| 1. |
- Folkesson Hellstadius, Lisa, et al.
(författare)
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How do self-reported stress and self-esteem relate to diurnal profiles of salivary alpha-amylase and cortisol in mid-adolescent girls and boys
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Salivary cortisol and alpha-amylase (sAA), that reflect hypothalamo-pituitary-adrenal axis (HPA-axis) activity and sympathetic activity within the autonomic nervous system (ANS) respectively, are biomarkers with pronounced diurnal rhythms. While research on salivary cortisol is increasing, less is known about the diurnal rhythm of sAA, particularly in adolescents. Also, the linkages between individual factors, such as self-esteem, stress and the biomarkers cortisol and sAA and their combinations remain to be investigated. Besides detailing the diurnal rhythms of salivary cortisol and sAA in 14-16 year-old girls and boys, this study investigated how self-reported stress and self-esteem relate to aggregate measures of salivary cortisol and sAA and their combinations. In addition to self-reports in questionnaires, self-administered salivary samples were collected from 47 girls and 23 boys during a school day. Results showed that girls had higher levels of morning cortisol than did boys, while there were no differences in sAA. Moreover, self-esteem and stress were associated with cortisol and sAA measures, but for girls only. Taken together, the findings suggest that both stress and self-esteem are linked to both separate and combined measures of ANS and HPA-axis activity, particularly among mid-adolescent girls.
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| 2. |
- Folkesson Hellstadius, Lisa, 1979-
(författare)
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Psychobiological functioning in mid-adolescent girls and boys : Linkages to self reported stress, self-esteem and recurrent pain
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Among adolescents, the day-to-day functioning of the hypothalamo-pituitary-adrenal-axis (HPA-axis) and of the autonomic nervous system (ANS) and their relationships with stress, subjective health complaints and psychological factors such as self-esteem, studied in naturalistic settings, have been largely unexplored. This thesis aimed to investigate the diurnal activity of the HPA-axis (Studies I & II) in terms of salivary cortisol and the ANS/SNS system (Study III) in terms of salivary alpha-amylase (sAA) in mid-adolescent girls and boys. Additionally, linkages between self-reported stress, self-esteem, recurrent pain and biomarkers were investigated. A further aim was to describe potential differences between girls and boys respectively. Study I showed that both girls and boys exhibited the typical diurnal cortisol profile with high levels in the morning that decreased throughout the day. Girls had higher total cortisol levels, while no differences emerged for measures of the cortisol increase. Study II showed no significant linkages between self-ratings of stress and cortisol. However, stress was associated with recurrent pain in girls. Study III showed that, for girls, both self-esteem and self-reported stress were related to morning levels of both cortisol and sAA, to the diurnal sAA output and to a conjoint measure of amylase over cortisol, AOC. To conclude, the findings suggest that both stress and self-esteem may be linked to different measures of ANS and HPA-axis activity, but also to measures of ANS and HPA-axis dysregulation, particularly among mid-adolescent girls.
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| 3. |
- Folkesson, Lisa, et al.
(författare)
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Economic vulnerability and adolescent health : Fragile family finances and health functioning among Swedish adolescents
- 2010
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Ingår i: International Journal of Behavioral Medicine. - : Springer. ; , s. S275-S275
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Konferensbidrag (refereegranskat)abstract
- Background: While adult health is known to vary by socioeconomic status (SES) and gender, less is known about the linkages between socioeconomic circumstances and various aspects of health in adolescents. Aim: This study set out to investigate how household financial insecurity relates to different aspects of health in adolescent girls and boys aged 10-18. Method: Data came from the Swedish Child LNU and Child-Ulf studies of 2000-2003 that include approximately 5400 children aged 10-18 who answered questions relating to health. Parents were also asked to report "cash-margin" a frequently used single-item measure asking whether parents can access 12,000 SEK in a week's time if they have to. Results: A majority, 85% of the parents were able to access 12,000 SEK in a week if necessary while 15% were unable to do so. Analyses performed separately for girls and boys showed significant main effects of cash margin on somatic health, negative functioning and positive functioning for both groups. There was no significant age x cash margin interactions. Cash margin was significantly related to stomach ache, insomnia, difficulties concentrating, irritability, short temperedness, sadness, tension/nervousness, belief in the future, endurance and happy mood in both girls and boys. Girls with no cash margin reported more headache while boys with no cash margin reported higher levels of self-assurance. No other significant relationships emerged. Discussion: While most previous studies use symptom and problem indices, this study covers multiple aspects of health functioning. To conclude, fragile family finances during adolescence as reflected in poor positive functioning and high levels of negative functioning suggest stressful living conditions that may influence academic achievement, life-choices and future health.
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| 4. |
- Folkesson, Lisa, et al.
(författare)
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Self-esteem and stress as associated with diurnal profiles of salivary alpha-amylase and cortisol in mid-adolescents
- 2014
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Ingår i: International Journal of Behavioral Medicine. - : Springer. - 1070-5503 .- 1532-7558. ; 21:1 (Suppl.), s. S116-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Salivary cortisol and alpha-amylase (sAA) that reflect hypothalamopituitary-adrenal axis (HPA-axis) activity and sympathetic activity within the autonomic nervous system (ANS) respectively, are biomarkers with pronounced diurnal rhythms. While research on salivary cortisol is increasing, little is known about the diurnal rhythm of salivary alphaamylase, particularly in adolescents. Also, the linkages between individual factors and self-reports of stress as related to HPA-axis activity and autonomic/sympathetic functioning remain to be investigated. This study set out to investigate diurnal rhythms of salivary cortisol and alpha-amylase in 14-16 year-old girls and boys. Moreover, the study investigated whether stress and self-esteem are related to aggregate salivary cortisol and alpha-amylase measures. Besides self-reports in questionnaires, self-administered salivary samples were collected from 47 girls and 23 boys during a school day. Results showed girls had higher levels of morning cortisol than did boys, while there were no differences in morning or diurnal sAA. Additionally, self-esteem and self-reported stress were associated with different measures of cortisol and sAA but for girls only. Taken together, the findings suggest that both self-reported stress and self-esteem are linked to various aspects of sympathetic ANS activity and HPA-axis activity, particularly among mid-adolescent girls.
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| 5. |
- Folkesson, Lisa, et al.
(författare)
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Single and aggregate salivary cortisol measures during two schooldays in midadolescent girls and boys
- 2014
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Ingår i: PsyCh Journal. - : Wiley. - 2046-0252 .- 2046-0260. ; 3:2, s. 121-131
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Tidskriftsartikel (refereegranskat)abstract
- Abstract: The hypothalamic-pituitary-adrenal (HPA) axis, including its regulation of cortisol, is central to bodily functioning and salivary cortisol is a commonly used biomarker that reflects the functioning of the HPA axis. However, knowledge of diurnal cortisol rhythms in healthy adolescents is limited and few studies have examined patterns in midadolescent girls and boys across single and aggregate cortisol measures. To fill this gap, the present study investigated single and aggregate cortisol measures reflecting diurnal rhythms in 14 to 16-year-old girls and boys. Self-administered salivary samples from 79 girls and 42 boys were collected during two schooldays at four timepoints: (a) immediately at awakening, (b) 30 min after waking up, (c) 60 min after waking up, and (d) at 8:00 p.m. Additionally, diary data including time of awakening, sampling times, and other potential confounders were analyzed. As for single measures, both girls and boys exhibited a typical diurnal cortisol profile with high levels in the morning that decreased throughout the day. However, girls had higher morning cortisol than did boys with significant differences at time of awakening, and at 30 and 60 min postawakening. For the aggregate measures, girls had a larger total level of cortisol in terms of cortisol awakening response (CARG), area under the curve (AUCG), and rise over run (slopeawake to last), while no differences emerged for reactivity measures. Taken together, these findings suggest differences in single and aggregate cortisol measures between midadolescent girls and boys. Such differences in diurnal cortisol between pubertal girls and boys may play a role for the differential health trajectories typically found among adult women and men.
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| 6. |
- Fransson, Emma, 1973-, et al.
(författare)
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Exploring salivary cortisol and recurrent pain in mid-adolescents living in two homes
- 2014
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Ingår i: BMC Psychology. - : Springer Science and Business Media LLC. - 2050-7283. ; 21:1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Each year, around 50.000 children in Sweden experience a separation between their parents. Joint physical custody (JPC), where the child alternates homes between the parents for about equal amount of time, has become a common living arrangement after parental separation. Children in two homes could benefit from everyday contact with both parents and access to both parents' financial resources. However, children could experience stress from being constantly moving and potentially exposed to parental conflicts. Still, studies on JPC and biological functioning related to stress, are lacking. The aim of this study was to investigate how living arrangements (intact family/JPC) relate to HPA-axis activity and recurrent pain in mid-adolescents.METHODS: Mid-adolescents (106 girls and 51 boys) provided demographic details, self-reports of recurrent pain (headache, stomachache, neck/shoulder and back pain) and salivary samples. Salivary cortisol samples were collected: 1) immediately at awakening, 2) +30 minutes, 3) +60 minutes, and 4) at 8 p.m. The cortisol awakening response (CAR) was computed using an established formula. Additionally, the diurnal decline between the waking and 8 p.m. samples was computed.RESULTS: Hierarchical multiple regressions showed that living arrangements (intact family/JPC) was not associated with morning cortisol (CAR), the diurnal cortisol decline or with recurrent pain. However, sex was a significant predictor of both cortisol measures and recurrent pain with girls exhibiting a higher cortisol awakening response and a greater diurnal decline value as well as reporting more recurrent pain than did boys.CONCLUSIONS: Living arrangements were not associated with HPA-axis activity or recurrent pain in this group of well-functioning mid-adolescents. Although this study is the first to investigate how living arrangements relate to HPA-axis functioning and additional studies are needed, the tentative findings suggest that these mid-adolescents have adapted to their living arrangements and that other factors play a more pertinent role for HPA-functioning and subjective health.
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| 7. |
- Fransson, Emma, et al.
(författare)
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Exploring salivary cortisol and recurrent pain in mid-adolescents living in two homes
- 2014
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Ingår i: International Journal of Behavioral Medicine. - : Springer Science and Business Media LLC. - 1070-5503 .- 1532-7558. ; 21, s. S23-S23
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Every year, around 50.000 children in Sweden experience a separation between their parents. Joint physical custody (JPC), where the child alternates homes between the parents for about equal amount of time, has become a common living arrangement after parental separation. Children living in two homes can benefit from everyday contact with both parents and access to both parents’ financial resources. However, children can also experience stress from constantly moving and from exposure to any parental conflict. Yet, research on JPC and stress-related biological functioning is limited. The aimof this study was to investigate how living arrangements (intact family/JPC) relate toHPA-axis activity and recurrent pain in mid-adolescents. Methods: Mid-adolescents (106 girls and 51 boys) provided demographic details, self-reports of recurrent pain (headache, stomachache, neck/shoulder and back pain) and salivary samples. Salivary cortisol samples were collected: 1) immediately at awakening, 2) +30 minutes, 3) +60 minutes, and 4) at 8 p.m. Results: Hierarchical regressions showed that living arrangements did not predict morning cortisol levels, the diurnal cortisol rhythm nor recurrent pain. However, sex was significantly associated with both morning cortisol and recurrent pain. Conclusion: Living arrangements were not linked to HPA-axis activity or recurrent pain in this group of well-functioning mid-adolescents. Although this is the first study investigating how living arrangements relate to HPA-axis functioning, which means that additional research is needed, the findings suggest that these mid-adolescents have adapted to their living arrangements and that other factors seem more pertinent for HPA-functioning and subjective health complaints.
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| 8. |
- Kurbasic, Emila, et al.
(författare)
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Changes in glycoprotein expression between primary breast tumour and synchronous lymph node metastases or asynchronous distant metastases.
- 2015
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Ingår i: Clinical Proteomics. - : Springer Science and Business Media LLC. - 1559-0275 .- 1542-6416. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- Breast cancer is a very heterogeneous disease and some patients are cured by the surgical removal of the primary tumour whilst other patients suffer from metastasis and spreading of the disease, despite adjuvant therapy. A number of prognostic and treatment predictive factors have been identified such as tumour size, oestrogen (ER) and progesterone (PgR) receptor status, human epidermal growth factor receptor type 2 (HER2) status, histological grade, Ki67 and age. Lymph node involvement is also assessed during surgery to determine if the tumour has spread which requires dissection of the axilla and adjuvant treatment. The prognostic and treatment predictive factors assessing the nature of the tumour are all routinely based on the status of the primary tumour.
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| 9. |
- Lindfors, Petra, et al.
(författare)
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Linking self-reported stress to aggregate cortisol measures and recurrent pain in midadolescent girls and boys
- 2014
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Ingår i: International Journal of Behavioral Medicine. - : Springer Science and Business Media LLC. - 1070-5503 .- 1532-7558. ; 21:S1, s. S179-S180
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Previous research has developed an 11-item self-report measure assessing activation and pressure stress among adolescents. However, the biological correlates of this measure are unclear. Considering this, the present study investigated how perceived stress relates to aggregate cortisol measures and recurrent pain in mid-adolescent girls and boys. Methods: Mid-adolescents (119 girls and 56 boys) provided self-ratings of activation and pressure stress and recurrent pain (headache, stomachache, neck/shoulder and back pain) in questionnaires. Additionally, adolescents sampled saliva during an ordinary school day: 1) immediately at awakening, 2) 30 minutes after waking up, 3) 60minutes after waking up, and 4) at 8 p.m. Aggregate cortisol measures including ground and increase measures of the area under the curve and a diurnal slope measure were computed. Hierarchical regression analyseswere performed for girls and boys respectively. Results: Activation and pressure were significantly associated with recurrent pain in girls but not in boys. However, there were no significant associations between self-ratings of stress and salivary cortisol, neither for girls nor for boys. Conclusion:While self-rated activation and pressure stress were related to recurrent pain in girls, but not in boys, neither activation nor pressure was linked to any of the aggregate cortisol measures. The differences between subjective and objective measures perhaps relate to these measures reflecting distinct and unrelated aspects of functioning. However, the findings may also result from the participants being mid-adolescents whose bodily systems are flexible and still unaffected by daily activation and pressure stress.
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| 10. |
- Lindfors, Petra, et al.
(författare)
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Perceived stress, recurrent pain, and aggregate salivary cortisol measures in mid-adolescent girls and boys
- 2017
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Ingår i: Scandinavian Journal of Psychology. - : Wiley. - 0036-5564 .- 1467-9450. ; 58:1, s. 36-42
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Tidskriftsartikel (refereegranskat)abstract
- Measures of perceived stress have been criticized for theoretical inconsistency. However, the validated pressure activation stress scale has been suggested as a theoretically sound alternative. But it is unclear how pressure and activation stress relate to objective and subjective measures including commonly used aggregate cortisol measures and health complaints respectively. Specifically, this study aimed at investigating how pressure and activation stress were related to aggregate salivary cortisol measures and recurrent pain in mid-adolescent girls and boys. Mid-adolescents (119 girls and 56 boys) provided self-reports in questionnaires on activation and pressure stress and recurrent pain (headache, stomach ache, neck/shoulder and back pain). Additionally, adolescents sampled saliva during an ordinary school day: (1) immediately at awakening; (2) 30 minutes after waking up; (3) 60 minutes after waking up, and (4) at 8 p.m. These samples were analyzed for cortisol. Hierarchical regressions showed no statistically significant associations between activation and pressure stress and cortisol, neither for girls nor for boys. However, activation and pressure stress were significantly associated with recurrent pain but only for girls. The findings may relate to subjective and objective measures reflecting distinct aspects of stress-related functioning. However, the study participants included mid-adolescents whose bodily systems are flexible and still relatively unaffected by the strain of their daily stress perceptions. To conclude, the non-significant relationships between activation and pressure stress and commonly used aggregate measures of cortisol adds to the understanding of how perceived stress may relate to physiological functioning in the daily life of adolescents when using such aggregate measures.
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