SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Forstner O.) "

Sökning: WFRF:(Forstner O.)

  • Resultat 1-10 av 76
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  •  
3.
  •  
4.
  • Mullins, N., et al. (författare)
  • Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
  • 2021
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 53, s. 817-829
  • Tidskriftsartikel (refereegranskat)abstract
    • Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci. Bipolar disorder risk alleles were enriched in genes in synaptic signaling pathways and brain-expressed genes, particularly those with high specificity of expression in neurons of the prefrontal cortex and hippocampus. Significant signal enrichment was found in genes encoding targets of antipsychotics, calcium channel blockers, antiepileptics and anesthetics. Integrating expression quantitative trait locus data implicated 15 genes robustly linked to bipolar disorder via gene expression, encoding druggable targets such as HTR6, MCHR1, DCLK3 and FURIN. Analyses of bipolar disorder subtypes indicated high but imperfect genetic correlation between bipolar disorder type I and II and identified additional associated loci. Together, these results advance our understanding of the biological etiology of bipolar disorder, identify novel therapeutic leads and prioritize genes for functional follow-up studies. Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.
  •  
5.
  • Niedermaier, O., et al. (författare)
  • "Safe" Coulomb excitation of Mg-30
  • 2005
  • Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 94:17, s. 172501 (artno)-
  • Tidskriftsartikel (refereegranskat)abstract
    • We report on the first radioactive beam experiment performed at the recently commissioned REX-ISOLDE facility at CERN in conjunction with the highly efficient γ spectrometer MINIBALL. Using Mg-30 ions accelerated to an energy of 2.25 MeV/u together with a thin Ni-nat target, Coulomb excitation of the first excited 2(+) states of the projectile and target nuclei well below the Coulomb barrier was observed. From the measured relative deexcitation γ-ray yields the B(E2;0(gs)(+)→ 2(1)(+)) value of Mg-30 was determined to be 241(31)e(2) fm(4). Our result is lower than values obtained at projectile fragmentation facilities using the intermediate-energy Coulomb excitation method, and confirms the theoretical conjecture that the neutron-rich magnesium isotope Mg-30 resides outside the "island of inversion."
  •  
6.
  • Niedermaier, O., et al. (författare)
  • The neutron-rich Mg isotopes: first results from MINIBALL at REX-ISOLDE
  • 2005
  • Ingår i: Nuclear Physics A. - : Elsevier BV. - 0375-9474. ; 752, s. 273-273
  • Tidskriftsartikel (refereegranskat)abstract
    • We report on the first radioactive beam experiment performed at the recently commissioned REX-ISOLDE facility at CERN in conjunction with the highly efficient γ spectrometer MINIBALL. Using Mg-30 ions accelerated to an energy of 2.25 MeV/u together with a thin Ni-nat target, Coulomb excitation of the first excited 2(+) states of the projectile and target nuclei well below the Coulomb barrier was observed. From the measured relative deexcitation γ-ray yields the B(E2;0(gs)(+)→ 2(1)(+)) value of Mg-30 was determined to be 241(31)e(2) fm(4). Our result is lower than values obtained at projectile fragmentation facilities using the intermediate-energy Coulomb excitation method, and confirms the theoretical conjecture that the neutron-rich magnesium isotope Mg-30 resides outside the "island of inversion."
  •  
7.
  • Scheit, H., et al. (författare)
  • Coulomb excitation of neutron-rich beams at REX-ISOLDE
  • 2005
  • Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-601X .- 1434-6001. ; 25:Suppl. 1, s. 397-402
  • Konferensbidrag (refereegranskat)abstract
    • After the successful commissioning of the radioactive beam experiment at ISOLDE (REX-ISOLDE) - an accelerator for exotic nuclei produced by ISOLDE - in 2002 and the promotion to a CERN user facility in 2003, first physics experiments using these beams were performed. Initial experiments focused on the region of deformation in the vicinity of the neutron-rich Na and Mg isotopes. Preliminary results on the neutron-rich Na and Mg isotopes show the high potential and physics opportunities offered by the exotic isotope accelerator REX in conjunction with the modern Germanium gamma spectrometer MINIBALL.
  •  
8.
  •  
9.
  •  
10.
  • Bryois, J., et al. (författare)
  • Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease
  • 2020
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 52:5, s. 482-493
  • Tidskriftsartikel (refereegranskat)abstract
    • Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson’s disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson’s disease. © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 76
Typ av publikation
tidskriftsartikel (68)
konferensbidrag (8)
Typ av innehåll
refereegranskat (72)
övrigt vetenskapligt/konstnärligt (4)
Författare/redaktör
Cichon, S (35)
Herms, S. (35)
Rietschel, M (31)
Degenhardt, F (31)
Ripke, S (31)
Hoffmann, P (29)
visa fler...
Muller-Myhsok, B (28)
Forstner, AJ (28)
Breen, G (26)
Streit, F (26)
Werge, T (25)
Mattheisen, M (25)
Mors, O (25)
Metspalu, A (25)
Esko, T (24)
Stefansson, K (24)
Frank, J (24)
Craddock, N (23)
Martin, NG (23)
Forstner, O. (23)
Grove, J (22)
Posthuma, D (22)
Lucae, S (21)
Strohmaier, J (21)
Stefansson, H. (21)
Dannlowski, U (21)
Steinberg, S (20)
Montgomery, GW (20)
Smoller, JW (20)
Wray, NR (20)
Schulze, TG (20)
Gill, M. (20)
McGuffin, P (20)
Owen, MJ (20)
Rivera, M (20)
Baune, BT (19)
Yang, J. (19)
Milaneschi, Y (19)
Nothen, MM (19)
Medland, SE (19)
Levinson, DF (19)
Nordentoft, M (19)
Perlis, RH (19)
Treutlein, J (19)
Witt, SH (19)
Hayward, C. (19)
Escott-Price, V (19)
Maier, W (19)
Milani, L (19)
Sigurdsson, E (19)
visa färre...
Lärosäte
Karolinska Institutet (47)
Göteborgs universitet (30)
Chalmers tekniska högskola (16)
Umeå universitet (9)
Uppsala universitet (6)
Lunds universitet (6)
visa fler...
Stockholms universitet (2)
Kungliga Tekniska Högskolan (1)
Örebro universitet (1)
Linköpings universitet (1)
Handelshögskolan i Stockholm (1)
RISE (1)
visa färre...
Språk
Engelska (76)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (29)
Medicin och hälsovetenskap (25)
Teknik (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy