| 1. |
- Hollestelle, Antoinette, et al.
(författare)
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No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer
- 2016
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Ingår i: Gynecologic Oncology. - : Elsevier BV. - 0090-8258 .- 1095-6859. ; 141:2, s. 386-401
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Tidskriftsartikel (refereegranskat)abstract
- Objective Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3′ UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast cancer risks as well as clinical outcome associated with rs61764370. Methods Centralized genotyping and analysis were performed for 140,012 women enrolled in the Ovarian Cancer Association Consortium (15,357 ovarian cancer patients; 30,816 controls), the Breast Cancer Association Consortium (33,530 breast cancer patients; 37,640 controls), and the Consortium of Modifiers of BRCA1 and BRCA2 (14,765 BRCA1 and 7904 BRCA2 mutation carriers). Results We found no association with risk of ovarian cancer (OR = 0.99, 95% CI 0.94-1.04, p = 0.74) or breast cancer (OR = 0.98, 95% CI 0.94-1.01, p = 0.19) and results were consistent among mutation carriers (BRCA1, ovarian cancer HR = 1.09, 95% CI 0.97-1.23, p = 0.14, breast cancer HR = 1.04, 95% CI 0.97-1.12, p = 0.27; BRCA2, ovarian cancer HR = 0.89, 95% CI 0.71-1.13, p = 0.34, breast cancer HR = 1.06, 95% CI 0.94-1.19, p = 0.35). Null results were also obtained for associations with overall survival following ovarian cancer (HR = 0.94, 95% CI 0.83-1.07, p = 0.38), breast cancer (HR = 0.96, 95% CI 0.87-1.06, p = 0.38), and all other previously-reported associations. Conclusions rs61764370 is not associated with risk of ovarian or breast cancer nor with clinical outcome for patients with these cancers. Therefore, genotyping this variant has no clinical utility related to the prediction or management of these cancers.
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| 2. |
- Bousquet, Jean, et al.
(författare)
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ARIA digital anamorphosis : Digital transformation of health and care in airway diseases from research to practice
- 2021
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Ingår i: Allergy. European Journal of Allergy and Clinical Immunology. - : John Wiley & Sons. - 0105-4538 .- 1398-9995. ; 76:1, s. 168-190
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Forskningsöversikt (refereegranskat)abstract
- Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.
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| 3. |
- Bousquet, J. Jean, et al.
(författare)
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Next-generation ARIA care pathways for rhinitis and asthma : a model for multimorbid chronic diseases
- 2019
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Ingår i: Clinical and Translational Allergy. - : BMC. - 2045-7022. ; 9
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Forskningsöversikt (refereegranskat)abstract
- Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy.Main body: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Sante as a Good Practice in the field of digitally-enabled, integrated, person-centred care.Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
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| 4. |
- Mazur, Mikael, 1990, et al.
(författare)
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Continuous Fiber Sensing over Field-Deployed Metro Link using Real-Time Coherent Transceiver and DAS
- 2022
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Ingår i: 2022 European Conference on Optical Communication, ECOC 2022. - 9781957171159
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Konferensbidrag (refereegranskat)abstract
- We use an FPGA-based real-time coherent transceiver prototype with continuous μs-level state-of-polarization readouts and a commercial DAS system to perform fiber sensing. Link monitoring and active detection of link tampering is demonstrated using both systems, showing how SOP-based sensing complements DAS in metro environments.
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| 5. |
- Soares, Francisco M., et al.
(författare)
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Monolithic InP 100-Channel X 10-GHz Device for Optical Arbitrary Waveform Generation
- 2011
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Ingår i: IEEE Photonics Journal. - 1943-0655. ; 3:6, s. 975-985
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Tidskriftsartikel (refereegranskat)abstract
- We demonstrate monolithic integration of a 100-channel arrayed-waveguide grating (AWG) with 10-GHz channel spacing and 100 optically controlled Michelson-interferometer-based phase and amplitude modulators. The high-resolution AWG showed better than -15-dB crosstalk, and the modulator extinction ratio was better than 20 dB with either electrical or optical modulation control. The twin-integrated devices comprise a 50-mm diameter InP wafer with 1200 independent optoelectronic components.
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| 6. |
- Choutagunta, Karthik, et al.
(författare)
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Modal Dynamics in Spatially Multiplexed Links
- 2019
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Ingår i: Optics InfoBase Conference Papers. - Washington, D.C. : OSA. - 2162-2701.
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Konferensbidrag (refereegranskat)abstract
- We investigate the vibration sensitivity of spatially multiplexed links by measuring the mode-coupling dynamics of a four-core coupled-core fiber and a reference single-mode fiber. We show that the speed of dynamics increases with mode count.
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| 7. |
- Fontaine, Nicolas K., et al.
(författare)
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Digital turbulence compensation of free space optical link with multimode optical amplifier
- 2019
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Ingår i: IET Conference Publications. - : Institution of Engineering and Technology. ; 2019:CP765
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Konferensbidrag (refereegranskat)abstract
- We demonstrate digital turbulence compensation using a 12-spatial mode digital coherent receiver with a multimode preamplifier that provides a 6-dB sensitivity improvement. This combination acts similarly to ideal lossless adaptive optics. Coherent superposition of 12 spatial-modes reduced median BER from 0.1 to 1×10-5 compared to traditional single-mode detection.
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| 8. |
- Furdek Prekratic, Marija, 1985, et al.
(författare)
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Guest Editorial Photonic Networks and Devices
- 2019
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Ingår i: Journal of Lightwave Technology. - 0733-8724 .- 1558-2213. ; 37:16, s. 3872-3874
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 9. |
- Huang, Yetian, et al.
(författare)
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Free-Space Optics Communications Employing Elliptical-Aperture Multimode Diversity Reception Under Anisotropic Turbulence
- 2022
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Ingår i: Journal of Lightwave Technology. - 0733-8724 .- 1558-2213. ; 40:5, s. 1502-1508
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Tidskriftsartikel (refereegranskat)abstract
- We experimentally demonstrate an elliptical-aperture multimode diversity receiver to mitigate the impairment from anisotropic turbulence, which is emulated by employing an electrically-controlled heater. The anisotropy gradually decreases as the flow-level of the introduced airflow from fans increases. In contrast to circular-aperture reception, the elliptical-aperture multimode diversity receiver can effectively resist beam wander under anisotropic turbulence, reducing outage probability from 14.63% to 0.38% for detecting a dual-polarization 30-Gbaud QPSK signal. Without the aid of an adaptive optics system, this work demonstrates the feasibility of realizing an anisotropic-turbulence-resistant FSO link using multimode and multi-aperture diversity reception employing digital coherent combining techniques.
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| 10. |
- Huang, Yetian, et al.
(författare)
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Optical Broadcasting Employing Incoherent And Low-Coherence Spatial Modes for Bi-Directional Optical Wireless Communications
- 2021
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Ingår i: Journal of Lightwave Technology. - 0733-8724 .- 1558-2213. ; 39:3, s. 833-838
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Tidskriftsartikel (refereegranskat)abstract
- We introduce recently developed space division multiplexing (SDM)-associated technologies into optical wireless communications (OWC) and propose to use incoherent and low-coherence spatial modes to realize optical broadcasting with reliable performance by mitigating coherent interference. We experimentally demonstrate reconfigurable optical beam steering using a programmable multi-plane light conversion (MPLC)-based mode multiplexer (MMUX) and realize point-to-multi-point optical wireless communications with low-loss up-link optical beam combining and reach extension using multimode fiber (MMF). Both incoherent and low-coherence spatial modes can be generated employing the cost-efficient components such as multimode vertical cavity surface emitting laser (MM-VCSEL) and broadband amplified spontaneous emission (ASE) noise source.
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