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1.	Palma Medina, LM, et al. (author) Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia 2023 In: Respiratory research. - 1465-993X. ; 24:1, s. 62- Journal article (peer-reviewed)
2.	Kvedaraite, E, et al. (author) Intestinal stroma guides monocyte differentiation to macrophages through GM-CSF 2024 In: Nature communications. - : Springer Nature. - 2041-1723. ; 15:1, s. 1752- Journal article (peer-reviewed)
3.	Kozlova, I., et al. (author) Anaesthesia and the elemental content of mouse nasal fluid Journal article (peer-reviewed)
4.	Stone, VM, et al. (author) Coxsackievirus B Vaccines Prevent Infection-Accelerated Diabetes in NOD Mice and Have No Disease-Inducing Effect 2021 In: Diabetes. - 1939-327X. ; 70:12, s. 2871-2878 Journal article (peer-reviewed)
5.	Stone, VM, et al. (author) Coxsackievirus B infections are common in Cystic Fibrosis and experimental evidence supports protection by vaccination 2022 In: iScience. - 2589-0042. ; 25:10, s. 105070- Journal article (peer-reviewed)
6.	Lind, K., et al. (author) Coxsackievirus B3 induces the mRNA expression of IFNbeta and viral recognition receptors in human pancreatic islets 2010 In: Diabetologia. - 0012-186X .- 1432-0428. ; 53 Journal article (other academic/artistic)
7.	Christoffersson, G, et al. (author) Mouse Models of Virus-Induced Type 1 Diabetes 2020 In: Methods in molecular biology (Clifton, N.J.). - New York, NY : Springer US. - 1940-6029. ; 2128, s. 93-105 Journal article (peer-reviewed)
8.	Ludvigsson, Johnny, et al. (author) Corona Pandemic : Assisted Isolation and Care to Protect Vulnerable Populations May Allow Us to Shorten the Universal Lock-Down and Gradually Re-open Society 2020 In: Frontiers in Public Health. - : Frontiers Media SA. - 2296-2565. ; 8 Journal article (peer-reviewed)
9.	Stone, Virginia M., et al. (author) Inhibition of Type III Interferon Expression in Intestinal Epithelial Cells-A Strategy Used by Coxsackie B Virus to Evade the Host's Innate Immune Response at the Primary Site of Infection? 2021 In: Microorganisms. - : MDPI AG. - 2076-2607. ; 9:1 Journal article (peer-reviewed)abstract Increasing evidence highlights the importance of the antiviral activities of the type III interferons (IFN lambda s; IL-28A, IL-28B, IL29, and IFN lambda 4) in the intestine. However, many viruses have developed strategies to counteract these defense mechanisms by preventing the production of IFNs. Here we use infection models, a clinical virus isolate, and several molecular biology techniques to demonstrate that both type I and III IFNs induce an antiviral state and attenuate Coxsackievirus group B (CVB) replication in human intestinal epithelial cells (IECs). While treatment of IECs with a viral mimic (poly (I:C)) induced a robust expression of both type I and III IFNs, no such up-regulation was observed after CVB infection. The blunted IFN response was paralleled by a reduction in the abundance of proteins involved in the induction of interferon gene transcription, including TIR-domain-containing adapter-inducing interferon-beta (TRIF), mitochondrial antiviral-signaling protein (MAVS), and the global protein translation initiator eukaryotic translation initiation factor 4G (eIF4G). Taken together, this study highlights a potent anti-Coxsackieviral effect of both type I and III IFNs in cells located at the primary site of infection. Furthermore, we show for the first time that the production of type I and III IFNs in IECs is blocked by CVBs. These findings suggest that CVBs evade the host immune response in order to successfully infect the intestine.

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Result 1-9 of 9

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Type of publication: journal article (9)

Type of content: peer-reviewed (8); other academic/artistic (1)

Author/Editor: Svensson, M. (2); Buggert, M (2); Moll, K (2); Lourda, M (2); Chen, P (1); Sandberg, JK (1); show more...; Eriksson, LI (1); Sinha, I (1); Korsgren, Olle (1); Ljunggren, HG (1); Hyoty, H (1); Michaelsson, J (1); Fischler, B (1); Leslie, David (1); Buschard, Karsten (1); Cilio, Corrado (1); Mallone, Roberto (1); Norrby-Teglund, A (1); Villablanca, EJ (1); Klingström, J (1); Rooyackers, O (1); Aleman, S (1); Ludvigsson, Johnny (1); Lindforss, U (1); Henter, JI (1); Brighenti, S (1); Hjelte, L (1); Larsson, P G (1); Jorns, C (1); Ringqvist, E (1); Strålin, K. (1); Holmlund, Ulrika (1); Sverremark-Ekström, ... (1); Ilonen, Jorma (1); Roomans, G. M. (1); Damdimopoulos, A (1); Chambers, BJ (1); Malmberg, KJ (1); Sorini, C (1); Arnell, H (1); Muvva, JR (1); Garcia, M (1); Jansson, J. (1); Pernemalm, M (1); Babacic, H (1); Nordenvall, C (1); Björkström, NK (1); Lind, K (1); Cornillet, M (1); Palma Medina, LM (1); show less...

University: Karolinska Institutet (8); Uppsala University (2); Royal Institute of Technology (1); Stockholm University (1); Linköping University (1); Lund University (1)

Language: English (8); Undefined language (1)

Research subject (UKÄ/SCB): Medical and Health Sciences (2); Natural sciences (1)

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