| 1. |
- Asadollahi, Mojtaba, et al.
(författare)
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Ethnopharmacological studies, chemical composition, antibacterial and cytotoxic activities of essential oils of eleven Salvia in Iran
- 2019
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Ingår i: Journal of Herbal Medicine. - : Elsevier BV. - 2210-8033 .- 2210-8041. ; 17-18
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Tidskriftsartikel (refereegranskat)abstract
- The chemical compositions of essential oils (EOs) of 11 Salvia species collected from different localities in Iran were analyzed by GC-FID and GC–MS. Altogether, 58 compounds were identified. α- and β-Pinene, 1,8-cineol, β-caryophyllene and sclareol were detected as the major constituents. Moreover, the cytotoxic activity of the EOs were assessed against 3 human cancer cell lines (HT-29, MCF-7 and MOLT-4) using MTT reduction assay. The oils displayed weak to moderate cytotoxic activities. The antibacterial activities of the oils were assayed on three Gram positive and four Gram negative bacteria by microdilution and agar disc diffusion methods. The antibacterial activities of the oils were compared with those previously reported for some of the sage species. Among the tested bacteria, Bacillus subtilis and Salmonella typhi were the most susceptible organisms with MICs 0.312 and 2.5 mg/ mL media against all of the tested EOs. The authors reviewed ethnopharmacological information published on Salvia species of the world and compared them with the data of those species which were used in the Iranian folk medicine. Among the Iranian sages, S. mirzayanii and S. hydrangea are used by the inhabitants of the Southwestern towns of Iran as medicinal plants. Aerial parts of S. mirzayanii are used for the treatment of diabetes, stomach ache, infections, inflammatory diseases, spasms, gastrointestinal disorders, and as an astringent, carminative, antiseptic and smoke medicine, while the flowers of S. hydrangea are used for their anti-inflammatory, spasmolytic, diuretic, sedative and carminative effects and are also used for treating cough, sore throat and fever.
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| 2. |
- Firuzi, Omidreza, et al.
(författare)
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Composition and biological activities of essential oils from four Heracleum species
- 2010
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Ingår i: Food Chemistry. - : Elsevier BV. - 0308-8146 .- 1873-7072. ; 122:1, s. 117-122
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Tidskriftsartikel (refereegranskat)abstract
- The composition of essential oils from aerial parts of Heracleum persicum, a widely used medicinal plant, and three other Heracleum species growing wild in Iran were analysed by GC and GC–MS. Myristicin (53.6%), (E)-anethole (25.0%), hexyl butanoate (29.7%) and elemicin (41.1%) were the major compounds of Heracleum pastinacifolium, H. persicum, Heracleum rechingeri and Heracleum transcaucasicum, respectively. Cytotoxic activity assessed on three human cancer cell lines (HeLa, LS180 and Raji), showed that essential oils from H. transcaucasicum (IC50 values; 0.362–0.594 mg/ml) followed by H. pastinacifolium (0.497–1.398 mg/ml) had moderate antitumoral activities. In the DPPH radical scavenging assay, H. pastinacifolium and H. persicum oils showed the highest activities with IC50 values of 7.3 and 7.4 mg/ml, respectively. Antioxidant activity correlated well with the total phenolic content of the oils. None of the essential oils showed significant antimicrobial activities.
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| 3. |
- Ghoran, Salar Hafez, et al.
(författare)
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Sappanin-type homoisoflavonoids from Scilla bisotunensis Speta. : Cytotoxicity, molecular docking, and chemotaxonomic significance
- 2023
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Ingår i: Journal of Molecular Structure. - : Elsevier. - 0022-2860 .- 1872-8014. ; 1273
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Tidskriftsartikel (refereegranskat)abstract
- Phytochemical investigation of the chloroform extract of Scilla bisotunensis Speta. bulbs led to the isolation and structure elucidation of six sappinane-4-one ( 1-4, 7, 9 ) and three 3,9-dehydrosappinan-4-one ( 5, 6, 8 ) homoisoflavonoids. The structures of compounds 1 -9 were established based on extensive NMR, ESIMS, UV, and ECD spectra, and also by comparison with the previously reported spectroscopic data. The in vitro cytotoxicity of sappanin-type homoisoflavonoids 1 -9 was assayed against HT-29 human colorectal cancer cells using sulforhodamine B assay. Compounds 8 and 9 showed higher cytotoxic effects with IC50 of 5.3 and 6.1 mu g/mL, respectively, while compounds 3, 5 , and 7 exhibited moderate activity with IC50 ranging from 25 to 37 mu g/mL. Interestingly, molecular docking studies revealed that compounds 1-9 could be potential sarcoma kinase domain inhibitors with binding energies ranging from -7.37 ( 6 ) to -8.34 ( 9 ) kcal/mol when compared with the native inhibitor, purvalanol A of -7.90 kcal/mol. All homoisoflavonoids, except 1 and 5 are reported for the first time in a member of the Scilla genus, while, to the best of our knowledge this is the first phytochemical and biological study on S. bisotunensis. The plant exhibited good chemotaxonomic relationships to the genus Eucomis L'Her. on the basis of comparing their chemical constituents with those reported in the related plant families.
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| 4. |
- Hafez Ghoran, Salar, et al.
(författare)
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Dammarane-type triterpenoid saponins from Salvia russellii Benth
- 2021
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Ingår i: Phytochemistry. - : Elsevier BV. - 0031-9422 .- 1873-3700. ; 184
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Tidskriftsartikel (refereegranskat)abstract
- Three undescribed dammarane-type saponins, russelliinosides A-C, together with a common sterol (β-sitosterol), an abietane diterpenoid (18-hydroxyferruginol), two oleane triterpenoids (daturaolone and oleanolic acid), an ursane triterpenoid (ursolic acid) as well as three 5-hydroxyflavones (cirsimaritin, eupatorin, and salvigenin) were isolated from a dichloromethane extract of the aerial parts of Salvia russellii Benth. The chemical structures of the aforementioned compounds were characterized, using detailed spectroscopic analyses, including high-resolution mass spectrometry and 1D and 2D NMR (1H–1H COSY, TOCSY, HSQC, HMBC and NOESY) spectroscopy as well as physicochemical properties. Cytotoxic effects of S. russellii extract and the three isolated russelliinosides were tested against MCF-7 human breast and A549 lung cancer, as well as non-cancer NIH/3T3 cells using MTT reduction assay. Russelliinosides A and B exhibited cytotoxic activities with IC50 values of 7.1 and 30.7 μg/ml against MCF-7 and 33.9 and 69.4 μg/ml against A549 cells, respectively, while russelliinoside C did not show cytotoxicity against cancer cells. On the other hand, russelliinoside A showed an IC50 value of 31.5 μg/ml against NIH/3T3 cells, while russelliinosides B and C had no effect on the viability of these non-cancer cells.
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| 5. |
- Jassbi, Amir Reza, et al.
(författare)
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Cytotoxic abietane-type diterpenoids from roots of Salvia spinosa and their in Silico pharmacophore modeling
- 2022
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Ingår i: Natural Product Research. - : Informa UK Limited. - 1478-6419 .- 1478-6427. ; 36:12, s. 3183-3188
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Tidskriftsartikel (refereegranskat)abstract
- The roots of Salvia spinosa L. (Lamiaceae) were extracted withhexane, dichloromethane (DCM) and ethyl acetate. The DCMextract exhibited cytotoxic activity (IC50 32.7 mg/mL) against MFC7 breast cancer cell line in MTT colorimetric bioassay. Ferruginol(1), taxodione (2), 12-deoxy-6-hydroxy-6,7-dehydroroyleanone (3),14-deoxycoleon U (4), 15-deoxyfuerstione (5) and taxodone (6)were isolated from the DCM roots extract. Their structures wereelucidated by a combination of spectroscopic analyses includingEIMS and 1H- and 13C NMR spectra. The cytotoxicity of compound3 was determined against MCF-7 and K562 cell lines and compared with the other compounds. A pharmacophore model wasbuilt based on potent input compounds to resolve importantpharmacophore features responsible for cytotoxic activity of theisolated compounds
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| 6. |
- Zare, Somayeh, et al.
(författare)
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Antidiabetic and cytotoxic polyhydroxylated oleanane and ursane type triterpenoids from Salvia grossheimii
- 2020
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Ingår i: Bioorganic chemistry. - : Elsevier BV. - 0045-2068. ; 104
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Tidskriftsartikel (refereegranskat)abstract
- Two polyhydroxylated oleanane and seven ursane triterpenoids were isolated from aerial parts of Salvia grossheimii. The chemical structures of the undescribed triterpenoids (1–6) were characterized using 1 and 2 D NMR and ESI-MS spectral data as; 2α, 3β, 11α –trihydroxy-olean-12- ene (1), 2α, 3β, 11α-trihydroxy-olean-18-ene (2), 2α- acetoxy-urs-12-ene-3β, 11α, 20β-triol (3), 3-keto-urs-12-ene-1β, 11α, 20β -triol (4), 2α, 3β-diacetoxy-urs-12-ene-1β, 11α, 20β -triol (5), and 3β-acetoxy-urs-12-ene-1β, 11α, 20β –triol (6). All compounds were evaluated for the in vitro α-glucosidase inhibitory and cytotoxic activities against MCF-7 human cancer cell line. Compounds 1, 2, 4, and 6 showed in vitro α-glucosidase inhibitory activity with IC50 = 43.6–198.4 µM, which were more potent than the antidiabetic medicine, acarbose. The remaining compounds; 3, and 7–9 showed potent cytotoxic activity (IC50 = 6.2–31.9 µM) against the cancerous cell line, while the potent α-glucosidase inhibitors were inactive. Molecular docking analysis and kinetic studies were applied to investigate the structure activity relationships and mechanisms of the human and Saccharomyces cerevisiae α-glucosidase inhibitory of the purified compounds. Comparing the high cytotoxicity and α-glucosidase inhibitory of the oleanane and ursane type triterpenoids suggest them as potential lead compounds for further research in anticancer and antidiabetic research.
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