| 1. |
- Björk, Göran, 1956, et al.
(författare)
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Flow of Canadian Basin Deep Water in the Western Eurasian Basin of the Arctic Ocean
- 2010
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Ingår i: Deep Sea Research. - : Elsevier BV. - 0967-0637 .- 1879-0119. ; 57:4, s. 577-586
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Tidskriftsartikel (refereegranskat)abstract
- The LOMROG 2007 expedition targeted the previously unexplored southern part of the Lomonosov Ridge north of Greenland together with a section from the Morris Jesup Rise to Gakkel Ridge. The oceanographic data shows that Canadian Basin Deep Water (CBDW) passes the Lomonosov Ridge in the area of the Intra Basin close to the North Pole and then continues along the ridge towards Greenland and further along its northernmost continental slope. The CBDW is clearly evident as a salinity maximum and oxygen minimum at a depth of about 2000 m. The cross slope sections at the Amundsen Basin side of the Lomonosov Ridge and further south at the Morris Jesup Rise show a sharp frontal structure higher up in the water column between Makarov Basin water and Amundsen Basin water. The frontal structure continues upward into the Atlantic Water up to a depth of about 300 m. The observed water mass division at levels well above the ridge crest indicates a strong topographic steering of the flow and that different water masses tend to pass the ridge guided by ridge-crossing isobaths at local topographic heights and depressions. A rough scaling analysis shows that the extremely steep and sharply turning bathymetry of the Morris Jesup Rise may force the boundary current to separate and generate deep eddies.
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| 2. |
- Carvajal, Gisela, 1983, et al.
(författare)
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Correlation between Synthetic Aperture Radar Surface Winds and Deep Water Velocity in the Amundsen Sea, Antarctica
- 2013
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Ingår i: Remote Sensing. - : MDPI AG. - 2072-4292. ; 5:8, s. 4088-4106
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Tidskriftsartikel (refereegranskat)abstract
- The recent observed thinning of the glacier ice shelves in the Amundsen Sea (Antarctica) has been attributed to warm deep currents, possibly induced by along-coast winds in the vicinity of the glacial ice sheet. Here, high resolution maps of wind fields derived from Synthetic Aperture Radar (SAR) data have been studied and correlated with subsurface measurements of the deep water velocities in the Amundsen Sea area. Focus is on periods with low ice coverage in 2010 and 2011. In 2010, which had comparatively low ice coverage, the results indicate a more rapid response to wind forcing in the deep currents than in 2011. The SAR wind speed maps have better spatial resolution than available reanalysis data, and higher maximum correlation was obtained with SAR data than with reanalysis data despite the lower temporal resolution. The maximum correlation was R = 0.71, in a direction that is consistent with wind-driven Ekman theory. This is significantly larger than in previous studies. The larger correlation could be due to the better spatial resolution or the restriction to months with minimum ice coverage. The results indicate that SAR is a useful complement to infer the subsurface variability of the ocean circulation in remote areas in polar oceans.
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| 3. |
- Ried, Janina S., et al.
(författare)
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A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
- 2016
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.
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| 4. |
- Shungin, Dmitry, et al.
(författare)
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New genetic loci link adipose and insulin biology to body fat distribution.
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 187-378
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Tidskriftsartikel (refereegranskat)abstract
- Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
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| 7. |
- Abel, Edvard, 1970, et al.
(författare)
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Impact on quality of life of IMRT versus 3-D conformal radiation therapy in head and neck cancer patients: A case control study
- 2017
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Ingår i: Advances in Radiation Oncology. - : Elsevier BV. - 2452-1094. ; 2:3, s. 346-353
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Tidskriftsartikel (refereegranskat)abstract
- Objective The purpose of this study was to prospectively and longitudinally compare the health-related quality of life (HRQOL) outcomes between head and neck (HN) cancer patients treated with parotid-sparing intensity modulated radiation therapy (IMRT) and patients treated with 3-dimensional conventional radiation therapy (3D-CRT). Methods and materials Before and up to 12 months after treatment, HRQOL was recorded in patients with HN cancer who were referred to the Department of Oncology at Sahlgrenska University Hospital for curative IMRT. The study group's HRQOL was compared with a matched group of patients from previous descriptive HRQOL studies treated with 3D-CRT. Both groups' HRQOL was measured by the European Organization for Research and Treatment for Cancer QLQ-C30 and European Organization for Research and Treatment for Cancer QLQ-HN35 at 6 time points in the first year after diagnosis. Results Two hundred and seven patients were included, 111 treated with IMRT and 96 matched controls treated with 3D-CRT. Both groups' HRQOL deteriorated during and after treatment. Just after treatment, worse HRQOL scores were observed in the IMRT group regarding insomnia (38 vs 27; P = .032), appetite loss (64 vs 50; P = .019), senses (54 vs 41; P = .017), and coughing (39 vs 26, P = .009). At 12 months, however, significantly better HRQOL scores were observed in the IMRT group regarding problems with dry mouth (72 vs 62; P = .018), pain (28 vs 20; P = .018), sexuality (37 vs 23; P = .016), social contacts (10 vs 6; P = .026), cognitive functioning (79 vs 87; P = .0057), and financial difficulties (12 vs 20; P = .0019). Conclusions This study further supports the hypothesis that the introduction of IMRT has improved the long-term quality of life of HN cancer patients who have been treated with radiation therapy, but might cause more acute side effects. Longer follow-up is needed to study late complications.
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| 8. |
- Aldenhoff, Wiebke, 1985, et al.
(författare)
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Comparison of ice/water classification in Fram Strait from C- and L-band SAR imagery
- 2018
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Ingår i: Annals of Glaciology. - : Cambridge University Press (CUP). - 0260-3055 .- 1727-5644. ; 59:76pt2, s. 112-123
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Tidskriftsartikel (refereegranskat)abstract
- In this paper an algorithm for ice/water classification of C- and L-band dual polarization synthetic aperture radar data is presented. A comparison of the two different frequencies is made in order to investigate the potential to improve classification results with multi-frequency data. The algorithm is based on backscatter intensities in co- and cross-polarization and autocorrelation as a texture feature. The mapping between image features and ice/water classification is made with a neural network. Accurate ice/water maps for both frequencies are produced by the algorithm and the results of two frequencies generally agree very well. Differences are found in the marginal ice zone, where the time difference between acquisitions causes motion of the ice pack. C-band reliably reproduces the outline of the ice edge, while L-band has its strengths for thin ice/calm water areas within the icepack. The classification shows good agreement with ice/water maps derived from met.no ice-charts and radiometer data from AMSR-2. Variations are found in the marginal ice zone where the generalization of the ice charts and lower accuracy of ice concentration from radiometer data introduce deviations. Usage of high-resolution dual frequency data could be beneficial for improving ice cover information for navigation and modelling.
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| 9. |
- Aldenhoff, Wiebke, 1985, et al.
(författare)
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COMPARISON OF SENTINEL-1 SAR AND SENTINEL-3 ALTIMETRY DATA FOR SEA ICE TYPE DISCRIMINATION
- 2019
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Ingår i: IGARSS 2019 - 2019 IEEE International Geoscience and Remote Sensing Symposium. - 9781538691540
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In this paper near co-incidental Sentinel-1 C-band SAR imagery and Sentinel-3 SRAL Ku-band altimeter data are compared for their capabilities of sea ice type discrimination. Knowledge of sea ice type is important for climate research and safety in Arctic offshore operations. First-year ice is characterised by a low SAR backscatter intensity in both HH and HV polarisation compared to multi-year ice, while the altimeter waveform parameters show high pulse peakiness and peak power compared to multi-year ice. Thus SAR imagery and altimetry can principally discriminate different ice types. The complexity of the backscattered radar signal however impedes a clear separation of the two types for all cases. Cross comparison of the two sensors offers an opportunity of high resolution validation data, which is often lacking for sea ice studies.
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| 10. |
- Aldenhoff, Wiebke, 1985, et al.
(författare)
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First-Year and Multiyear Sea Ice Incidence Angle Normalization of Dual-Polarized Sentinel-1 SAR Images in the Beaufort Sea
- 2020
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Ingår i: IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing. - 1939-1404 .- 2151-1535. ; 13, s. 1540-1550
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Tidskriftsartikel (refereegranskat)abstract
- Automatic and visual sea ice classification of SAR imagery is impeded by the incidence angle dependence of backscatter intensities. Knowledge of the angular dependence of different ice types is therefore necessary to account for this effect. While consistent estimates exist for HH polarization for different ice types, they are lacking HV polarization data, especially for multiyear sea ice. Here we investigate the incidence angle dependence of smooth and rough/deformed first-year and multiyear ice of different ages for wintertime dual-polarization Sentinel-1 C-band SAR imagery in the Beaufort Sea. Assuming a linear relationship, this dependence is determined using the difference in incidence angle and backscatter intensities from ascending and descending images of the same area. At cross-polarization rough/deformed first-year sea ice shows the strongest angular dependence with -text{0.11} dB/1{circ } followed by multiyear sea ice with -text{0.07} dB/text{1}{circ }, and old multiyear ice (older than three years) with -text{0.04} dB/text{1}{circ }. The noise floor is found to have a strong impact on smooth first-year ice and estimated slopes are therefore not fully reliable. At co-polarization, we obtained slope values of -0.24, -0.20, -text{0.15}, and -text{0.10} dB/text{1}{circ } for smooth first-year, rough/deformed first-year, multiyear, and old multiyear sea ice, respectively. Furthermore, we show that imperfect noise correction of the first subswath influences the obtained slopes for multiyear sea ice. We demonstrate that incidence angle normalization should not only be applied to co-polarization but should also be considered for cross-polarization images to minimize intra ice type variation in backscatter intensity throughout the entire image swath. © 2008-2012 IEEE.
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