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Sökning: WFRF:(Forde I)

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  • Chakroborty, Anand, et al. (författare)
  • Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica
  • 2023
  • Ingår i: Pharmaceutics. - : MDPI AG. - 1999-4923. ; 15:7
  • Tidskriftsartikel (refereegranskat)abstract
    • Infection with Fasciola hepatica (liver fluke) causes fasciolosis (or fascioliasis) and poses a considerable economic as well as welfare burden to both the agricultural and animal health sectors. Here, we explore the ex vivo anthelmintic potential of synthetic derivatives of hederagenin, isolated in bulk from Hedera helix. Thirty-six compounds were initially screened against F. hepatica newly excysted juveniles (NEJs) of the Italian strain. Eleven of these compounds were active against NEJs and were selected for further study, using adult F. hepatica derived from a local abattoir (provenance unknown). From these eleven compounds, six demonstrated activity and were further assessed against immature liver flukes of the Italian strain. Subsequently, the most active compounds (n = 5) were further evaluated in ex vivo dose response experiments against adult Italian strain liver flukes. Overall, MC042 was identified as the most active molecule and the EC50 obtained from immature and adult liver fluke assays (at 24 h post co-culture) are estimated as 1.07 & mu;M and 13.02 & mu;M, respectively. When compared to the in vitro cytotoxicity of MDBK bovine cell line, MC042 demonstrated the highest anthelmintic selectivity (44.37 for immature and 3.64 for adult flukes). These data indicate that modified hederagenins display properties suitable for further investigations as candidate flukicides.
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  • Stuart, M., et al. (författare)
  • Reflections on work and employment into the 21st century : between equal rights, force decides
  • 2013
  • Ingår i: Work, Employment and Society. - : Sage Publications. - 0950-0170 .- 1469-8722. ; 27:3, s. 379-395
  • Tidskriftsartikel (refereegranskat)abstract
    • In this introductory article, the editors of Work, Employment and Society reflect on the journal's body of published work and present the main contributions of the 25-year anniversary issue. As a journal of record WES is now well established and offers extensive conceptual insights into, and empirical analysis of, contemporary trends and experiences of work, employment and unemployment. Yet academic scholarship should also aspire to comment, critique and counter; four themes are elaborated, with reference to the issue's contributions, to illustrate this: labour market change; work in the service sector; post-Fordism, disconnection and financialization; and moral economy and counter movements.
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