| 1. |
- Lindskog, Sven, et al.
(författare)
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Validation of an Algorithm for Chronic Periodontitis Risk Assessment and Prognostication : Analysis of an Inflammatory Reactivity Test and Selected Risk Predictors
- 2010
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Ingår i: Journal of Periodontology. - : American Academy of Periodontology. - 0022-3492 .- 1943-3670. ; 81:6, s. 837-847
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Tidskriftsartikel (refereegranskat)abstract
- Background: Patients with severe forms of chronic periodontitis present with varying degrees of decreased inflammatory reactivity. A previously reported algorithm for chronic periodontitis risk assessment and prognostication is based on the analysis of some 20 risk predictors. One of these predictors is a skin provocation test that assesses the individual patient's reactivity to a lipid A challenge. The aim of this report was to analyze results from validation data for the algorithm with respect to the contribution of results of the skin provocation test as a risk predictor for the progression of chronic periodontitis and to compare these results with the contribution from other predictors, namely smoking, angular bony destruction, furcation involvement, abutment teeth, and endodontic pathology. Methods: Data from a previously reported clinical validation sample were used for the analysis, including the calculation of quality measures and explanatory values using different types of regression analysis and non-parametric testing. Results: Smoking, endodontic pathology, abutment teeth, angular bony destruction, and furcation involvement presented with individual explanatory values for periodontitis progression between 4% and 13% and highly significant parameter estimates. Explanatory values for the results of the skin provocation test ranged between 2.6% and 5.1% depending on the disease severity group, with a positive predictive value of 82% for the identification of high-risk patients. Conclusion: The skin provocation test provided a clinically significant contribution to the quality of analysis with the periodontitis risk and prognostication algorithm, in particular in the selection of high-risk patients for in-depth individual tooth analysis.
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| 2. |
- Lindskog, Sven, et al.
(författare)
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Validation of an Algorithm for Chronic Periodontitis Risk Assessment and Prognostication: Risk Predictors, Explanatory Values, Measures of Quality, and Clinical Use
- 2010
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Ingår i: JOURNAL OF PERIODONTOLOGY. - : American Academy of Periodontology. - 0022-3492 .- 1943-3670. ; 81:4, s. 584-593
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Tidskriftsartikel (refereegranskat)abstract
- Background: The American Academy of Periodontology has recently stated that, "[risk assessment will become] increasingly important in periodontal treatment planning and should be part of every comprehensive dental and periodontal evaluation." (J Periodontol 2006;77:1608). Unaided risk assessment and prognostication show significant variability because chronic periodontitis is a multifactorial disease. This report summarizes the clinical validation of an algorithm for chronic periodontitis risk assessment and prognostication. The algorithm is a Web-based analytic tool that integrates some 20 risk predictors and calculates scores indicating levels of risk for chronic periodontitis for the dentition (Level I) and, if an elevated risk is found, prognosticates disease progression tooth by tooth (Level II). Methods: An independent clinical validation sample was generated in an open, prospective clinical trial and analyzed in a predetermined validation plan. Results: The analyses identified two threshold scores above which significant progression of periodontitis was found. Based on these scores, sufficiently high explanatory values with significant and increasing parameter estimates for increasing risk were established in Level I, justifying detailed analysis tooth by tooth in Level II. Subsequent prognostication of chronic periodontitis in Level II was found to be accompanied by clinically relevant measures of quality in relation to rates of disease progression. Three score intervals representing increasing levels of periodontitis progression were identified corresponding to increasing levels of significant annual marginal bone loss. Conclusions: The predictors included in the algorithm reflect a relevant selection for periodontitis risk assessment. Risk assessment and prognostication with the algorithm provides the clinician with a validated, reliable, consistent, and objective tool supporting treatment planning.
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| 3. |
- Ohlsson, H, et al.
(författare)
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Understanding adherence to official guidelines on statin prescribing in primary health care-a multi-level methodological approach.
- 2005
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Ingår i: European Journal of Clinical Pharmacology. - : Springer Science and Business Media LLC. - 1432-1041 .- 0031-6970. ; 61:Aug 25, s. 657-665
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim was to investigate the role that municipalities and out-patient health care centres (HCCs) have in understanding adherence to official guidelines on statin prescribing. Our hypothesis was that after guideline publication, adherence to recommended statin prescription would increase and variance among HCCs and municipalities would decrease. Since multi-level regression analysis (MLRA) is a relatively new methodology in pharmacoepidemiology, we also aimed to explore the application of MLRA in our investigation. Methods: We obtained data from the Swedish Corporation of Pharmacies record of sales regarding all initial prescriptions of statins issued between April and December 2003. We applied multi-level analysis on 34,514 individual prescriptions (level 1) nested within 226 HCCs (level 2), which in turn were nested within 33 municipalities (level 3). Temporal trends and gender differences were investigated by means of random slope analysis. Variance was expressed using median odds ratio (MOR) and interval odds ratio. Results: HCCs appeared to be more relevant than municipalities for understanding the physicians' propensity to prescribe a recommended statin (MORHCC=1.96 and MORMunicipality=1.41). Overall prevalence of adherence was very low (about 20%). After publication of the guidelines, prescription of recommended statins increased, and variance among HCCs decreased but only during the first 4 months of the observation period. Conclusion: The publication of official guidelines in the county of Scania exerted a positive influence on statin prescription but, at the end of the observation period, adherence was still low and practice variation high. These facts may reflect inefficient therapeutic traditions and suggest that more intensive interventions may be necessary to promote rational statin prescription.
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| 4. |
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| 5. |
- Schallmeiner, Edith, et al.
(författare)
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Sensitive protein detection via triple-binder proximity ligation assays
- 2007
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Ingår i: Nature Methods. - : Springer Science and Business Media LLC. - 1548-7091 .- 1548-7105. ; 4:2, s. 135-137
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Tidskriftsartikel (refereegranskat)abstract
- The detection of weakly expressed proteins and protein complexes in biological samples represents a fundamental challenge. We have developed a new proximity-ligation strategy named 3PLA that uses three recognition events for the highly specific and sensitive detection of as little as a hundred molecules of the vascular endothelial growth factor (VEGF), the biomarkers troponin I, and prostate-specific antigen (PSA) alone or in complex with an inhibitor--demonstrating the versatility of 3PLA.
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| 6. |
- Abrahamsson, Ingemar, et al.
(författare)
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Försurningssituationen i rinnande vatten: Västra Götaland
- 2002
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna rapport behandlar försurningsläget i Västra Götalands rinnande vatten baserat på en vattenkemisk undersökning av 220 vattendrag hösten 2001. Syftet är att beskriva dagens situation och diskutera den närmaste framtiden i förhållande till det nationella miljömålet att högst 15% av sträckan rinnande vatten skall vara drabbad av antropogen (onaturlig) försurning år 2010. Rapporten skall dessutom utgöra ett underlag för regionala anpassningar och preciseringar av miljömålet samt ligga till grund för åtgärdsstrategiska överväganden.
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| 7. |
- Alehagen, Urban, et al.
(författare)
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Are There Any Significant Differences Between Females and Males in the Management of Heart Failure? Gender Aspects of an Elderly Population With Symptoms Associated With Heart Failure
- 2009
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Ingår i: JOURNAL OF CARDIAC FAILURE. - : Elsevier BV. - 1071-9164. ; 15:6, s. 501-507
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Tidskriftsartikel (refereegranskat)abstract
- Background: An increasing interest has been shown in potential l., 11 With heart failure (HF), a serious condition for the individual. To evaluate whether there are any differences ill the prevalence of HF, cardiac function, biomarkers. and the treatment of HF with respect to gender. Methods and Results: All persons ages 70 to 80 in a rural municipality were invited to participate ill the project 876 persons accepted. Three cardiologists evaluated the patients including a new history, clinical examination. electrocardiogram, chest x-ray. blood samples. and Doppler echocardiography to assess both Systolic and diastolic function. The patients were followed during a mean period of 8 years. Conclusion: Females hypertension more frequently and included fewer smokers than their male Counterparts. A Female preponderance was seen in those with preserved systolic function. whereas males predominated among those with systolic dysfunction. During the follow-up period, 20% of the males and 14% of the females died of cardiovascular diseases. The results did not show any inferior treatment of females with HF. but it clearly was more difficult to correctly classify female patients presenting with symptoms of HE
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| 8. |
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| 9. |
- Augustinsson, Sören, 1957-, et al.
(författare)
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Is it possible to design for sustainable work systems? : exploring the conjunction between regenerative work and complexity
- 2008
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this paper is to explore the social challenge of sustainable work systems and regenerative work. This is done by using complexity theory to grasp and understand the vision of sustainable work systems. A comprehensive literature review generated a theoretical framework for both sustainable work systems and understanding of complexity and in addition these two phenomena’s point of contact. Two case studies provide an empirical example and illustrate the potential in the conjunction of sustainability and complexity.A sustainable work system can be described as a simultaneous development and convergence between different levels and interests interrelated to the work organisation; from the individual perspective to the surrounding world of the organisation. A sustainable work system is characterised by having the capacity to regenerate and support the growth of the individual’s (employees) cognitive and emotional resources and at the same time maintain or increase competitiveness of the organisation. From the employee’s perspective this paper suggests that in order to reinforce and strengthen the individual, these same resources must be both recognised, adopted and have satisfactory support in the work organisation.This paper suggests that work organisations ought to create a work environment condition that supports self organisation, and acknowledge complexity and uncertainty as the normal state of reality.
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| 10. |
- Augustinsson, Sören, et al.
(författare)
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Is it possible to design for sustainable work systems? : exploring the conjunction between regenerative work and complexity
- 2008
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this paper is to explore the social challenge of sustainable work systems and regenerative work. This is done by using complexity theory to grasp and understand the vision of sustainable work systems. A comprehensive literature review generated a theoretical framework for both sustainable work systems and understanding of complexity and in addition these two phenomena’s point of contact. Two case studies provide an empirical example and illustrate the potential in the conjunction of sustainability and complexity.A sustainable work system can be described as a simultaneous development and convergence between different levels and interests interrelated to the work organisation; from the individual perspective to the surrounding world of the organisation. A sustainable work system is characterised by having the capacity to regenerate and support the growth of the individual’s (employees) cognitive and emotional resources and at the same time maintain or increase competitiveness of the organisation. From the employee’s perspective this paper suggests that in order to reinforce and strengthen the individual, these same resources must be both recognised, adopted and have satisfactory support in the work organisation.This paper suggests that work organisations ought to create a work environment condition that supports self organisation, and acknowledge complexity and uncertainty as the normal state of reality.
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