| 1. |
- Bentley, Michael J., et al.
(författare)
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A community-based geological reconstruction of Antarctic Ice Sheet deglaciation since the Last Glacial Maximum
- 2014
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Ingår i: Quaternary Science Reviews. - : Elsevier BV. - 0277-3791 .- 1873-457X. ; 100, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- A robust understanding of Antarctic Ice Sheet deglacial history since the Last Glacial Maximum is important in order to constrain ice sheet and glacial-isostatic adjustment models, and to explore the forcing mechanisms responsible for ice sheet retreat. Such understanding can be derived from a broad range of geological and glaciological datasets and recent decades have seen an upsurge in such data gathering around the continent and Sub-Antarctic islands. Here, we report a new synthesis of those datasets, based on an accompanying series of reviews of the geological data, organised by sector. We present a series of timeslice maps for 20 ka, 15 ka, 10 ka and 5 ka, including grounding line position and ice sheet thickness changes, along with a clear assessment of levels of confidence. The reconstruction shows that the Antarctic Ice sheet did not everywhere reach the continental shelf edge at its maximum, that initial retreat was asynchronous, and that the spatial pattern of deglaciation was highly variable, particularly on the inner shelf. The deglacial reconstruction is consistent with a moderate overall excess ice volume and with a relatively small Antarctic contribution to meltwater pulse la. We discuss key areas of uncertainty both around the continent and by time interval, and we highlight potential priorities for future work. The synthesis is intended to be a resource for the modelling and glacial geological community.
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| 2. |
- Campbell, PJ, et al.
(författare)
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Pan-cancer analysis of whole genomes
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
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Tidskriftsartikel (refereegranskat)abstract
- Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
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| 3. |
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| 4. |
- Fink, Gerhard, et al.
(författare)
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Glued Connections in Timber Structures
- 2019
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Ingår i: Rethinking Wood: Future Dimensions of Timber Assembly. - 9783035616897 ; , s. 116-127
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- As a naturally grown material, the dimensions of structural timber exhibit certain limitations. In order also to use timber for larger structures and wider spans, different techniques have been developed to overcome these limitations. The development of adhesive offered new possibilities for timber structures. In this contribution, the structural behavior of glued connections is introduced briefly. Different types of glued connections currently used in practice are summarized and discussed. Their potential with respect to future applications will be evaluated and new and innovative solutions will be presented. The contribution is limited to structural adhesive joints used to transfer loads in a defined area usually between two members.
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| 5. |
- Fink, Gerhard, et al.
(författare)
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HOLISTIC DESIGN OF TALLER TIMBER BUILDINGS - COST ACTION HELEN (CA20139)
- 2023
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Ingår i: World Conference on Timber Engineering (WCTE 2023). ; 2, s. 1001-1008
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Konferensbidrag (refereegranskat)abstract
- With the worldwide construction sector being responsible for one third of carbon dioxide emissions, as well as forty percent of the world’s energy use and waste production, a shift to sustainable and renewable construction techniques is crucial. Engineered timber, a champion of sustainable construction materials, has evolved to a stage that enables the construction of not only family housing but also taller buildings so far commonly built from concrete or steel. Designing taller timber buildings made is more demanding than their concrete and steel counterparts. Whereas different design aspects (architectural, structural, fire safety, acoustics, etc.) of concrete buildings can work almost independently, the design of taller timber buildings should be performed with intensive collaboration among the design teams. It is therefore crucial to address taller multi-storey timber buildings from a collaborative and interdisciplinary perspective, considering static, dynamic, fire, acoustic, human health, and other aspects in parallel and not in isolation. Only through interdisciplinary analysis and interaction can a set of holistic design guidelines be developed that will enable the safe construction of taller timber buildings, as well as respect human wellbeing demands. In this paper, the COST Action CA20139 will be presented and the main aims will be discussed.
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| 6. |
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| 7. |
- Frühwald Hansson, Eva, et al.
(författare)
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Failure analysis on timber structures
- 2011
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Ingår i: Assessment of failures and malfunctions - guidelines for quality control. - 9783844001617
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Bokkapitel (refereegranskat)
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| 8. |
- Jockwer, Robert, 1984, et al.
(författare)
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Advanced teaching methods in the course "Timber Engineering" in the Nordic countries
- 2021
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Ingår i: World Conference on Timber Engineering 2021, WCTE 2021.
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Konferensbidrag (refereegranskat)abstract
- There is a general need for the education of more structural engineers and architects that are able to design timber structures. This includes both the education of new engineers as well as the further education of structural engineers that are experienced in other building materials. Digital tools have proven to be essential in the education and will become even more important in future. This might be of particular relevance for Nordic countries, especially remote regions. In this paper selected modern teaching methods will be addressed and discussed in respect to timber engineering. The experience with applied teaching methods (traditional and new once) as well as the students’ feedback and response during the course will be presented. Furthermore, the paper will address issues such as lifelong learning, digitalisation as well as the interaction between education and the industry.
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