch, Urban (2); Furuse, Mikio (2); Engelhardt, Britta (2); He, Liqun (1); Vanlandewijck, Micha ... (1); Dias, Mariana Castro (1); Hata, Masaki (1); Iwamoto, Noriko (1); Francisco, David Mig ... (1); Baier, Felix A. (1); Stroka, Deborah (1); Tsukita, Shoichiro (1); Dias, Mariana (1); Francisco, David (1); show less...

University: Uppsala University (2); Karolinska Institutet (2)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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