↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Träfflista för sökning "WFRF:(Eriksson Olof) "

Search: WFRF:(Eriksson Olof)

Result 1-10 of 785

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Eriksson, Olof, et al. (author) Quantitative Imaging of Serotonergic Biosynthesis and Degradation in the Endocrine Pancreas 2014 In: Journal of Nuclear Medicine. - : Society of Nuclear Medicine. - 0161-5505 .- 1535-5667 .- 2159-662X. ; 55:3, s. 460-465 Journal article (peer-reviewed)abstract Serotonergic biosynthesis in the endocrine pancreas, of which the islets of Langerhans is the major constituent, has been implicated in insulin release and β cell proliferation. In this study, we investigated the feasibility of quantitative noninvasive imaging of the serotonergic metabolism in the pancreas using the PET tracer (11)C-5-hydroxy-l-tryptophan ((11)C-5-HTP).METHODS: Uptake of (11)C-5-HTP, and its specificity for key enzymes in the serotonergic metabolic pathway, was assessed in vitro (INS-1 and PANC1 cells and human islet and exocrine preparations) and in vivo (nonhuman primates and healthy and diabetic rats).RESULTS: In vitro tracer uptake in endocrine cells (INS-1 and human islets), but not PANC1 and exocrine cells, was mediated specifically by intracellular conversion into serotonin. Pancreatic uptake of (11)C-5-HTP in nonhuman primates was markedly decreased by inhibition of the enzyme dopa decarboxylase, which converts (11)C-5-HTP to (11)C-serotonin and increased after inhibition of monoamine oxidase-A, the main enzyme responsible for serotonin degradation. Uptake in the rat pancreas was similarly modulated by inhibition of monoamine oxidase-A and was reduced in animals with induced diabetes.CONCLUSION: The PET tracer (11)C-5-HTP can be used for quantitative imaging of the serotonergic system in the endocrine pancreas.
2.	Eriksson, Olof, et al. (author) The Positron Emission Tomography ligand [11C]5-Hydroxy-Tryptophan can be used as a surrogate marker for the human endocrine pancreas 2014 In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 63:10, s. 3428-3437 Journal article (peer-reviewed)abstract In humans a well-developed serotonin system is localized to the pancreatic islets while being absent in exocrine pancreas. Assessment of pancreatic serotonin biosynthesis could therefore be used to estimate the human endocrine pancreas. Proof of concept was tested in a prospective clinical trial by comparisons of type 1 diabetic (T1D) patients, with extensive reduction of beta cells, with healthy volunteers (HV).C-peptide negative (i.e. insulin-deficient) T1D subjects (n=10) and HV (n=9) underwent dynamic Positron Emission Tomography with the radiolabeled serotonin precursor [(11)C]5-Hydroxy-Tryptophan ([(11)C]5-HTP).A significant accumulation of [(11)C]5-HTP was obtained in the pancreas of the HV, with large inter-individual variation. A substantial and highly significant reduction (66%) in the pancreatic uptake of [(11)C]5-HTP in T1D subjects was observed, and this was most evident in the corpus and caudal regions of the pancreas where beta-cells normally are the major constituent of the islets.[(11)C]5-HTP retention in the pancreas was reduced in T1D compared to non-diabetic subjects. Accumulation of [(11)C]5-HTP in the pancreas of both HV and subjects with T1D were in agreement with previously reported morphological observations on the beta cell volume implying that [(11)C]5-HTP retention is a useful non-invasive surrogate marker for the human endocrine pancreas.
3.	Aad, G., et al. (author) 2012 In: Nuclear Physics, Section B. - : Elsevier BV. - 0550-3213 .- 1873-1562. ; 864:3, s. 341-381 Journal article (peer-reviewed)
4.	Aad, G., et al. (author) 2013 Journal article (peer-reviewed)
5.	Aad, G., et al. (author) A search for high-mass resonances decaying to tau(+)tau(-) in pp collisions at root s=8 TeV with the ATLAS detector 2015 In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :7 Journal article (peer-reviewed)
6.	Aad, G., et al. (author) A search for prompt lepton-jets in pp collisions at root s=7 TeV with the ATLAS detector 2013 Journal article (peer-reviewed)
7.	Aad, G., et al. (author) ATLAS measurements of the properties of jets for boosted particle searches 2012 In: Physical Review D (Particles, Fields, Gravitation and Cosmology). - 1550-2368 .- 1550-7998. ; 86:7 Journal article (peer-reviewed)
8.	Aad, G., et al. (author) Combined search for the Standard Model Higgs boson in pp collisions at root s=7 TeV with the ATLAS detector 2012 In: Physical Review D (Particles, Fields, Gravitation and Cosmology). - 1550-2368 .- 1550-7998. ; 86:3 Journal article (peer-reviewed)
9.	Aad, G, et al. (author) Evidence for Electroweak Production of W^{±}W^{±}jj in pp Collisions at sqrt[s]=8 TeV with the ATLAS Detector. 2014 In: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 113:14 Journal article (peer-reviewed)
10.	Aad, G., et al. (author) Evidence for the associated production of a W boson and a top quark in ATLAS at root s=7 TeV 2012 Journal article (peer-reviewed)

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-10 of 785

Refine your search

Type of publication: journal article (542); conference paper (101); other publication (31); doctoral thesis (23); reports (21); book chapter (17); show more...; research review (14); book (12); review (9); editorial proceedings (8); licentiate thesis (4); editorial collection (2); artistic work (1); show less...

Type of content: peer-reviewed (574); other academic/artistic (189); pop. science, debate, etc. (20)

Author/Editor: Aad, G (139); Zwalinski, L. (135); Ekelöf, Tord (133); Abdinov, O (127); Abbott, B. (126); Aleksa, M. (126); show more...; Aielli, G. (125); Albrand, S. (125); Aleksandrov, I. N. (125); Alexander, G. (125); Arabidze, G. (125); Carli, T. (125); Davidek, T. (125); Farbin, A. (125); Ellert, Mattias (124); Ferrari, Arnaud (124); Abi, B. (124); Abramowicz, H. (124); Adams, D. L. (124); Adelman, J. (124); Adye, T. (124); Albert, J. (124); Alexopoulos, T. (124); Amako, K. (124); Anderson, K. J. (124); Anghinolfi, F. (124); Asquith, L. (124); Baker, O. K. (124); Beck, H. P. (124); Binet, S. (124); Boonekamp, M. (124); Bosman, M. (124); Busato, E. (124); Calvet, D. (124); Catinaccio, A. (124); Cavasinni, V. (124); Chakraborty, D. (124); Chekanov, S. (124); Chen, H. (124); Chen, X. (124); Cinca, D. (124); Constantinescu, S. (124); Cornelissen, T. (124); Del Prete, T. (124); Di Ciaccio, L. (124); Di Girolamo, B. (124); Dolgoshein, B. A. (124); Dunford, M. (124); Errede, S. (124); Etienvre, A. I. (124); show less...

University: Uppsala University (392); Lund University (172); Royal Institute of Technology (162); Stockholm University (161); University of Gothenburg (101); Linnaeus University (98); show more...; Umeå University (94); Karolinska Institutet (72); Chalmers University of Technology (64); Linköping University (47); Örebro University (28); Swedish University of Agricultural Sciences (16); Mid Sweden University (14); University of Gävle (13); Luleå University of Technology (10); Halmstad University (4); Jönköping University (4); RISE (2); VTI - The Swedish National Road and Transport Research Institute (2); Swedish National Heritage Board (1); Blekinge Institute of Technology (1); Marie Cederschiöld högskola (1); Swedish Agency for Marine and Water Management (1); show less...

Language: English (648); Swedish (72); French (59); Undefined language (4); Danish (1); Latin (1)

Research subject (UKÄ/SCB): Natural sciences (285); Medical and Health Sciences (234); Humanities (105); Engineering and Technology (57); Social Sciences (46); Agricultural Sciences (11)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view