| 1. |
- Alsterholm, Mikael, 1977, et al.
(författare)
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Frequency of bacteria, Candida and malassezia species in balanoposthitis.
- 2008
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Ingår i: Acta dermato-venereologica. - : Medical Journals Sweden AB. - 0001-5555 .- 1651-2057. ; 88:4, s. 331-6
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Tidskriftsartikel (refereegranskat)abstract
- Balanoposthitis is an inflammatory disorder of the prepuce and glans penis. Microbes involved in balanoposthitis have been investigated, but no single study has covered the growth of both bacteria, Candida and Malassezia. We report here the prevalence of these microbes in 100 patients with balanoposthitis and in 26 control patients. Among patients with balanoposthitis there was a significantly higher frequency of positive cultures than in the control group (59% and 35%, respectively, p<0.05). In the balanoposthitis group Staphylococcus aureus was found in 19%, group B streptococci in 9%, Candida albicans in 18% and Malassezia in 23% of patients. In the control group S. aureus was not found at all, whereas C. albicans was found in 7.7% and Malassezia in 23% of patients. Different microbes did not correspond with distinct clinical manifestations. In summary, we report increased frequency of microbes, specifically S. aureus, in the area of the prepuce and glans penis in balanoposthitis.
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| 2. |
- Alsterholm, Mikael, 1977, et al.
(författare)
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Fusidic acid-resistant Staphylococcus aureus in impetigo contagiosa and secondarily infected atopic dermatitis.
- 2010
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Ingår i: Acta dermato-venereologica. - : Medical Journals Sweden AB. - 0001-5555. ; 90:1, s. 52-7
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Tidskriftsartikel (refereegranskat)abstract
- Fusidic acid-resistant Staphylococcus aureus (FRSA) has been identified as a causative agent in outbreaks of impetigo and its emergence has been associated with increased use of topical fusidic acid. The frequency of FRSA in atopic dermatitis (AD) has been less extensively investigated. The aim of this study was to investigate the bacterial spectrum and frequency of FRSA in patients with impetigo or secondarily infected AD. A prospective study in our clinic in 2004 to 2008 included 38 patients with impetigo and 37 with secondarily infected AD. S. aureus was the predominant finding in all groups (bullous impetigo 92% (12/13), impetigo 76% (19/25) and secondarily infected AD 89% (33/37)). Seventy-five percent of S. aureus were fusidic acid resistant in bullous impetigo, 32% in impetigo and 6.1% in secondarily infected AD (bullous impetigo vs. AD p < 0.0001, impetigo vs. AD p < 0.05). We then performed a retrospective patient record review including all patients with impetigo or secondarily infected AD seen at the clinic during the first and last year of the prospective study. In the first year 33% (19/58) of the S. aureus isolates were fusidic acid-resistant in impetigo and 12% (5/43) in secondarily infected AD (p < 0.05). In the last year corresponding values were 24% (6/25) for impetigo and 2.2% (1/45) for AD (p < 0.01). In summary, the prospective study and the patient record review both showed higher FRSA levels in impetigo than in AD. FRSA levels were persistently low in AD. Continued restrictive use of topical fusidic acid is advised to limit an increase in FRSA levels in dermatology patients.
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| 3. |
- Fadel, Hani T, 1979, et al.
(författare)
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Profiles of Dental Caries and Periodontal Disease in Individuals With or Without Psoriasis.
- 2013
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Ingår i: Journal of periodontology. - : Wiley. - 1943-3670 .- 0022-3492. ; 84:4, s. 477-485
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Tidskriftsartikel (refereegranskat)abstract
- Background: Psoriasis is a chronic inflammatory skin disease. Studies of oral health in psoriasis patients are limited. The aim was to assess the experience and risk of caries and periodontal disease in psoriatics and non-psoriatics. Material and Methods: The material consisted of 89 individuals with mild to moderate chronic plaque psoriasis and 54 non-psoriatics, recruited at the University Hospital in Gothenburg. Psoriasis arthritis was diagnosed in 25 of the psoriatics. All participants answered questionnaires and were subjected to saliva sampling and oral radiological and clinical examinations. Two computer applications were used for illustration of oral disease risk profiles. Results: Psoriatics had lower salivary pH, fewer remaining teeth, fewer sites with probing pocket depth ≤4 mm and a lower radiographic alveolar bone level than non-psoriatics (p<0.05). Most of the differences remained significant after controlling for confounders. Differences in alveolar bone levels were no longer significant, particularly after introducing "gender" into the regression model. Similar numbers of decayed and filled teeth, sites with deep pockets, sites that bled on probing and risk profiles were observed. Individuals with psoriasis arthritis exhibited a lower stimulated salivary secretion rate than non-psoriatics (p<0.05). Conclusions: There were no differences in profiles of caries and periodontal disease experience and risk between individuals with and without psoriasis. Fewer remaining teeth were observed in psoriatics. However, the exact reason for tooth loss could not be identified. Meanwhile, the reduced salivary pH in psoriatics and salivary secretion in psoriasis arthritis individuals, may pose a risk for future caries.
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| 4. |
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| 5. |
- Flytström, Ingela, 1956
(författare)
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Different aspects of psoriasis etiology and treatment
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Psoriasis is a chronic disease where treatments are often needed throughout life. The quality of life of patients is often affected and comorbidities are common. The overall aim of this thesis was to study treatment regimes, assessments and comorbidity in psoriasis patients with the intention of finding treatment strategies that work in daily practice and improves patients’ quality of life. In Paper I, bacterial and fungal cultures were studied from intertriginous areas in psoriasis patients with and without topical steroid treatment and from healthy controls. The results show that untreated psoriatic patients were colonised by Staphylococcus aureus significantly more often than the control group but infection seemed to be unlikely. Candida was not found in any of the groups. We propose that intertriginous psoriasis could be treated with topical steroids alone. In Paper II, the effectiveness, quality of life and side-effects were compared between the treatments with methotrexate and ciclosporin. The mean PASI change from baseline at 12 weeks was 58% in the methotrexate group and 72% in the ciclosporin group, showing ciclosporin to be more effective than methotrexate. The improvement of the VAS score was also higher in the ciclosporin group. In Paper III, the sub-analysis of the assessment tools used in the second study showed that the VAS correlated with the PASI and the DLQI, except at the baseline visit for the PASI. We suggest that the VAS could be used to assess disease activity and quality of life for psoriasis patients in everyday clinical practice. In Paper IV, the experience and risk of dental caries and periodontal disease were assessed in psoriasis patients and controls, and similar profiles were observed in the two groups. Conclusion: Intertriginous psoriasis can be treated with topical steroids alone. Ciclosporin is more effective than methotrexate from a short-term perspective, although methotrexate also gives a satisfactory effect and is safer from a long-time perspective. The VAS method for assessing disease activity and quality of life in psoriasis can be recommended. In psoriasis patients, no overall increased risk for dental caries and periodontal disease was demonstrated.
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