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| 2. |
- Andersson, John, et al.
(författare)
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Pm2.5 and dementia in a low exposure setting : the influence of odor identification ability and APOE
- 2023
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Ingår i: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 92:2, s. 679-689
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Tidskriftsartikel (refereegranskat)abstract
- Background: Growing evidence show that long term exposure to air pollution increases the risk of dementia.Objective: The aim of this study was to investigate associations between PM2.5 exposure and dementia in a low exposure area, and to investigate the role of olfaction and the APOE ε4 allele in these associations.Methods: Data were drawn from the Betula project, a longitudinal study on aging, memory, and dementia in Sweden. Odor identification ability was assessed using the Scandinavian Odor Identification Test (SOIT). Annual mean PM2.5 concentrations were obtained from a dispersion-model and matched at the participants’ residential address. Proportional hazard regression was used to calculate hazard ratios.Results: Of 1,846 participants, 348 developed dementia during the 21-year follow-up period. The average annual mean PM2.5 exposure at baseline was 6.77 µg/m3, which is 1.77 µg/m3 above the WHO definition of clean air. In a fully adjusted model (adjusted for age, sex, APOE, SOIT, cardiovascular diseases and risk factors, and education) each 1 µg/m3 difference in annual mean PM2.5-concentration was associated with a hazard ratio of 1.23 for dementia (95% CI: 1.01–1.50). Analyses stratified by APOE status (ε4 carriers versus non-carriers), and odor identification ability (high versus low), showed associations only for ε4 carriers, and for low performance on odor identification ability.Conclusion: PM2.5 was associated with an increased risk of dementia in this low pollution setting. The associations between PM2.5 and dementia seemed stronger in APOE carriers and those with below average odor identification ability.
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| 3. |
- Andersson, John, et al.
(författare)
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PM2.5 and Dementia in a Low Exposure Setting : The Influence of Odor Identification Ability and APOE
- 2023
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Ingår i: Journal of Alzheimer's disease : JAD. - 1387-2877. ; 92:2, s. 679-689
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Growing evidence show that long term exposure to air pollution increases the risk of dementia. OBJECTIVE: The aim of this study was to investigate associations between PM2.5 exposure and dementia in a low exposure area, and to investigate the role of olfaction and the APOE ɛ4 allele in these associations. METHODS: Data were drawn from the Betula project, a longitudinal study on aging, memory, and dementia in Sweden. Odor identification ability was assessed using the Scandinavian Odor Identification Test (SOIT). Annual mean PM2.5 concentrations were obtained from a dispersion-model and matched at the participants' residential address. Proportional hazard regression was used to calculate hazard ratios. RESULTS: Of 1,846 participants, 348 developed dementia during the 21-year follow-up period. The average annual mean PM2.5 exposure at baseline was 6.77μg/m3, which is 1.77μg/m3 above the WHO definition of clean air. In a fully adjusted model (adjusted for age, sex, APOE, SOIT, cardiovascular diseases and risk factors, and education) each 1μg/m3 difference in annual mean PM2.5-concentration was associated with a hazard ratio of 1.23 for dementia (95% CI: 1.01-1.50). Analyses stratified by APOE status (ɛ4 carriers versus non-carriers), and odor identification ability (high versus low), showed associations only for ɛ4 carriers, and for low performance on odor identification ability. CONCLUSION: PM2.5 was associated with an increased risk of dementia in this low pollution setting. The associations between PM2.5 and dementia seemed stronger in APOE carriers and those with below average odor identification ability.
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| 4. |
- Andersson, John, et al.
(författare)
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Road traffic noise, air pollution, and risk of dementia : results from the Betula project
- 2018
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Ingår i: Environmental Research. - : Elsevier. - 0013-9351 .- 1096-0953. ; 166, s. 334-339
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Tidskriftsartikel (refereegranskat)abstract
- Background: There is growing evidence for a negative impact of traffic-related air pollution on risk of dementia. However, the contribution of noise exposure to this association has been rarely examined.Objective: We aimed to investigate the individual and combined effect of noise and air pollution on risk of dementia.Methods: Data on dementia incidence over a 15 year period was obtained from the Betula project, a longitudinal study on health and ageing. Estimates of annual mean levels of nitrogen oxides (NOx) at the participants’ residential address were obtained using a land-use regression model. Modelled data provided road traffic noise levels (Leq. 24 h) at the participants’ residential address at baseline. Cox proportional hazard regression was used to calculate hazard ratios (HR).Results: Of 1721 participants at baseline, 302 developed dementia during the follow up period. Exposure to noise levels (Leq. 24 h) > 55 dB had no significant effect on dementia risk (HR 0.95; CI: 0.57, 1.57). Residing in the two highest quartiles of NOx exposure was associated with an increased risk of dementia. The risk associated with NOx was not modified by adjusting for noise. Moreover, we found no significant interaction effects between NOx and road traffic noise on dementia risk.Conclusion: We found no evidence that exposure to road traffic noise, either independently or in combination with traffic air pollution, was associated with risk of dementia in our study area. Our results suggest that pollution should be considered the main component in the association between traffic related exposures and dementia.
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| 5. |
- Andréasson, Maia, 1960, et al.
(författare)
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Swedish CLARIN activities
- 2009
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Ingår i: Proceedings of the Nodalida 2009 workshop on CLARIN activities in the Nordic countries. NEALT Proceedings Series. - 1736-6305. ; 5, s. 1-5
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Konferensbidrag (refereegranskat)
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| 6. |
- Andréasson, Maia, et al.
(författare)
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Swedish CLARIN Activities
- 2009
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Ingår i: Proceedings of the NODALIDA 2009 workshop Nordic Perspectives on the CLARIN Infrastructure of Language Resources. - : Northern European Association for Language Technology (NEALT). ; , s. 1-5
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Konferensbidrag (refereegranskat)abstract
- Although Sweden has yet to allocate funds specifically intended for CLARIN activities, there are some ongoing activities which are directly relevant to CLARIN, and which are explicitly linked to CLARIN. These activities have been funded by the Committee for Research Infrastructures and its subcommittee DISC (Database Infrastructure Committee) of the Swedish Research Council.
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| 7. |
- Axsäter, Sven, et al.
(författare)
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Approximating general multi-echelon inventory systems by Poisson models
- 1994
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Ingår i: International Journal of Production Economics. - : Elsevier BV. - 0925-5273 .- 1873-7579. ; 35:1-3, s. 201-206
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Tidskriftsartikel (refereegranskat)abstract
- We consider a continuous review two-level inventory system with a central warehouse and a number of retailers. The demand processes at the retailers are different compound Poisson processes. We present and evaluate an approximate optimization technique, where the real demand is replaced by "equivalent" Poisson demand such that the ratio between mean and standard deviation is the same as for the real distribution. The solution of the Poisson model is then scaled back to the original problem.
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| 8. |
- Brander, Pär, et al.
(författare)
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Cyclic lot scheduling with sequence-dependent set-ups : a heuristic for disassembly processes
- 2005
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Ingår i: International Journal of Production Research. - : Informa UK Limited. - 0020-7543 .- 1366-588X. ; 43:2, s. 295-310
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Tidskriftsartikel (refereegranskat)abstract
- The importance of material and product recovery is steadily increasing, mainly due to customer expectations and take-back obligations. Disassembly is a major operation in material and product recovery, since returned products are often disassembled to separate materials and components. The paper considers the problem of scheduling several items on a single disassembly facility. It develops a cyclic lot-scheduling heuristic for disassembly processes with sequence- dependent set-ups, resulting in disassembly frequencies for the items. Additionally, the way the problem is formulated allows calculation of the profitable use of the facility. The disassembly frequencies and the profitable use of the facility are used to create a cyclic schedule.
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| 9. |
- Brander, Pär, et al.
(författare)
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Cyclic lot scheduling with stochastic demands : a heuristic with safety stocks
- 2004
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Ingår i: Preprints. ; , s. 69-89
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Konferensbidrag (refereegranskat)abstract
- This paper considers the problem of scheduling the production of multiple items, each with random demand, on a single facility. We show how the variance in demand during lead time can be estimated and present a model for determination of safety stocks and order-up-to levels for a fixed cyclic sequence, both with and without idle time. For systems with idle time, we present a control model to make the decision to produce next item in sequence or idle the facility. The performance of the model is tested in a simulation study.
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| 10. |
- Brander, Pär, et al.
(författare)
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Determination of safety stocks for cyclic schedules with stochastic demands
- 2006
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Ingår i: International Journal of Production Economics. - : Elsevier BV. - 0925-5273 .- 1873-7579. ; 104:2, s. 271-295
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Tidskriftsartikel (refereegranskat)abstract
- This paper considers the problem of scheduling the production of multiple items, each with random demand, on a single facility. We show how the variance in demand during lead time can be estimated and present a model for determination of safety stocks and order-up-to levels for a fixed cyclic sequence, both with and without idle time. For systems with idle time, we present a control model to make the decision to produce next item in sequence or idle the facility. The performance of the model is tested in a simulation study.
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