| 1. |
- Li, Zhaosheng, et al.
(författare)
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Evidence for the Photoionization Absorption Edge in a Photospheric Radius Expansion X-Ray Burst from GRS 1747-312 in Terzan 6
- 2018
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Ingår i: Astrophysical Journal. - : IOP PUBLISHING LTD. - 0004-637X .- 1538-4357. ; 866:1
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Tidskriftsartikel (refereegranskat)abstract
- Thermonuclear X-ray bursts on the surface of neutron stars (NSs) can enrich the photosphere with metals, which may imprint photoionization edges on the burst spectra. We report here the discovery of absorption edges in the spectra of the type I X-ray burst from the NS low-mass X-ray binary GRS 1747-312 in Terzan 6 during observations by the Rossi X-ray Timing Explorer. We find that the edge energy evolves from 9.45 +/- 0.51 to similar to 6 keV and then back to 9.44 +/- 0.40 keV during the photospheric radius expansion phase and remains at 8.06 +/- 0.66 keV in the cooling tail. The photoionization absorption edges of hydrogen-like Ni, Fe, or an Fe/Ni mixture and the bound-bound transitions of metals may be responsible for the observed spectral features. The ratio of the measured absorption edge energy in the cooling tail to the laboratory value of the hydrogen-like Ni(Fe) edge energy allows us to estimate the gravitational redshift factor 1 + z = 1.34 +/- 0.11(1 + z = 1.15 +/- 0.09). The evolution of the spectral parameters during the cooling tail are well described by metal-rich atmosphere models. The combined constraints on the NS mass and radius from the direct cooling method and the tidal deformability strongly suggest very high atmospheric abundance of the iron group elements and limit the distance to the source to 11 +/- 1 kpc.
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| 2. |
- Peterlongo, Paolo, et al.
(författare)
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FANCM c.5791C>T nonsense mutation (rs144567652) induces exon skipping, affects DNA repair activity and is a familial breast cancer risk factor.
- 2015
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 24:18, s. 5345-5355
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Tidskriftsartikel (refereegranskat)abstract
- Numerous genetic factors that influence breast cancer risk are known. However, approximately two-thirds of the overall familial risk remain unexplained. To determine whether some of the missing heritability is due to rare variants conferring high to moderate risk, we tested for an association between the c.5791C>T nonsense mutation (p.Arg1931*; rs144567652) in exon 22 of FANCM gene and breast cancer. An analysis of genotyping data from 8635 familial breast cancer cases and 6625 controls from different countries yielded an association between the c.5791C>T mutation and breast cancer risk [odds ratio (OR) = 3.93 (95% confidence interval (CI) = 1.28-12.11; P = 0.017)]. Moreover, we performed two meta-analyses of studies from countries with carriers in both cases and controls and of all available data. These analyses showed breast cancer associations with OR = 3.67 (95% CI = 1.04-12.87; P = 0.043) and OR = 3.33 (95% CI = 1.09-13.62; P = 0.032), respectively. Based on information theory-based prediction, we established that the mutation caused an out-of-frame deletion of exon 22, due to the creation of a binding site for the pre-mRNA processing protein hnRNP A1. Furthermore, genetic complementation analyses showed that the mutation influenced the DNA repair activity of the FANCM protein. In summary, we provide evidence for the first time showing that the common p.Arg1931* loss-of-function variant in FANCM is a risk factor for familial breast cancer.
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| 3. |
- Watts, Anna L., et al.
(författare)
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Dense matter with eXTP
- 2019
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Ingår i: Science China Physics, Mechanics & Astronomy. - : Science Press. - 1674-7348 .- 1869-1927. ; 62:2
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Forskningsöversikt (refereegranskat)abstract
- In this White Paper we present the potential of the Enhanced X-ray Timing and Polarimetry (eXTP) mission for determining the nature of dense matter; neutron star cores host an extreme density regime which cannot be replicated in a terrestrial laboratory. The tightest statistical constraints on the dense matter equation of state will come from pulse profile modelling of accretion-powered pulsars, burst oscillation sources, and rotation-powered pulsars. Additional constraints will derive from spin measurements, burst spectra, and properties of the accretion flows in the vicinity of the neutron star. Under development by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Sciences, the eXTP mission is expected to be launched in the mid 2020s.
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