| 1. |
- Arroyo-Torres, B., et al.
(författare)
-
VLTI/AMBER Studies of the Atmospheric Structure and Fundamental Parameters of Red Giant and Supergiant Stars
- 2015
-
Ingår i: WHY GALAXIES CARE ABOUT AGB STARS III. - : ASTRONOMICAL SOC PACIFIC. - 9781583818794 ; , s. 91-96
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- We present recent near-IR interferometric studies of red giant and super giant stars, which are aimed at obtaining information on the structure of the atmospheric layers and constraining the fundamental parameters of these objects. The observed visibilities of six red supergiants (RSGs), and also of one of the five red giants observed, indicate large extensions of the molecular layers, as previously observed for Mira stars. These extensions are not predicted by hydrostatic PHOENIX model atmospheres, hydrodynamical (RED) simulations of stellar convection, or self-excited pulsation models. All these models based on parameters of RSGs lead to atmospheric structures that are too compact compared to our observations. We discuss how alternative processes might explain the atmospheric extensions for these objects. As the continuum appears to be largely free of contamination by molecular layers, we can estimate reliable Rosseland angular radii for our stars. Together with distances and bolometric fluxes, we estimate the effective temperatures and luminosities of our targets, locate them in the HR diagram, and compare their positions to recent evolutionary tracks.
|
|
| 2. |
- Arroyo-Torres, B., et al.
(författare)
-
VLTI/AMBER studies of the atmospheric structure and fundamental parameters of red giant and supergiant stars
- 2015
-
Ingår i: Why Galaxies Care about AGB Stars III: A Closer Look in Space and Time. Proceedings of ASP Conference Series. - 9781583818794 ; 497, s. 91-96
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- We present recent near-IR interferometric studies of red giant and supergiant stars, which are aimed at obtaining information on the structure of the atmospheric layers and at constraining the fundamental parameters of these objects. The observed visibilities of the red supergiants (RSGs) and also of one red giant indicate large extensions of the molecular layers, as those previously observed for Mira stars. These extensions are not predicted by hydrostatic PHOENIX model atmospheres, hydrodynamical (RHD) simulations of stellar convection, or self-excited pulsation models. All these models based on parameters of RSGs lead to atmospheric structures that are too compact compared to our observations. We discuss how alternative processes might explain the atmospheric extensions for these objects. As the continuum appears to be largely free of contamination by molecular layers, we can estimate reliable angular Rosseland radii of our stars. Together with distances and bolometric fluxes, we estimate the effective temperatures and luminosities of our targets, locate them in the HR diagram, and compare their positions to recent evolutionary tracks.
|
|
| 3. |
- Arroyo-Torres, B., et al.
(författare)
-
VLTI/AMBER observations of cold giant stars: atmospheric structures and fundamental parameters
- 2014
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 566
-
Tidskriftsartikel (refereegranskat)abstract
- Aims. The main goal of this research is to determine the angular size and the atmospheric structures of cool giant stars (epsilon Oct, beta Peg, NU Pav, psi Peg, and gamma Hya) and to compare them with hydrostatic stellar model atmospheres, to estimate the fundamental parameters, and to obtain a better understanding of the circumstellar environment. Methods. We conducted spectro-interferometric observations of epsilon Oct, beta Peg, NU Pav, and psi Peg in the near-infrared K band (2.13-2.47 mu m), and gamma Hya (1.9-2.47 mu m) with the VLTI/AMBER instrument at medium spectral resolution (similar to 1500). To obtain the fundamental parameters, we compared our data with hydrostatic atmosphere models (PHOENIX). Results. We estimated the Rosseland angular diameters of epsilon Oct, beta Peg, NU Pav, psi Peg, and gamma Hya to be 11.66 +/- 1.50 mas, 16.87 +/- 1.00 mas, 13.03 +/- 1.75 mas, 6.31 +/- 0.35 mas, and 3.78 +/- 0.65 mas, respectively. Together with distances and bolometric fluxes (obtained from the literature), we estimated radii, effective temperatures, and luminosities of our targets. In the beta Peg visibility, we observed a molecular layer of CO with a size similar to that modeled with PHOENIX. However, there is an additional slope in absorption starting around 2.3 m. This slope is possibly due to a shell of H2O that is not modeled with PHOENIX (the size of the layer increases to about 5% with respect to the near-continuum level). The visibility of psi Peg shows a low increase in the CO bands, compatible with the modeling of the PHOENIX model. The visibility data of epsilon Oct, NU Pav, and gamma Hya show no increase in molecular bands. Conclusions. The spectra and visibilities predicted by the PHOENIX atmospheres agree with the spectra and the visibilities observed in our stars (except for beta Peg). This indicates that the opacity of the molecular bands is adequately included in the model, and the atmospheres of our targets have an extension similar to the modeled atmospheres. The atmosphere of beta Peg is more extended than that predicted by the model. The role of pulsations, if relevant in other cases and unmodeled by PHOENIX, therefore seems negligible for the atmospheric structures of our sample. The targets are located close to the red limits of the evolutionary tracks of the STAREVOL model, corresponding to masses between 1 M-circle dot and 3 M-circle dot. The STAREVOL model fits the position of our stars in the Hertzsprung-Russell (HR) diagram better than the Ekstrom model does. STAREVOL includes thermohaline mixing, unlike the Ekstrom model, and complements the latter for intermediate-mass stars.
|
|
| 4. |
|
|
| 5. |
- Moreno-Càceres, J, et al.
(författare)
-
Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17
- 2014
-
Ingår i: Cell Death and Disease. - : Springer Science and Business Media LLC. - 2041-4889 .- 2041-4889. ; 5
-
Tidskriftsartikel (refereegranskat)abstract
- Transforming growth factor-beta (TGF-β) plays a dual role in hepatocytes, inducing both pro- and anti-apoptotic responses, whose balance decides cell fate. Survival signals are mediated by the epidermal growth factor receptor (EGFR) pathway, which is activated by TGF-β in these cells. Caveolin-1 (Cav1) is a structural protein of caveolae linked to TGF-β receptors trafficking and signaling. Previous results have indicated that in hepatocytes, Cav1 is required for TGF-β-induced anti-apoptotic signals, but the molecular mechanism is not fully understood yet. In this work, we show that immortalized Cav1(-/-) hepatocytes were more sensitive to the pro-apoptotic effects induced by TGF-β, showing a higher activation of caspase-3, higher decrease in cell viability and prolonged increase through time of intracellular reactive oxygen species (ROS). These results were coincident with attenuation of TGF-β-induced survival signals in Cav1(-/-) hepatocytes, such as AKT and ERK1/2 phosphorylation and NFκ-B activation. Transactivation of the EGFR pathway by TGF-β was impaired in Cav1(-/-) hepatocytes, which correlated with lack of activation of TACE/ADAM17, the metalloprotease responsible for the shedding of EGFR ligands. Reconstitution of Cav1 in Cav1(-/-) hepatocytes rescued wild-type phenotype features, both in terms of EGFR transactivation and TACE/ADAM17 activation. TACE/ADAM17 was localized in detergent-resistant membrane (DRM) fractions in Cav1(+/+) cells, which was not the case in Cav1(-/-) cells. Disorganization of lipid rafts after treatment with cholesterol-binding agents caused loss of TACE/ADAM17 activation after TGF-β treatment. In conclusion, in hepatocytes, Cav1 is required for TGF-β-mediated activation of the metalloprotease TACE/ADAM17 that is responsible for shedding of EGFR ligands and activation of the EGFR pathway, which counteracts the TGF-β pro-apoptotic effects. Therefore, Cav1 contributes to the pro-tumorigenic effects of TGF-β in liver cancer cells.
|
|
| 6. |
|
|
| 7. |
- Ardura-Fabregat, A., et al.
(författare)
-
Targeting Neuroinflammation to Treat Alzheimer’s Disease
- 2017
-
Ingår i: CNS Drugs. - : Springer Science and Business Media LLC. - 1172-7047 .- 1179-1934. ; 31:12, s. 1-26
-
Forskningsöversikt (refereegranskat)abstract
- Over the past few decades, research on Alzheimer’s disease (AD) has focused on pathomechanisms linked to two of the major pathological hallmarks of extracellular deposition of beta-amyloid peptides and intra-neuronal formation of neurofibrils. Recently, a third disease component, the neuroinflammatory reaction mediated by cerebral innate immune cells, has entered the spotlight, prompted by findings from genetic, pre-clinical, and clinical studies. Various proteins that arise during neurodegeneration, including beta-amyloid, tau, heat shock proteins, and chromogranin, among others, act as danger-associated molecular patterns, that—upon engagement of pattern recognition receptors—induce inflammatory signaling pathways and ultimately lead to the production and release of immune mediators. These may have beneficial effects but ultimately compromise neuronal function and cause cell death. The current review, assembled by participants of the Chiclana Summer School on Neuroinflammation 2016, provides an overview of our current understanding of AD-related immune processes. We describe the principal cellular and molecular players in inflammation as they pertain to AD, examine modifying factors, and discuss potential future therapeutic targets.
|
|
| 8. |
- Fabregat-Santiago, F., et al.
(författare)
-
Influence of electrolyte in transport and recombination in dye-sensitized solar cells studied by impedance spectroscopy
- 2005
-
Ingår i: Solar Energy Materials and Solar Cells. - : Elsevier BV. - 0927-0248 .- 1879-3398. ; 87:04-jan, s. 117-131
-
Tidskriftsartikel (refereegranskat)abstract
- The main features of the characteristic impedance spectra of dye-sensitized solar cells are described in a wide range of potential conditions: from open to short circuit. An equivalent circuit model has been proposed to describe the parameters of electron transport, recombination, accumulation and other interfacial effects separately. These parameters were determined in the presence of three different electrolytes, both in the dark and under illumination. Shift in the conduction band edge due to the electrolyte composition was monitored in terms of the changes in transport resistance and charge accumulation in TiO2. The interpretation of the current-potential curve characteristics, fill factor, open-circuit photopotential and efficiency in the different conditions, was correlated with this shift and the features of the recombination resistance.
|
|
| 9. |
|
|
| 10. |
- Solano Donado, F., et al.
(författare)
-
Self-protection: a novel protection scheme for all-optical packet switching networks
- 2009
-
Ingår i: [Host publication title missing].
-
Konferensbidrag (refereegranskat)abstract
- All-optical packet switching designs have evolved in the last years. However, all-optical packet forwarding functionalities are still limited. Several label assignation methods have been studied in order to efficiently use the small label space of the designs. In this paper, we present a novel scheme for label switched path protection for networks with small label spaces, such as all-optical packet switching technologies based on all-optical label swapping. With the purpose of using as fewest labels as possible, the scheme has as basis using the same working paths as backup paths. The scheme is named self-protection. Properties and requirements of the schemes in mention are given in this paper. A brief analysis of the trade-off of the scheme is also provided.
|
|
