| 1. |
- Zhou, XP, et al.
(författare)
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Non-coding variability at the APOE locus contributes to the Alzheimer's risk
- 2019
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 3310-
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Tidskriftsartikel (refereegranskat)abstract
- Alzheimer’s disease (AD) is a leading cause of mortality in the elderly. While the coding change of APOE-ε4 is a key risk factor for late-onset AD and has been believed to be the only risk factor in the APOE locus, it does not fully explain the risk effect conferred by the locus. Here, we report the identification of AD causal variants in PVRL2 and APOC1 regions in proximity to APOE and define common risk haplotypes independent of APOE-ε4 coding change. These risk haplotypes are associated with changes of AD-related endophenotypes including cognitive performance, and altered expression of APOE and its nearby genes in the human brain and blood. High-throughput genome-wide chromosome conformation capture analysis further supports the roles of these risk haplotypes in modulating chromatin states and gene expression in the brain. Our findings provide compelling evidence for additional risk factors in the APOE locus that contribute to AD pathogenesis.
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| 2. |
- Morriën, Elly, et al.
(författare)
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Soil networks become more connected and take up more carbon as nature restoration progresses
- 2017
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- Soil organisms have an important role in aboveground community dynamics and ecosystem functioning in terrestrial ecosystems. However, most studies have considered soil biota as a black box or focussed on specific groups, whereas little is known about entire soil networks. Here we show that during the course of nature restoration on abandoned arable land a compositional shift in soil biota, preceded by tightening of the belowground networks, corresponds with enhanced efficiency of carbon uptake. In mid- and long-term abandoned field soil, carbon uptake by fungi increases without an increase in fungal biomass or shift in bacterial-to-fungal ratio. The implication of our findings is that during nature restoration the efficiency of nutrient cycling and carbon uptake can increase by a shift in fungal composition and/or fungal activity. Therefore, we propose that relationships between soil food web structure and carbon cycling in soils need to be reconsidered.
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| 3. |
- Faber, Jack H., et al.
(författare)
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Stocktaking for Agricultural Soil Quality and Ecosystem Services Indicators and their Reference Values : EJP SOIL Internal Project SIREN Deliverable 2
- 2022
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The SIREN project has made an inventory of indicator systems for assessing soil quality and ecosystem services derived from agricultural soils, as currently used by Member States associated in the EJP SOIL program and beyond. The project aimed to identify and review the national approaches to make use of soil data in the assessment of soil-related ecosystem services, and has surveyed the knowledge gaps and needs for development hindering policy implementation as experienced in the 20 countries participating in the SIREN consortium. A comprehensive conceptual framework linking soil quality to ecosystem services has been collated from earlier proposals in the scientific literature, unifying various concepts associated with soil quality and ecosystem services, and providing a glossary of consistent terminology. SIREN has also taken stock of evaluation criteria for indicators of soil quality as implemented in national soil monitoring schemes. Based on reviews of literature, international policy, international stakeholder views, wide application in national soil monitoring and application in EU projects contributing to agricultural soil quality assessment, a synthesis was produced of policy-relevant soil quality indicators with high potential for harmonised application in national and European monitoring. A tiered approach is proposed for implementation of such a minimum dataset.
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| 4. |
- Pascual, Unai, et al.
(författare)
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On the value of soil biodiversity and ecosystem services
- 2015
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Ingår i: Ecosystem Services. - : Elsevier BV. - 2212-0416. ; 15, s. 11-18
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Tidskriftsartikel (refereegranskat)abstract
- This paper provides a framework to understand the source of the economic value of soil biodiversity and soil ecosystem services and maps out the pathways of such values. We clarify the link between components of the economic value of soil biodiversity and their associated services of particular relevance to soils. We contend that soil biodiversity and associated ecosystem services give rise to two main additive value components in the context of risk and uncertainty: an output value and an insurance value. These are illustrated with examples from soil ecology and a simple heuristic model. The paper also points towards the challenges of capturing such values highlighting the differences between private (individual) and public (global) sources of value. (C) 2015 Elsevier B.V. All rights reserved.
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