| 1. |
|
|
| 2. |
- Andersson, Åke, et al.
(författare)
-
Single-photon hot-electron ionization of C70
- 2023
-
Ingår i: Physical Review A. - 2469-9926 .- 2469-9934. ; 107:1
-
Tidskriftsartikel (refereegranskat)abstract
- Gas phase C70 molecules have been ionized with single photons of energies between 16 and 70 eV, and the electron spectra measured with velocity map imaging in coincidence with the ions. The doubly ionized and unfragmented species was present at photon energies of 22 eV and up, and triply charged ions were present from 55 eV. The low-kinetic-energy parts of the spectra are explained with thermal emission of transient hot electrons. We propose a generally applicable mechanism, named resonance ionization shadowing, for the creation of hot electrons by absorption of above-threshold energy photons.
|
|
| 3. |
- Chen, Fuqiang, et al.
(författare)
-
Radiative cooling of cationic carbon clusters, CN+, N=8,10,13-16
- 2019
-
Ingår i: Physical Chemistry Chemical Physics - PCCP. - : Royal Society of Chemistry (RSC). - 1463-9076 .- 1463-9084. ; 21, s. 1587-1596
-
Tidskriftsartikel (refereegranskat)abstract
- The radiative cooling of highly excited carbon cluster cations of sizes N = 8, 10, 13–16 has been studied in an electrostatic storage ring. The cooling rate constants vary with cluster size from a maximum at N = 8 of 2.6 × 104 s−1 and a minimum at N = 13 of 4.4 × 103 s−1. The high rates indicate that photon emission takes place from electronically excited ions, providing a strong stabilizing cooling of the molecules.
|
|
| 4. |
- Collins, Marnie, et al.
(författare)
-
Benefits and Adverse Events in Younger Versus Older Patients Receiving Neoadjuvant Chemotherapy for Osteosarcoma: Findings From a Meta-Analysis.
- 2013
-
Ingår i: Journal of Clinical Oncology. - 1527-7755. ; 31:18, s. 130-2303
-
Tidskriftsartikel (refereegranskat)abstract
- PURPOSEThe LIVESTRONG Young Adult Alliance has conducted a meta-analysis of individual patient data from prospective neoadjuvant chemotherapy osteosarcoma studies and registries to examine the relationships of sex, age, and toxicity on survival. PATIENTS AND METHODSSuitable data sets were identified by a survey of published data reported in PubMed. The final pooled data set comprised 4,838 patients from five international cooperative groups.ResultsAfter accounting for important variables known at study entry such as tumor location and histology, females experienced higher overall survival rates than males (P = .005) and children fared better than adolescents and adults (P = .002). Multivariate landmark analysis following surgery indicated that a higher rate of chemotherapy-induced tumor necrosis was associated with longer survival (P < .001), as was female sex (P = .004) and the incidence of grade 3 or 4 mucositis (P = .03). Age group was not statistically significant in this landmark analysis (P = .12). Females reported higher rates of grade 3 or 4 thrombocytopenia relative to males (P < .001). Children reported the highest rates of grade 3 or 4 neutropenia (P < .001) and thrombocytopenia (P < .001). The achievement of good tumor necrosis was higher for females than for males (P = .002) and for children than for adults (P < .001). CONCLUSIONThese results suggest fundamental differences in the way chemotherapy is handled by females compared with males and by children compared with older populations. These differences may influence survival in a disease in which chemotherapy is critical to overall outcomes.
|
|
| 5. |
- Ferrari, Piero, et al.
(författare)
-
Radiative cooling of size-selected gas phase clusters
- 2019
-
Ingår i: International reviews in physical chemistry. - 0144-235X .- 1366-591X. ; 38:3-4, s. 405-440
-
Tidskriftsartikel (refereegranskat)abstract
- Predicted almost forty years ago, the radiation from thermally populated excited electronic states has recently been recognised as an important cooling mechanism in free molecules and clusters. It has presently been observed from both inorganic clusters and carbonbased molecules in molecular beams and ion storage devices. Experiments have demonstrated that many of these systems radiate at rates approaching microsecond time scales, and often with a distinct dependence on the precise number of atoms in the system. The radiation acts as a strongly stabilising factor against both unimolecular decay and thermal electron emission. In astrophysical context, radiative cooling provides a mechanism to dissipate internal energy in star-forming processes, and stabilises molecules selectively in the circumstellar medium. The consequences of an active radiative cooling channel for nanoparticle production will likewise favour special sizes in non-equilibrium formation processes. In this review, the radiative cooling of clusters is presented and illustrated with examples of experiments performed on small carbon, metal, and semiconductor clusters, and on PAH molecules. The experimental and theoretical techniques used are discussed, together with the consequences of radiative cooling on size-to-size stability patterns of clusters.
|
|
| 6. |
- Ferrari, Piero, et al.
(författare)
-
The effect of radiative cooling on the size-dependent stability of small boron clusters
- 2018
-
Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics. - 1050-2947. ; 98
-
Tidskriftsartikel (refereegranskat)abstract
- The mass spectrum of cationic boron clusters, BN+ (N = 5 − 20), after photoexcitation demonstrates that radiative cooling is an important, though often neglected, process in determining the relative stability of small and isolated particles. The observed intensities inmass spectra suggest that B5+, B11+, B13+, and B15+ are particularly stable clusters, consistent with density-functional theory calculations. Quantitative agreement, however, is only obtained if radiative cooling is included in the analysis.All clusters are found to radiate onmicrosecond timescales, suggesting recurrent fluorescence as the dominant photon emission process.
|
|
| 7. |
- Ferrari, Piero, et al.
(författare)
-
Thermal radiation and fragmentation pathways of photo-excited silicon clusters
- 2015
-
Ingår i: Journal of Chemical Physics. - : AIP Publishing. - 0021-9606 .- 1089-7690. ; 143:22
-
Tidskriftsartikel (refereegranskat)abstract
- The fragmentation of laser heated silicon clusters was studied by time-of-flight mass spectrometry. For Si+n (n = 5–19, 21), the lowest energy fragmentation pathways were identified as the metastable decay channel occurring after the primary acceleration of the ions. The radiative cooling of laser excited Si+n (n = 5–9, 11, and 13) was quantified via its quenching effect on the amount of metastable fragmentation. The quenching varied strongly with cluster size, from no observable amount for Si+7 to a cooling constant of 3 · 10E5 s−1 for Si+13. In addition, based on the observed fragmentation channels, the ionization energies and the relative binding energies of the clusters were partially ordered, and several ionization energies have been bracketed more precisely.
|
|
| 8. |
- Ferrari, Stefano, et al.
(författare)
-
EURO-B.O.S.S. : A European study on chemotherapy in bone-sarcoma patients aged over 40: Outcome in primary high-grade osteosarcoma
- 2018
-
Ingår i: Tumori. - : SAGE Publications. - 0300-8916 .- 2038-2529. ; 104:1, s. 30-36
-
Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: The EUROpean Bone Over 40 Sarcoma Study (EURO-B.O.S.S.) was the first prospective international study for patients 41-65 years old with high-grade bone sarcoma treated with an intensive chemotherapy regimen derived from protocols for younger patients with high-grade skeletal osteosarcoma.METHODS: Chemotherapy based on doxorubicin, cisplatin, ifosfamide, and methotrexate was suggested, but patients treated with other regimens at the investigators' choice were also eligible for the study.RESULTS: The present report focuses on the subgroup of 218 patients with primary high-grade osteosarcoma. With a median follow-up of 47 months, the 5-year probability of overall survival (OS) was 66% in patients with localized disease and 22% in case of synchronous metastases. The 5-year OS in patients with localized disease was 29% in pelvic tumors, and 70% and 73% for extremity or craniofacial locations, respectively. In primary chemotherapy, tumor necrosis ≥90% was reported in 21% of the patients. There were no toxic deaths; however, hematological toxicity was considerable with 32% of patients experiencing 1 or more episodes of neutropenic fever. The incidence of nephrotoxicity and neurotoxicity (mainly peripheral) was 28% and 24%, respectively. After methotrexate, 23% of patients experienced delayed excretion, in 4 cases with nephrotoxicity.CONCLUSIONS: In patients over 40 years of age with primary high-grade osteosarcoma, an aggressive approach with chemotherapy and surgery can offer the probability of survival similar to that achieved in younger patients. Chemotherapy-related toxicity is significant and generally higher than that reported in younger cohorts of osteosarcoma patients treated with more intensive regimens.
|
|
| 9. |
- Gaspar, Nathalie, et al.
(författare)
-
Ewing Sarcoma: Current Management and Future Approaches Through Collaboration.
- 2015
-
Ingår i: Journal of Clinical Oncology. - 1527-7755. ; 33:27, s. 140-3036
-
Forskningsöversikt (refereegranskat)abstract
- Ewing sarcoma (ES) is an aggressive sarcoma of bone and soft tissue occurring at any age with a peak incidence in adolescents and young adults. The treatment of ES relies on a multidisciplinary approach, coupling risk-adapted intensive neoadjuvant and adjuvant chemotherapies with surgery and/or radiotherapy for control of the primary site and possible metastatic disease. The optimization of ES multimodality therapeutic strategies has resulted from the efforts of several national and international groups in Europe and North America and from cooperation between pediatric and medical oncologists. Successive first-line trials addressed the efficacy of various cyclic combinations of drugs incorporating doxorubicin, vincristine, cyclophosphamide, ifosfamide, etoposide, and dactinomycin and identified prognostic factors now used to tailor therapies. The role of high-dose chemotherapy is still debated. Current 5-year overall survival for patients with localized disease is 65% to 75%. Patients with metastases have a 5-year overall survival < 30%, except for those with isolated pulmonary metastasis (approximately 50%). Patients with recurrence have a dismal prognosis. The many insights into the biology of the EWS-FLI1 protein in the initiation and progression of ES remain to be translated into novel therapeutic strategies. Current options and future approaches will be discussed.
|
|
| 10. |
|
|
