| 1. |
- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 2. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 3. |
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| 4. |
- Forsey, R.J., et al.
(författare)
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Plasma cytokine profiles in elderly humans
- 2003
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Ingår i: Mechanisms of Ageing and Development. - 0047-6374 .- 1872-6216. ; 124:4, s. 487-493
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- It is known that as we age, immune dysregulation often occurs, leading to failing health, and increased susceptibility to a number of different diseases. In this study we have investigated plasma cytokine profiles in order to identify immune markers of ageing. Plasma samples were obtained from 138 participants of the Swedish longitudinal NONA study (aged 86, 90 and 94 years) and 18 healthy Swedish volunteers (aged between 32 and 59 years). Our results show significantly increased levels of the pro-inflammatory cytokine interleukin-6 (P<0.0001) and soluble intercellular adhesion molecule-1 (P<0.0001) in the elderly group. The anti-inflammatory cytokine interleukin-10 did not alter with age whereas active (naturally processed) transforming growth factor-ß levels were significantly (P<0.0001) increased in the elderly group. No difference was observed between males and females. These data suggest that there are measurable changes in cytokine profiles with ageing with increased levels of potentially harmful molecules, which may contribute to immune alterations and declining health in the elderly population. © 2003 Elsevier Science Ireland Ltd. All rights reserved.
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| 5. |
- Simm, T. H., et al.
(författare)
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The τ-plot, a multicomponent 1-D pole figure plot, to quantify the heterogeneity of plastic deformation
- 2020
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Ingår i: Materials Characterization. - : Elsevier Inc.. - 1044-5803 .- 1873-4189. ; 160
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Tidskriftsartikel (refereegranskat)abstract
- An approach is presented that allows multi-scale characterisations of heterogeneous deformation in crystalline materials by employing a range of characterisation techniques including: electron backscatter diffraction, digital image correlation and neutron diffraction powder measurements. The approach will be used to obtain critical information about the variations in parameters that characterise the deformed state in different crystallographic orientation texture components of a sample in a statistically significant way. These parameters include lattice strains, texture evolution, peak broadening, dislocation density, planar faults, phase changes and surface strain. This approach allows verification of models of plastic deformation to provide a more detailed view of plastic deformation heterogeneity at multiple length scales than obtained by other characterisation approaches. The approach demonstrated here is applied to two stainless steel alloys; an alloy that exhibits phase transformation during deformation and an alloy that remains the same phase all through deformation process.
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| 6. |
- Wikby, A, et al.
(författare)
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An immune risk phenotype, cognitive impairment and survival in very late life: The impact of alosta-tic load in Swedish Octo- and Nongenarian humans
- 2005
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Ingår i: Journal Gerontology: Biological Science. ; , s. 556-565
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Tidskriftsartikel (refereegranskat)abstract
- In the previous OCTO longitudinal study, we identified an immune risk pheno-type (IRP) of high CD8 and low CD4 numbers and poor proliferative response. We also demonstrated that cognitive impairment constitutes a major predictor of nonsurvival. In the present NONA longitudinal study, we simultaneously exam-ine in a model of allostatic load IRP and compromised cognition in 4-year survival in a population-based sample (n = 138, 86-94 years). Immune system measure-ments consisted of determinations of T-cell subsets, plasma interleukin 6 and cy-tomegalovirus and Epstein-Barr virus serology. Interleukin 2 responsiveness to concanavalin A, using data from the previous OCTO (octogenarians) immune study, hereafter OCTO immune, was also examined. Cognitive status was rated using a battery of neuropsychological tests. Logistic regression indicated that the IRP and cognitive impairment together predicted 58% of observed deaths. IRP was associated with late differentiated CD8+CD28-CD27- cells (p < .001), de-creased interleukin 2 responsiveness (p < .05) and persistent viral infection (p < .01). Cognitive impairment was associated with increased plasma interleukin 6 (p < .001). IRP individuals with cognitive impairment were all deceased at the fol-low-up, indicating an allostatic overload.
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| 7. |
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| 8. |
- Wikby, A, et al.
(författare)
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The immune risk phenotype is associated with Il-6 in the terminal decline stage: Findings from the Swedish NONA immune longitudinal study of very late life functioning
- 2006
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Ingår i: Mechanisms Ageing and Development. - : Elsevier. ; 127:8, s. 695-704
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Tidskriftsartikel (refereegranskat)abstract
- In the present NONA immune longitudinal study, we further examine the previously identi-fied T cell immune risk phenotype (IRP), relative inflammatory activity, morbidity and 2-year mortality in very old individuals >90 years. T-cell subsets as well as the inflammatory mark-ers IL-6, IL-10, C-reactive protein, transthyretin and albumin were evaluated. IRP and low-grade inflammation predicted 57% of observed deaths and 97% of survival over 2 years, and was not significantly affected by individuals' health status, suggesting that the physiological ageing processes of T-cell immunosenescence and low-grade inflammation are of primary importance in late life survival. IRP non-survivors showed only a minor inflammatory activity at baseline, but had in contrast to survivors developed increased activity at follow-up. The re-sults suggest a sequence of stages for IRP individuals that begin with acquisition of CMV in-fection in earlier life, followed by generation of CD8+CD28- cells to control persistent CMV infection and eventually the development of an IRP. Intriguingly, we also found that rare in-dividuals moved out of the IRP category by a process of immune suppression, including in-creases in IL-6 and IL-10 and decreases in the number of CD3+CD8+CD28- cells. The fur-ther characterisation of these exceptional individuals may allow insight into remedial ap-proaches for those who remain in the IRP category until death
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