| 1. |
- Berndt, Sonja I., et al.
(författare)
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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 501-U69
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Tidskriftsartikel (refereegranskat)abstract
- Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
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| 2. |
- Fall, Ellen, et al.
(författare)
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Kompetensutveckling med iPads : appkurs på Samhällsvetenskapliga fakultetens bibliotek vid Lunds universitet
- 2012
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- As part of a project at the Faculty of Social Sciences at Lund University the staff at the Social Sciences Faculty Library (Sambib) attended a course on iPads and apps. In order to improve the skills of the whole staff, all librarians took the course. The participants’ experiences and opinions were documented in the blog where the course information was published and everyone filled out questionnaires. The course ended with a joint discussion. The results were analyzed based on assumptions about what knowledge librarians need in the future and how to develop these skills. Theories of how to develop learning organizations and improve team learning have also been applied to the outcome. Evaluation results show that the course not only led to a greater awareness of tablets and apps, it also gave a general competence in terms of new technology. The fact that all librarians participated in the course lead to a stronger team spirit, both within the workplace and towards the faculty and the university as a whole.
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| 3. |
- Fall, Ellen, et al.
(författare)
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Tablets as Tools : added value through mobile learning? Projektrapport
- 2014
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Rapport (populärvet., debatt m.m.)abstract
- Projektet Tablets as Tools - added value through mobile learning? har bedrivits på Samhällsvetenskapliga fakulteten vid Lunds universitet i samarbete mellan Statsvetenskapliga institutionen och biblioteket. Syftet med projektet har varit att utforska nya pedagogiska möjligheter och utvidga samarbetet mellan lärare, bibliotekarier och IT-tekniker. Särskilt fokus har legat på att få ökad kunskap om användande av informationsresurser i mobila enheter och om hur ny teknik kan användas i campusbunden och nätbaserad utbildning.
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| 4. |
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| 5. |
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| 6. |
- Locke, Adam E, et al.
(författare)
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Genetic studies of body mass index yield new insights for obesity biology.
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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| 7. |
- Shungin, Dmitry, et al.
(författare)
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New genetic loci link adipose and insulin biology to body fat distribution.
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 187-378
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Tidskriftsartikel (refereegranskat)abstract
- Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
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| 8. |
- Stenson, Linnea, et al.
(författare)
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Användarstyrt förvärv: Slutrapport för PDA-projektet vid Lunds Universitets bibliotek
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Lunds Universitets bibliotek testade mellan oktober 2013 och juli 2014 förvärvsmodellen Patron Driven Acquisition (PDA) via e-boksaggregatorn EBL. Arbetet med testet sattes upp i projektform. I följande rapport beskrivs modellen, projektgruppens förberedelsearbete samt resultat av projektet.
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