| 1. |
|
|
| 2. |
- Dima, Danai, et al.
(författare)
-
Subcortical volumes across the lifespan : Data from 18,605 healthy individuals aged 3-90 years.
- 2022
-
Ingår i: Human Brain Mapping. - : Wiley. - 1065-9471 .- 1097-0193. ; 43:1, s. 452-469
-
Tidskriftsartikel (refereegranskat)abstract
- Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.
|
|
| 3. |
- Frangou, Sophia, et al.
(författare)
-
Cortical thickness across the lifespan : Data from 17,075 healthy individuals aged 3-90 years
- 2022
-
Ingår i: Human Brain Mapping. - : John Wiley & Sons. - 1065-9471 .- 1097-0193. ; 43:1, s. 431-451
-
Tidskriftsartikel (refereegranskat)abstract
- Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.
|
|
| 4. |
- Thompson, Deborah J, et al.
(författare)
-
Genetic predisposition to mosaic Y chromosome loss in blood
- 2019
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 575, s. 652-657
-
Tidskriftsartikel (refereegranskat)abstract
- Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common form of clonal mosaicism1-5, yet our knowledge of the causes and consequences of this is limited. Here, using a computational approach, we estimate that 20% of the male population represented in the UK Biobank study (n = 205,011) has detectable LOY. We identify 156 autosomal genetic determinants of LOY, which we replicate in 757,114 men of European and Japanese ancestry. These loci highlight genes that are involved in cell-cycle regulation and cancer susceptibility, as well as somatic drivers of tumour growth and targets of cancer therapy. We demonstrate that genetic susceptibility to LOY is associated with non-haematological effects on health in both men and women, which supports the hypothesis that clonal haematopoiesis is a biomarker of genomic instability in other tissues. Single-cell RNA sequencing identifies dysregulated expression of autosomal genes in leukocytes with LOY and provides insights into why clonal expansion of these cells may occur. Collectively, these data highlight the value of studying clonal mosaicism to uncover fundamental mechanisms that underlie cancer and other ageing-related diseases.
|
|
| 5. |
- Amano, Tatsuya, et al.
(författare)
-
Transforming Practice : Checklists for Delivering Change
- 2022
-
Ingår i: Transforming Conservation : A Practical Guide to Evidence and Decision Making - A Practical Guide to Evidence and Decision Making. - 9781800648562 - 9781800648586 ; , s. 367-386
-
Bokkapitel (refereegranskat)abstract
- Delivering a revolution in evidence use requires a cultural change across society. For a wide range of groups (practitioners, knowledge brokers, organisations, organisational leaders, policy makers, funders, researchers, journal publishers, the wider conservation community, educators, writers, and journalists), options are described to facilitate a change in practice, and a series of downloadable checklists is provided.
|
|
| 6. |
- O’Brien, Timothy M., et al.
(författare)
-
Provenance, U-Pb detrital zircon geochronology, Hf isotopic analyses, and Cr-spinel geochemistry of the northeast Yukon-Koyukuk Basin : Implications for interior basin development and sedimentation in Alaska
- 2018
-
Ingår i: Geological Society of America Bulletin. - 0016-7606 .- 1943-2674. ; 130:5-6, s. 825-847
-
Tidskriftsartikel (refereegranskat)abstract
- The Yukon-Koyukuk Basin is a large depression that covers ∼118,000 km2 in western interior Alaska and is divided into two subbasins by a volcanic arc assemblage. Interpretations of the depositional setting of the northern Kobuk Koyukuk subbasin vary from a syncollisional forearc basin to a postorogenic successor basin formed by lithospheric extension. New results from sandstones and conglomerates collected from the Kobuk Koyukuk subbasin provide evidence for the timing of basin development, insight into the provenance of coarse siliciclastic sediments, and understanding of the nature of Cretaceous paleogeography and paleodrainage of Arctic Alaska.Early sedimentary rocks of the Kobuk Koyukuk subbasin contain abundant mafic to ultramafic volcanic and plutonic lithic fragments and mafic heavy minerals (e.g., spinel, clinopyroxene, and amphibole). They also contain abundant Middle Triassic to early Late Jurassic zircons (240−160 Ma; peak maximum ca. 200 Ma) that yield highly juvenile Hf isotopic compositions. Geochemistry of chromium spinels (Cr# = 0.17−0.86) suggests crystallization in an immature arc setting that likely developed over mid-ocean-ridge basalt−type crust. These early sediments originated from the mafic and ultramafic rocks of the Angayucham terrane, which was once much more extensive. These results suggest that the Angayucham terrane consists of an obducted Middle Triassic to early Late Jurassic oceanic arc complex that was coeval with oceanic- to continental-margin mafic arc magmatism in the Canadian Cordillera.Our generalized stratigraphy, along with U-Pb ages and Lu-Hf isotope analyses of zircons from sedimentary rocks of the Kobuk Koyukuk subbasin, reflects the tectonic and/or erosional unroofing of the adjacent southern Brooks Range and Ruby terrane. U-Pb ages of detrital zircons collected from the stratigraphically lowest mafic- to ultramafic-rich strata yield maximum depositional ages (107 Ma) that reflect initial erosion of the structurally highest Angayucham terrane and initiation of basin formation and deposition in the late Early Cretaceous. Continued uplift and erosion exposed structurally deeper metamorphic rocks, as revealed by incorporation of low-grade phyllites and eventually higher-grade metamorphic schistose lithic detritus and intermediate-composition (e.g., biotite) to metamorphic (e.g., chloritoid and xenotime) heavy mineral suites into the basin sediments. Differences in detrital zircon signatures between similar-age strata in the Colville foreland basin to the north of the Brooks Range and the Kobuk Koyukuk subbasin indicate that the sediments within the two basins were derived from two different sources, and the Brooks Range orogen acted as a drainage divide during late Early Cretaceous deposition.
|
|
