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- Liu, Zhenchao, et al.
(författare)
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Guided Mode Induced Surface Phase Mutation for Enhanced SPR Biosensor with Dual-Parameters Interrogation
- 2023
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Ingår i: Advanced Materials Interfaces. - : Wiley. - 2196-7350. ; 10:34
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Tidskriftsartikel (refereegranskat)abstract
- Ongoing research on the sensitivity and integration of refractive index-based biosensors has resulted in significant advancements. Here, the study presents an enhanced surface plasmon resonance biosensor that integrates imaging technology and features dual-parameter interrogation (intensity and phase) with guided mode coupling. By depositing a silica-waveguide-layer on a metal-layer, two-mode coupling is established to generate a high Q resonance and induce a phase mutation. The sensing performance experiment demonstrated a phase sensing sensitivity of 1.1 × 105 degree RIU−1, Q-value of the resonant peak up to 314, and figure of merit of 300 RIU−1, superior to most standard plasmonic sensors. An in-line phase-polarization modulation scheme combined with imaging technology is proposed to extract the resonant phase carrying refractive index information. Additionally, a pair-prism module is designed to optimize the sensing system configuration. Meanwhile, dual-parameters interrogation including the intensity and phase are demonstrated, which offers potential for complementary and multi-sensing fusion applications. The intensity interrogation also shows a considerable sensitivity of 7.2 × 104 a.u. RIU−1. Furthermore, it is combined with microfluidic chip to detect of alpha-synuclein protein closely related to Parkinson's disease, and the limit of detection can reach 300 pg mL−1 level, which indicated a considerable potential for high-throughput diagnosis application.
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| 2. |
- Liu, Zhenchao, et al.
(författare)
-
Phase Interrogation Sensor Based on All-Dielectric BIC Metasurface
- 2023
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Ingår i: Nano Letters. - : American Chemical Society (ACS). - 1530-6984 .- 1530-6992. ; 23:22, s. 10441-10448
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Tidskriftsartikel (refereegranskat)abstract
- The low performance of sensors based on an all-dielectric metasurface limits their application compared to metallic counterparts. Here, for the first time, an all-dielectric BIC (bound states in the continuum) metasurface is employed for highly sensitive phase interrogation refractive index sensing. The proposed sensor is well analyzed, fabricated, and characterized. Experimentally, a high-performance BIC-based microfluidic sensing chip with a Q factor of 1200 is achieved by introducing symmetry breaking. A refractive index sensor with high figure of merit of 418 RIU-1 is demonstrated, which is beneficial to the phase interrogation. Notably, we measure a record phase interrogation sensitivity of 2.7 x 10(4) deg/RIU to the refractive index, thus enabling the all-dielectric BIC to rival the refractive index detection capabilities of metal-based sensors such as surface plasmon resonance. This scheme establishes a pivotal role of the all-dielectric metasurface in the field of ultrahigh sensitivity sensors and opens possibilities for trace detection in biochemical analysis and environment monitoring.
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