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| 2. |
- Filipsson, Magnus, et al.
(författare)
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Efterbehandling av gruvavfall med morän/grönlutslam i tätskiktskonstruktionen : Massor med fördelar
- 2015
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Ingår i: Bygg och Teknik. - 0281-658X .- 2002-8350. ; :1, s. 66-70
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Dagens praxis för täckning av sulfidhaltiga gråbergsrester är att täcka med morän. Det görs som ”kvalificerad täckning” genom att lägga på ett tätskikt med lerig morän som packas tätt. I ett önskescenario finns siltig/lerig morän i anslutning till området som är tillräckligt tätt och som kan användas för att anlägga tätskikt. Erfarenhet visar dock att täta moräner förekommer sällan i gruvans närområde och funktionen som syrebarriär inte alltid uppfylls av lokalt förekommande morän. Alternativet är att använda andra tätskiktsmaterial, bentonitmatta, lera etcetera eller att modifiera lokalt förekommande morän. Ett alternativ är att modifiera lokalt förekommande morän genom inblandning av grönlutslam. Grönlutslammet har stor vattenhållande förmåga och en inblandning på cirka tio procent grönlutslam i siktad morän förbättrar moränens funktion som tätskikt avsevärt.Ett vanligt sätt att efterbehandla gruvavfall är att täcka det med ett skikt som hindrar syret att nå avfallet och därmed hindra oxidationen, även kallad kvalificerad täckning. Huvudfunktionkskravet är att minimera syretransporten och främst syrediffusionen över tid, vilket innebär i praktiken att tätskiktets hydrauliska konduktivitet ska vara under 10-8 m/s. I ett önskescenario finns siltig/lerig morän i anslutning till området som är tillräckligt tätt och som kan användas för att anlägga dessa skikt.
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| 3. |
- Filipsson, Monika, et al.
(författare)
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Perception of uncertainties and quality in risk assessments by people working with risk assessments
- 2013
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Ingår i: Abstracts of the 2013 Conference of the International Society of Environmental Epidemiology (ISEE), the International Society of Exposure Science (ISES), and the International Society of Indoor Air Quality and Climate (ISIAQ).. ; , s. Abstract Number : 3978-
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Konferensbidrag (refereegranskat)abstract
- Background About 80,000 possible contaminated sites have been identified in Sweden. Assessing the risk posed by these sites and, if necessary, remediating the soil is associated with high costs. It is thus important that these assessments are reliable. A problem with current methods is that uncertainty and variability are often not accounted for. Different individuals have different physiology and behaviour and soil composition differs at various sites which can be considered in probabilistic methods. This requires tools that are user-friendly and cost and time-efficient. Information about the perception of risk assessments, uncertainty and tools wanted by people working with risk assessments is therefore needed.Aims The aim of this study is to investigate whether people working with risk assessments in practice find that these assessments are of sufficient quality, whether it is important to consider uncertainty and variability and which tools they may need to be able to consider these questions.Methods A questionnaire was sent to people working with the risk assessment of contaminated sites at government authorities and consultancies in Sweden. Results The data collected suggest that the majority of respondents find that risk assessment quality in general would need to be improved. Important factors to achieve this include a greater knowledge of the individuals involved in risk assessments, more financial resources, greater knowledge in form of new research and more time. The respondents also find it very important to characterize both uncertainty and variability, and to do this several respondents want more tools such as literature and databases with information about critical exposure factors and manuals.ConclusionsAccording to personnel involved in the risk assessment of contaminated sites, the quality of the assessment should be enhanced and different tools would be useful to facilitate the characterization of uncertainty and variability.
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- Holmgren, Kerstin, et al.
(författare)
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Harrens tillväxt i Vättern
- 2013
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Rapport (populärvet., debatt m.m.)abstract
- Beståndet av harr i Vättern har med stor sannolikhet minskat kraftigt på senare år. Harren fångas inte upp i tillräckligt hög grad av befintliga övervakningsprogram för fisk (dels pga sitt levnadssätt, dels övervakningsprogrammens utformning)men trenden för fångst i fritidsfiske och enskilda fiskares observationer tyder på att beståndet gått tillbaka sedan slutet av 1990-talet. Det är således viktigt att förbättra kunskapen om harr i Vättern. Vi har studerat tillväxten hos harr genom att analysera de tillgängliga åldersprover från Vättern som arkiverats genom åren. Eftersom harr fångas så sällan är materialet relativt litet. De totalt 177 harrar som vi funnit i olika arkiv delades in i fem olika tidsperioder baserat på fångstdatum. Perioderna var 1935-1936; 1964-66; 1971-80; 1987-2001 och 2009-2012. Harrarna fångades främst i provfisken med översiktsnät eller i kommersiellt fiske samt i samband med sportfiske antingen i flugfiske med spö eller med flugutter. I analyserna användes endast fjäll. Först skattades fiskens slutliga fjällålder. Därefter tillbakaräknades storlek vid given ålder genom att använda sambandet mellan fjällets totalradie och fiskens totallängd vid fångsttillfället. Fjällåldern varierade mellan ett och elva år. Inga tecken på de sigmoidala tillväxtmönster som ibland finns hos fiskarter som skiftar födoslag kunde noteras. Tillväxten tycktes variera mellan de undersökta tidsperioderna. Särskilt den sista perioden (2009-2012) avvek med en väsentligt större variation i tillväxt och en lägre storlek vid åldrarna två och tre år. Harren tycktes ha snabbast tillväxt under perioden 1964-1966.
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- Manousou, Sofia, 1979, et al.
(författare)
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Role of iodine-containing multivitamins during pregnancy for children's brain function: protocol of an ongoing randomised controlled trial: the SWIDDICH study.
- 2018
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Ingår i: BMJ open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 8:4
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Tidskriftsartikel (refereegranskat)abstract
- Iodine is essential for normal brain development. Moderate and severe fetal iodine deficiency results in substantial to serious developmental delay in children. Mild iodine deficiency in pregnancy is associated with neurodevelopmental deficits in the offspring, but evidence from randomised trials is lacking. The aim of the Swedish Iodine in Pregnancy and Development in Children study is to determine the effect of daily supplementation with 150µg iodine during pregnancy on the offspring's neuropsychological development up to 14 years of age.Thyroid healthy pregnant women (n=1275: age range 18-40 years) at ≤12 weeks gestation will be randomly assigned to receive multivitamin supplements containing 150µg iodine or non-iodine-containing multivitamin daily throughout pregnancy. As a primary outcome, IQ will be measured in the offspring at 7 years (Wechsler Intelligence Scale for Children-V). As secondary outcomes, IQ will be measured at 3.5 and 14 years, psychomotor development at 18 months and 7 years, and behaviour at 3.5, 7 and 14 years. Iodine status (urinary iodine concentration) will be measured during pregnancy and in the offspring at 3.5, 7 and 14 years. Thyroid function (thyroid hormones, thyroglobulin), and deiodinase type 2 polymorphisms will be measured during pregnancy and in the offspring at 7 and 14 years. Structural MRI or other relevant structural or functional brain imaging procedures will be performed in a subgroup of children at 7 and 14 years. Background and socioeconomic information will be collected at all follow-up times.This study is approved by the Ethics Committee in Göteborg, Sweden (Diary numbers: 431-12 approved 18 June 2012 (pregnancy part) and 1089-16 approved 8 February 2017 (children follow-up)). According to Swedish regulations, dietary supplements are governed by the National Food Agency and not by the Medical Product Agency. Therefore, there is no requirement for a monitoring committee and the National Food Agency does not perform any audits of trial conduct. The trial will be conducted in accordance with the Declaration of Helsinki. The participating sites will be contacted regarding important protocol changes, both orally and in writing, and the trial registry database will be updated accordingly. Study results will be presented at relevant conferences, and submitted to peer-reviewed journals with open access in the fields of endocrinology, paediatrics and nutrition. After the appropriate embargo period, the results will be communicated to participants, healthcare professionals at the maternal healthcare centres, the public and other relevant groups, such as the national guideline group for thyroid and pregnancy and the National Food Agency.NCT02378246; Pre-results.
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| 7. |
- Miskovsky, Karel, et al.
(författare)
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The resurrection of a biologically dead lake : a case study from northern Sweden
- 2012
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Ingår i: Heavy Metals in the Environment. - The Netherlands : Maralte Publishers. - 9789490970000 - 9789490970079
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Bokkapitel (refereegranskat)abstract
- A major release of heavy metals to surface water in Sweden is derived from oxidation of sulfidic waste sand and waste rock. The Lake Hornträsket in Northern Sweden has experienced a gradual loss of fish over the last three decades caused by leaching from abandoned zinc–copper mines. In 2002, a semi-quantitative budget was brought forward which indicated one of three abandoned zinc–copper mines as the major source of metals to the lake. Copper has been identified as the main toxicant and the proximity of the Hornträsk mine to the lake allows little retention of copper before the drainage water reaches the lake. Several remediation measures such as diversion of drainage from upstream unpolluted areas and neutralization of the coarse sulfidic waste rock by injection and sprinkling with mesa-chalk (a waste product from paper mills) have been tested and found to be partially successful. This has resulted in decreasing levels of heavy metals in the lake and notably of copper concentrations. It has been found necessary to remove sulfide ore from some hot spots that could be identified by groundwater analysis from a dense network of piezometers. It is expected that the fish population will recover in 5–6 years as a result of the remediation.
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| 8. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 9. |
- Sofizadeh, Sheyda, et al.
(författare)
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Effect of Liraglutide on Times in Glycaemic Ranges as Assessed by CGM for Type 2 Diabetes Patients Treated With Multiple Daily Insulin Injections
- 2019
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Ingår i: Diabetes Therapy. - : Springer Science and Business Media LLC. - 1869-6953 .- 1869-6961. ; 10:6, s. 2115-2130
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: The effects of the GLP-1 analogue liraglutide on time in hypoglycaemia, time in hyperglycaemia, and time in range for type 2 diabetes patients initially treated with multiple daily insulin injections (MDI) were investigated. Variables associated with hypoglycaemia in the current population were also identified. Methods: Analyses were based on data from a previously performed double-blind, placebo-controlled trial in which 124 MDI-treated patients with type 2 diabetes were randomized to liraglutide or placebo. Masked continuous glucose monitoring (CGM) was performed at baseline and week 24 in 99 participants. Results: The mean time in hypoglycaemia was similar for participants receiving liraglutide and those receiving placebo after 24 weeks of treatment. Mean time in target was greater in the liraglutide group than in the placebo group: 430 versus 244 min/24 h (p < 0.001) and 960 versus 695 min/24 h (p < 0.001) for the two glycaemic ranges considered, 4–7 mmol/l and 4–10 mmol/l, respectively. Mean time in hyperglycaemia was lower in the liraglutide group: 457 versus 723 min/24 h (p = 0.001) and 134 versus 264 min/24 h (p = 0.023) for the two cutoffs considered, > 10 mmol/l and > 14 mmol/l, respectively. Lower mean glucose level, lower C-peptide, and higher glucose variability were associated with an increased risk of hypoglycaemia in both treatment groups. Higher proinsulin level was associated with a lower risk of hypoglycaemia in the liraglutide group. Conclusion: For type 2 diabetes patients initially treated with MDI, introducing liraglutide had a beneficial effect on glucose profiles estimated by masked CGM. Mean glucose level, glycaemic variability, C-peptide, and proinsulin level influenced the risk of hypoglycaemia in this population. Trial Registration: ClinicalTrials.gov, number (EudraCT nr: 2012-001941-42). Funding: Novo Nordisk funded this study. The Diabetes Research Unit, NU-Hospital Group funded the journal’s Rapid Service Fee.
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