| 1. |
- Wang, HC, et al.
(författare)
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HMG-1 as a late mediator of endotoxin lethality in mice
- 1999
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 285:5425, s. 248-251
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Tidskriftsartikel (refereegranskat)abstract
- Endotoxin, a constituent of Gram-negative bacteria, stimulates macrophages to release large quantities of tumor necrosis factor (TNF) and interleukin-1 (IL-1), which can precipitate tissue injury and lethal shock (endotoxemia). Antagonists of TNF and IL-1 have shown limited efficacy in clinical trials, possibly because these cytokines are early mediators in pathogenesis. Here a potential late mediator of lethality is identified and characterized in a mouse model. High mobility group–1 (HMG-1) protein was found to be released by cultured macrophages more than 8 hours after stimulation with endotoxin, TNF, or IL-1. Mice showed increased serum levels of HMG-1 from 8 to 32 hours after endotoxin exposure. Delayed administration of antibodies to HMG-1 attenuated endotoxin lethality in mice, and administration of HMG-1 itself was lethal. Septic patients who succumbed to infection had increased serum HMG-1 levels, suggesting that this protein warrants investigation as a therapeutic target.
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| 2. |
- Franckié, M., et al.
(författare)
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Two-well quantum cascade laser optimization by non-equilibrium Green's function modelling
- 2018
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Ingår i: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 112:2
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Tidskriftsartikel (refereegranskat)abstract
- We present a two-quantum well THz intersubband laser operating up to 192 K. The structure has been optimized using non-equilibrium Green's function model. The result of this optimization was confirmed experimentally by growing, processing, and measuring a number of proposed designs. At high temperature (T > 200 K), the simulations indicate that lasing fails due to a combination of electron-electron scattering, thermal backfilling, and, most importantly, re-absorption coming from broadened states.
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| 3. |
- Hallett, Lauren M., et al.
(författare)
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Restoration ecology through the lens of
- 2023
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Ingår i: Trends in Ecology & Evolution. - : CELL PRESS. - 0169-5347 .- 1872-8383. ; 38:11, s. 1085-1096
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Forskningsöversikt (refereegranskat)abstract
- Advances in restoration ecology are needed to guide ecological restoration in a variable and changing world. Coexistence theory provides a framework for how variability in environmental conditions and species interactions affects species success. Here, we conceptually link coexistence theory and restoration ecology. First, including low-density growth rates (LDGRs), a classic metric of coexistence, can improve abundance-based restoration goals, because abundances are sensitive to initial treatments and ongoing variability. Second, growth-rate partitioning, developed to identify coexistence mechanisms, can improve restoration practice by informing site selection and indicating necessary interventions (e.g., site amelioration or competitor removal). Finally, coexistence methods can improve restoration assessment, because initial growth rates indicate trajectories, average growth rates measure success, and growth partitioning highlights interventions needed in future.
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| 4. |
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| 5. |
- Peretti, R., et al.
(författare)
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Room temperature operation of a deep etched buried heterostructure photonic crystal quantum cascade laser
- 2016
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Ingår i: Laser & Photonics reviews. - : Wiley-VCH Verlagsgesellschaft. - 1863-8880 .- 1863-8899. ; 10:5, s. 843-848
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Tidskriftsartikel (refereegranskat)abstract
- High power single mode quantum cascade lasers with a narrow far field are important for several applications including surgery or military countermeasure. Existing technologies suffer from drawbacks such as operation temperature and scalability. In this paper we introduce a fabrication approach that potentially solves simultaneously these remaining limitations. We demonstrate and characterize deep etched, buried photonic crystal quantum cascade lasers emitting around a wavelength of 8.5 μm. The active region was dry etched before being regrown with semi-insulating Fe:InP. This fabrication strategy results in a refractive index contrast of 10% allowing good photonic mode control, and simultaneously provides good thermal extraction during operation. Single mode emission with narrow far field pattern and peak powers up to 0.88 W at 263 K were recorded from the facet of the photonic crystal laser, and lasing operation was maintained up to room temperature. The lasing modes emitted from square photonic crystal mesas with a side length of 550μm, were identified as slow Bloch photonic crystal modes by means of three-dimensional photonic simulations and measurements. (Figure presented.).
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| 6. |
- Wang, Z., et al.
(författare)
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Large area surface-emitting photonic crystal quantum cascade laser
- 2019
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Ingår i: Optics InfoBase Conference Papers. - : OSA - The Optical Society.
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Konferensbidrag (refereegranskat)abstract
- Quantum cascade lasers (QCLs) are the sources of choice for many laser-based applications in the mid-infrared region. Because of the unique 2D in-plane coupling mechanism, a photonic crystal (PhC)QCL [1] has superior advantages on mode selection, surface emission, and beam control. In this work, we present a large-area (1.5 mm × 1.5 mm) PhC-QCL operating under pulsed mode at room temperature (289 K). The surface-emitting peak power is as high as 1 W.
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