| 1. |
- Campbell, PJ, et al.
(författare)
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Pan-cancer analysis of whole genomes
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
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Tidskriftsartikel (refereegranskat)abstract
- Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
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| 2. |
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| 3. |
- Burmeister, F, et al.
(författare)
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Nonadiabatic effects in photoelectron spectra of HCl and DCl. I. Experiment
- 2002
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Ingår i: Physical Review A (Atomic, Molecular and Optical Physics). - 1050-2947. ; 65:1
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Tidskriftsartikel (refereegranskat)abstract
- The HCl inner-valence photoelectron band at 26 eV binding energy has been recorded at high resolution. Discrete peaks arising from at least two separate vibrational progressions are superimposed on the broad continuum. Fano profiles are visible in one of the progressions. This indicates interference between superimposed electronic states, where weak avoided crossing allows two adiabatic states to couple. In the isotopic DCl molecular spectrum, the discrete lines are less pronounced, due to slower dissociation and therefore less coupling between the continuum and the bound state.
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| 4. |
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| 5. |
- Fink, RF, et al.
(författare)
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Spin-orbit selectivity observed for the HCl+ ((X)over-tilde (II)-I-2) state using resonant photoemission
- 2002
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Ingår i: Physical Review A (Atomic, Molecular and Optical Physics). - 1050-2947. ; 65:3
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Tidskriftsartikel (refereegranskat)abstract
- We report the experimental observation of a strongly selective population of the spin-orbit components in the HCl+ (X) over tilde (2)Pi(Omega) states after excitation into the dissociative 2p(-1)6sigma* core excited state. A progression of highly excited vibrational states with either the Omega=3/2 or Omega=1/2 component of the final state is populated, respectively, when the excitation is tuned in the 2p(3/2)(-1)6sigma*or2p(1/2)(-1)6 sigma* part of the resonance. This effect is explained theoretically to be due to the orientational selectivity of the excitation process and the preference of the L-2,L-3 VV Auger process to produce valence holes with the same orientation as the core holes.
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| 6. |
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| 7. |
- Fink, RF, et al.
(författare)
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Theory and ab initio calculations of 2p photoabsorption spectra: The lowest Rydberg resonances in HCl
- 1999
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Ingår i: JOURNAL OF CHEMICAL PHYSICS. - : AMER INST PHYSICS. - 0021-9606. ; 111:22, s. 10034-10045
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- We present a theory for 2p core excitation spectra of linear molecules that explicitly includes the spin-orbit splitting of the 2p core orbitals as well as all nonrelativistic effects. This is applied to the absorption spectrum of HCl at the 2p --> 6 sigm
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| 8. |
- Hjelte, I, et al.
(författare)
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Evidence for ultra-fast dissociation of molecular water from resonant Auger spectroscopy
- 2001
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Ingår i: CHEMICAL PHYSICS LETTERS. - : ELSEVIER SCIENCE BV. - 0009-2614. ; 334:1-3, s. 151-158
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Tidskriftsartikel (refereegranskat)abstract
- We present direct evidence for ultra-fast dissociation of molecular water in connection photo-excitation of the Ols --> 4a(1) resonance. The core-excited H2O molecules are shown to dissociate into core-excited O*H and neutral H on a time scale comparable
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| 9. |
- Lindblad, A, et al.
(författare)
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Postcollision interaction in noble gas clusters: Observation of differences in surface and bulk line shapes
- 2005
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Ingår i: Journal of Chemical Physics. - : AIP Publishing. - 0021-9606 .- 1089-7690. ; 123:21
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Tidskriftsartikel (refereegranskat)abstract
- The surface and bulk components of the x-ray photoelectron spectra of free noble gas clusters are shown to display differences in the influence of postcollision interaction between the photoelectron and the Auger electron on the spectral line shape; the bulk component is observed to be less affected than the surface and atomic parts of the spectra. A model for postcollision interaction in nonmetallic solids and clusters is also provided which takes the polarization screening into account. Core-level photoelectron spectra of Ar, Kr, and Xe have been recorded to verify the dependence of the postcollision interaction effect on the polarizability of the sample.
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| 10. |
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