| 1. |
- Osorio, Ana, et al.
(författare)
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DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers.
- 2014
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Ingår i: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7404. ; 10:4
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Tidskriftsartikel (refereegranskat)abstract
- Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of synthetic lethality that exists between one of the components of the BER pathway, PARP1 (poly ADP ribose polymerase), and both BRCA1 and BRCA2. In the present study, we have performed a comprehensive analysis of 18 genes involved in BER using a tagging SNP approach in a large series of BRCA1 and BRCA2 mutation carriers. 144 SNPs were analyzed in a two stage study involving 23,463 carriers from the CIMBA consortium (the Consortium of Investigators of Modifiers of BRCA1 and BRCA2). Eleven SNPs showed evidence of association with breast and/or ovarian cancer at p<0.05 in the combined analysis. Four of the five genes for which strongest evidence of association was observed were DNA glycosylases. The strongest evidence was for rs1466785 in the NEIL2 (endonuclease VIII-like 2) gene (HR: 1.09, 95% CI (1.03-1.16), p = 2.7×10-3) for association with breast cancer risk in BRCA2 mutation carriers, and rs2304277 in the OGG1 (8-guanine DNA glycosylase) gene, with ovarian cancer risk in BRCA1 mutation carriers (HR: 1.12 95%CI: 1.03-1.21, p = 4.8×10-3). DNA glycosylases involved in the first steps of the BER pathway may be associated with cancer risk in BRCA1/2 mutation carriers and should be more comprehensively studied.
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| 2. |
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| 3. |
- Sandberg, Dick, et al.
(författare)
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Process Control and Grading in Primary Wood Processing
- 2023
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Ingår i: Springer Handbook of Wood Science and Technology. - : Springer Science and Business Media Deutschland GmbH. - 9783030813147 - 9783030813154 ; , s. 1019-1073
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Bokkapitel (refereegranskat)abstract
- Round timber and wood products are measured, sorted, and graded at different stages in the wood-value chain starting already at the stem level in the forest. This chapter gives an overview of grading methodologies and techniques for the measurement and grading of round timber, sawn timber, veneer, and wood-panel products. The section concerning round timber focuses on the grading and sorting of logs for sawmill and veneer production. For sawn timber, visual and strength grading are discussed, for both the European and the North American markets. Techniques for measurement and process control in the wood-panel industry are finally discussed, where the different industrial methods used today are in focus rather than the specific grading rules used in the industry. The technologies presented have a broader application outside the field of the wood-panel industry, and can be of interest for the measurement of wood composites in general.
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| 4. |
- Sing, M., et al.
(författare)
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Electronic structure studies of pressure-polymerized C60
- 1999
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Ingår i: Synthetic Metals vol. 103. - : Elsevier B.V.. ; 103:1-3, s. 2454-2455
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Konferensbidrag (refereegranskat)abstract
- We have investigated the electronic structure of one and two-dimensional C60 polymers with regard to both their low-lying excitations and C 1s excitation spectra by means of electron energy-loss spectroscopy in transmission. We compare the results with those for pristine C60. In general, the spectra for the polymers resemble those for pristine C60 but show a broadening due to both the lowering of the symmetry and the increased intermolecular overlap. This is also reflected by a reduction of the optical gap in comparison with pristine C60.
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