| 1. |
- Allanach, Benjamin C., et al.
(författare)
-
Simple and statistically sound strategies for analysing physical theories
- 2022
-
Ingår i: Reports on progress in physics (Print). - : Institute of Physics Publishing (IOPP). - 0034-4885 .- 1361-6633. ; 85:5
-
Forskningsöversikt (refereegranskat)abstract
- Physical theories that depend on many parameters or are tested against data from many different experiments pose unique challenges to statistical inference. Many models in particle physics, astrophysics and cosmology fall into one or both of these categories. These issues are often sidestepped with statistically unsound ad hoc methods, involving intersection of parameter intervals estimated by multiple experiments, and random or grid sampling of model parameters. Whilst these methods are easy to apply, they exhibit pathologies even in low-dimensional parameter spaces, and quickly become problematic to use and interpret in higher dimensions. In this article we give clear guidance for going beyond these procedures, suggesting where possible simple methods for performing statistically sound inference, and recommendations of readily-available software tools and standards that can assist in doing so. Our aim is to provide any physicists lacking comprehensive statistical training with recommendations for reaching correct scientific conclusions, with only a modest increase in analysis burden. Our examples can be reproduced with the code publicly available at Zenodo.
|
|
| 2. |
- Athron, Peter, et al.
(författare)
-
Bayesian analysis and naturalness of (Next-to-)Minimal Supersymmetric Models
- 2017
-
Ingår i: Journal of High Energy Physics (JHEP). - 1126-6708 .- 1029-8479. ; :10
-
Tidskriftsartikel (refereegranskat)abstract
- The Higgs boson discovery stirred interest in next-to-minimal supersymmetric models, due to the apparent fine-tuning required to accommodate it in minimal theories. To assess their naturalness, we compare fine-tuning in a Z(3) conserving semi-constrained Next-to-Minimal Supersymmetric Standard Model (NMSSM) to the constrained MSSM (CMSSM). We contrast popular fine-tuning measures with naturalness priors, which automatically appear in statistical measures of the plausibility that a given model reproduces the weak scale. Our comparison shows that naturalness priors provide valuable insight into the hierarchy problem and rigorously ground naturalness in Bayesian statistics. For the CMSSM and semi-constrained NMSSM we demonstrate qualitative agreement between naturalness priors and popular fine tuning measures. Thus, we give a clear plausibility argument that favours relatively light superpartners.
|
|
| 3. |
- Athron, Peter, et al.
(författare)
-
Global analyses of Higgs portal singlet dark matter models using GAMBIT
- 2019
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 79:1
-
Tidskriftsartikel (refereegranskat)abstract
- We present global analyses of effective Higgs portal dark matter models in the frequentist and Bayesian statistical frameworks. Complementing earlier studies of the scalar Higgs portal, we use GAMBIT to determine the preferred mass and coupling ranges for models with vector, Majorana and Dirac fermion dark matter. We also assess the relative plausibility of all four models using Bayesian model comparison. Our analysis includes up-to-date likelihood functions for the dark matter relic density, invisible Higgs decays, and direct and indirect searches for weakly-interacting dark matter including the latest XENON1T data. We also account for important uncertainties arising from the local density and velocity distribution of dark matter, nuclear matrix elements relevant to direct detection, and Standard Model masses and couplings. In all Higgs portal models, we find parameter regions that can explain all of dark matter and give a good fit to all data. The case of vector dark matter requires the most tuning and is therefore slightly disfavoured from a Bayesian point of view. In the case of fermionic dark matter, we find a strong preference for including a CP-violating phase that allows suppression of constraints from direct detection experiments, with odds in favour of CP violation of the order of 100:1. Finally, we present DDCalc2.0.0, a tool for calculating direct detection observables and likelihoods for arbitrary non-relativistic effective operators.
|
|
| 4. |
- Cranmer, Kyle, et al.
(författare)
-
Publishing statistical models : Getting the most out of particle physics experiments
- 2022
-
Ingår i: SciPost Physics. - 2542-4653. ; 12:1
-
Tidskriftsartikel (refereegranskat)abstract
- The statistical models used to derive the results of experimental analyses are of incredible scientific value and are essential information for analysis preservation and reuse. In this paper, we make the scientific case for systematically publishing the full statistical models and discuss the technical developments that make this practical. By means of a variety of physics cases - including parton distribution functions, Higgs boson measurements, effective field theory interpretations, direct searches for new physics, heavy flavor physics, direct dark matter detection, world averages, and beyond the Standard Model global fits - we illustrate how detailed information on the statistical modelling can enhance the short- and long-term impact of experimental results.
|
|
| 5. |
- Jeverica, Samo, et al.
(författare)
-
High in vitro activity of a novel dual bacterial topoisomerase inhibitor of the ATPase activities of GyrB and ParE (VT12-008911) against Neisseria gonorrhoeae isolates with various high-level antimicrobial resistance and multidrug resistance
- 2014
-
Ingår i: Journal of Antimicrobial Chemotherapy. - : Oxford University Press. - 0305-7453 .- 1460-2091. ; 69:7, s. 1866-1872
-
Tidskriftsartikel (refereegranskat)abstract
- Clinical resistance to the currently recommended extended-spectrum cephalosporins (ESCs), the last remaining options for empirical antimicrobial monotherapy of gonorrhoea globally, has been reported. New antimicrobials are essential to avoid the emergence of untreatable gonorrhoea. We have investigated the in vitro activity of a novel dual bacterial topoisomerase inhibitor of the ATPase activities of GyrB and ParE (Vertex aminobenzimidazole VT12-008911), compared with antimicrobials currently or previously recommended for gonorrhoea treatment.MICs were determined using agar dilution (VT12-008911) or Etest (seven antimicrobials) for international reference strains (naEuroS=aEuroS28) and clinical Neisseria gonorrhoeae isolates (naEuroS=aEuroS220). The latter included three extensively drug-resistant isolates with high-level ceftriaxone resistance, additional isolates with clinical ESC resistance and a high number of isolates with ciprofloxacin resistance and multidrug resistance.The MIC50, MIC90 and MIC range of VT12-008911 were 0.064, 0.125 and a parts per thousand currency sign0.002-0.25 mg/L, respectively. One-hundred and seventy (69%) isolates were ciprofloxacin resistant; however, only 54 of those isolates had a VT12-008911 MIC > 0.064 mg/L (47 and 7 with MICaEuroS=aEuroS0.125 mg/L and MICaEuroS=aEuroS0.25 mg/L, respectively). The in vitro activity of VT12-008911 was superior to that of ciprofloxacin and all additional antimicrobials investigated. Time-kill curve analysis showed that VT12-008911 exhibited potent time-dependent bactericidal activity, at or very close to the MIC, against N. gonorrhoeae.In vitro results suggest that VT12-008911 might be an effective treatment option for gonorrhoea. However, it will be important to detail the pharmacokinetics/pharmacodynamics, toxicity, selection and mechanisms of VT12-008911 resistance in N. gonorrhoeae and, finally, to perform well-designed in vivo randomized clinical trials.
|
|
