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Träfflista för sökning "WFRF:(Fernlund J.) "

Sökning: WFRF:(Fernlund J.)

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  • Arvidsson, M., et al. (författare)
  • Resistivity imaging as a tool for rock quarry planning
  • 2007
  • Ingår i: Near Surface 2007. - 9781629937960
  • Konferensbidrag (refereegranskat)abstract
    • In the aggregate industry the use of geophysical measuring is rare. The aim of this project is to investigate how geophysical instruments can be a tool in prospecting for rock quarries, and also how they can be a help in which direction they should expand in. To have control over the quality of the aggregates is important and therefore to know when the rock mass is changing is of interest for the production. Two quarries, with different properties, were investigated with different geophysical methods, of which only the result from the electrical measurement is presented here. The fracture frequency was measured as well for comparison. The depth to the bedrock is visible in the inverted resistivity sections for the two sites, and an estimation of the quantity of the till is possible to make. It is also shown that the fracture frequency affects the resistivity of the bulk mass. The results also show that the resistivity imaging is well suited for detecting anomalies in the rock mass, which might affect the production.
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  • Fernlund, H. K. G., et al. (författare)
  • Learning tactical human behavior through observation of human performance
  • 2006
  • Ingår i: IEEE transactions on systems, man and cybernetics. Part B. Cybernetics. - 1083-4419 .- 1941-0492. ; 36:1, s. 128-140
  • Tidskriftsartikel (refereegranskat)abstract
    • It is widely accepted that the difficulty and expense involved in acquiring the knowledge behind tactical behaviors has been one limiting factor in the development of simulated agents representing adversaries and teammates in military and game simulations. Several researchers have addressed this problem with varying degrees of success. The problem mostly lies in the fact that tactical knowledge is difficult to elicit and represent through interactive sessions between the model developer and the subject matter expert. This paper describes a novel approach that employs genetic programming in conjunction with context-based reasoning to evolve tactical agents based upon automatic observation of a human performing a mission on a simulator. In this paper, we describe the process used to carry out the learning. A prototype was built to demonstrate feasibility and it is described herein. The prototype was rigorously and extensively tested. The evolved agents exhibited good fidelity to the observed human performance, as well as the capacity to generalize from it.
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  • Henkel, Herbert, et al. (författare)
  • Avike bay - a 10 km diameter possible impact structure at the Bothnian Sea coast of central Sweden.
  • 2005
  • Ingår i: IMPACT TECTONICS. - Berlin/Heidelberg : Springer-Verlag. - 3540241817 ; , s. 323-340
  • Konferensbidrag (refereegranskat)abstract
    • Avike Bay is a 270 degrees degree wide near-circular, 114 in deep bay on the Swedish coast of the Bothnian Sea, northeast of Sundsvall. The structure has a diameter of about 10 km. It was classified as a probable impact structure because of its extraordinary circular topography in the overwiew of impact structures in Fennoscandia. Recent studies lend further support to this interpretation. The structure has a submarine central mound, which is elevated some 40 in above the adjacent sea floor. It has a very distinct tangential and radial on-shore fracture pattern as seen in the topographic map. Along the southwestern shore of the Bay, an enigmatic quartzite breccia of unknown age occurs as part of a larger outcrop of polymict breccia with clasts of crystalline rocks and quartzite of unknown age. In thin section, planar fractures can be observed in quartz and feldspar grains. A detailed investigation showed that in a few cases the quartz grains contained microdeformation features closely resembling PDFs.
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  • Henricsson, M., et al. (författare)
  • The frequency and severity of retinopathy are related to HbA(1c) values after, but not at, the diagnosis of NIDDM
  • 1998
  • Ingår i: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 244:2, s. 149-154
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives. To examine the relationship between previous glycaemic exposure and prevalence of retinopathy 8 years after diagnosis of diabetes in 58 islet cell antibodies (ICA)-negative noninsulin-dependent diabetes mellitus (NIDDM) patients and in a group of 14 ICA-positive 'NIDDM' and insulin-dependent diabetes mellitus (IDDM) patients. Design and methods. The Wisconsin retinopathy scale was used to assess the retinopathy which was graded into mild, moderate and severe nonproliferative diabetic retinopathy (NPDR), or proliferative retinopathy (PDR). The frequency and severity of retinopathy was related to HbA(1c) levels at diagnosis, and 3 and 5 years later. Results. Thirty of the 58 ICA-negative NIDDM patients (52%) but only 2 of the 14 ICA-positive 'NIDDM' or IDDM patients (14%) had mild-moderate- severe NPDR 8 years after diagnosis (P = 0.02). None had PDR. Retinopathy 8 years after diagnosis in NIDDM (= 58 ICA-negative patients) was correlated with the degree of glycaemiC control (HbA(1c) levels) at 3 and 5 years after diagnosis, but not to HbA(1c) levels at diagnosis. The relative risk for a higher average HbA(1c) (per percentage) at 3 and 5 years was 1.56 for any retinopathy vs. no retinopathy (95% confidence interval 1.1-2.2; P = 0.01) and 1.68 for moderate to severe NPDR in comparison with no DR and mild NPDR (95% confidence interval 1.0-2.8; P = 0.04). Conclusions. Retinopathy after 8 years of diabetes in NIDDM patients was associated with impaired glycaemic control during previous years but not with glycaemic control at baseline. Good glycaemic control may prevent retinopathy in patients with NIDDM.
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  • Hugosson, J, et al. (författare)
  • Population-based screening for prostate cancer by measuring free and total serum prostate-specific antigen in Sweden
  • 2003
  • Ingår i: BJU International. - : Wiley. - 1464-4096 .- 1464-410X. ; 92, s. 39-43
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives To report the initial results from Sweden of a large population-based randomized study of screening using prostate-specific antigen (PSA) to detect prostate cancer, as the efficacy of such screening to decrease prostate cancer mortality has not yet been proven. Methods From the population registry men aged 50-66 years were randomized to screening (9973) and to future controls (9973). Men randomized to screening were invited to have their serum measured for free PSA (fPSA) and total PSA (tPSA) in serum using the Prostatus(R) f/tPSA assay (Perkin-Elmer, Turku, Finland). Men with a tPSA of <3.0 ng/mL were not further investigated, while those with a tPSA of &GE;3.0 ng/mL were investigated with a digital rectal examination (DRE), transrectal ultrasonography (TRUS) and sextant biopsies. Results Of those invited, 60% accepted PSA testing and 11.3% had a tPSA of &GE;3.0 ng/mL. Altogether 145 cancers were detected (positive predictive value, PPV, 24%); none were stage M1, two were stage N+ and 10 stage T3-4. Most (59%) cancers were impalpable and 39% were both impalpable and invisible on TRUS. At biopsy, 7% were Gleason score 2-4, 71% 5-6, 19% 7 and 2% Gleason score 8-10. A threshold tPSA of &GE;4.0 ng/mL would have detected 109 cancers in 366 biopsied men (PPV 30%) while cancer detection would have been 14% higher with a PPV of 36% using a threshold tPSA of &GE;3.0 ng/mL combined with a f/tPSA threshold of &LE;18%. Conclusion PSA screening detects early-stage low-grade prostate cancer. Both the sensitivity and specificity can be increased by incorporating f/tPSA with a tPSA threshold of <4 ng/mL.
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9.
  • I. FERNLUND, EVA, et al. (författare)
  • MYBPC3 hypertrophic cardiomyopathy can be detected by using advanced ECG in children and young adults
  • 2016
  • Ingår i: Journal of Electrocardiology. - : Elsevier BV. - 0022-0736 .- 1532-8430. ; 49:3, s. 392-400
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction The conventional ECG is commonly used to screen for hypertrophic cardiomyopathy (HCM), but up to 25% of adults and possibly larger percentages of children with HCM have no distinctive abnormalities on the conventional ECG, whereas 5 to 15% of healthy young athletes do. Recently, a 5-min resting advanced 12-lead ECG test ("A-ECG score") showed superiority to pooled criteria from the strictly conventional ECG in correctly identifying adult HCM. The purpose of this study was to evaluate whether in children and young adults, A-ECG scoring could detect echocardiographic HCM associated with the MYBPC3 genetic mutation with greater sensitivity than conventional ECG criteria and distinguish healthy young controls and athletes from persons with MYBPC3 HCM with greater specificity. Methods Five-minute 12-lead ECGs were obtained from 15 young patients (mean age 13.2 years, range 0-30 years) with MYBPC3 mutation and phenotypic HCM. The conventional and A-ECG results of these patients were compared to those of 198 healthy children and young adults (mean age 13.2, range 1 month-30 years) with unremarkable echocardiograms, and to those of 36 young endurance-trained athletes, 20 of whom had athletic (physiologic) left ventricular hypertrophy. Results Compared with commonly used, age-specific pooled criteria from the conventional ECG, a retrospectively generated A-ECG score incorporating results from just 2 derived vectorcardiographic parameters (spatial QRS-T angle and the change in the vectorcardiographic QRS azimuth angle from the second to the third eighth of the QRS interval) increased the sensitivity of ECG for identifying MYBPC3 HCM from 46% to 87% (p <0.05). Use of the same score also demonstrated superior specificity in a set of 198 healthy controls (94% vs. 87% for conventional ECG criteria; p <0.01) including in a subset of 36 healthy, young endurance-trained athletes (100% vs. 69% for conventional ECG criteria, p <0.001). Conclusions In children and young adults, a 2-parameter 12-lead A-ECG score is retrospectively significantly more sensitive and specific than pooled, age-specific conventional ECG criteria for detecting MYBPC3-HCM and in distinguishing such patients from healthy controls, including endurance-trained athletes.
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