| 1. |
- Fröhling, Robert, et al.
(författare)
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Developing hollow wear limits based on field experience and numerical simulations
- 2006
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Ingår i: Proceedings 7th International Conference on Contact Mechanics and Wear of Rail/Wheel Systems. ; , s. 9 pp-
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Konferensbidrag (refereegranskat)abstract
- The current paper deals with the influence of hollow wheels on the risk for surface initiated rolling contact fatigue. To this end, the problem is introduced and field experiences are outlined. The problem is then analyzed more in detail through numerical simulations of bogie curving. Quasi-static simulations featuring several hollowed profiles are carried out to give a first rough estimation of the severity. Simulations of the dynamic curving behaviour are carried out for a selected case to provide a more detailed image of the detrimental nature of wear hollowing. These are complimented by a FE-simulation for a detailed study of the contact configuration. Finally, the results are discussed and conclusions are drawn. In particular it is shown how high rolling contact fatigue impact is associated with high lateral forces and a narrow contact patch. It is also seen to be likely that quasi-static simulations underestimate fatigue impact and that the current practice of characterizing hollow wear by the wear depth is flawed.
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| 2. |
- Fröhling, Robert, et al.
(författare)
-
Guest editorial of Special Issue on High Tech in Heavy Haul
- 2009
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Ingår i: Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid Transit. - : SAGE Publications. - 0954-4097 .- 2041-3017. ; 223, s. i-ii
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Fröhling, Robert, et al.
(författare)
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Preface: Special issue on heavy haul
- 2019
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Ingår i: Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid Transit. - : SAGE Publications. - 0954-4097 .- 2041-3017. ; 233:6, s. 595-595
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Fröhling, Robert, et al.
(författare)
-
The detrimental effects of hollow wear – field experiences and numerical simulations
- 2008
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Ingår i: Wear. - : Elsevier BV. - 0043-1648. ; 265:9-10, s. 1283-1291
-
Tidskriftsartikel (refereegranskat)abstract
- The current paper deals with the influence of hollow wheels on the risk for surface initiated rolling contact fatigue. To this end, the problem is introduced and field experiences are outlined. The problem is then analyzed more in detail through numerical simulations of bogie curving. Quasi-static simulations featuring several hollowed profiles are carried out to give a first rough estimation of the severity. Simulations of the dynamic curving behaviour are carried out for a selected case to provide a more detailed image of the detrimental nature of wear hollowing. These are complemented by a FE-simulation for a detailed study of the contact configuration. Finally, the results are discussed and conclusions are drawn. In particular it is shown how high rolling contact fatigue impact is associated with high lateral forces and a narrow contact patch. It is also seen to be likely that quasi-static simulations underestimate fatigue impact and that the current practice of characterizing hollow wear by the wear depth is flawed.
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| 5. |
- Schöpf, Julia, et al.
(författare)
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Multi-omic and functional analysis for classification and treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions
- 2024
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Ingår i: Nature Communications. - 2041-1723. ; 15, s. 1-17
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Tidskriftsartikel (refereegranskat)abstract
- Linking clinical multi-omics with mechanistic studies may improve the understanding of rare cancers. We leverage two precision oncology programs to investigate rhabdomyosarcoma with FUS/EWSR1-TFCP2 fusions, an orphan malignancy without effective therapies. All tumors exhibit outlier ALK expression, partly accompanied by intragenic deletions and aberrant splicing resulting in ALK variants that are oncogenic and sensitive to ALK inhibitors. Additionally, recurrent CKDN2A/MTAP co-deletions provide a rationale for PRMT5-targeted therapies. Functional studies show that FUS-TFCP2 blocks myogenic differentiation, induces transcription of ALK and truncated TERT, and inhibits DNA repair. Unlike other fusion-driven sarcomas, TFCP2-rearranged tumors exhibit genomic instability and signs of defective homologous recombination. DNA methylation profiling demonstrates a close relationship with undifferentiated sarcomas. In two patients, sarcoma was preceded by benign lesions carrying FUS-TFCP2, indicating stepwise sarcomagenesis. This study illustrates the potential of linking precision oncology with preclinical research to gain insight into the classification, pathogenesis, and therapeutic vulnerabilities of rare cancers.
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| 6. |
- Stenzinger, Albrecht, et al.
(författare)
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Trailblazing precision medicine in Europe : A joint view by Genomic Medicine Sweden and the Centers for Personalized Medicine, ZPM, in Germany
- 2022
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Ingår i: Seminars in Cancer Biology. - : Elsevier. - 1044-579X .- 1096-3650. ; 84, s. 242-254
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Tidskriftsartikel (refereegranskat)abstract
- Over the last decades, rapid technological and scientific advances have led to a merge of molecular sciences and clinical medicine, resulting in a better understanding of disease mechanisms and the development of novel therapies that exploit specific molecular lesions or profiles driving disease. Precision oncology is here used as an example, illustrating the potential of precision/personalized medicine that also holds great promise in other medical fields. Real-world implementation can only be achieved by dedicated healthcare connected centers which amass and build up interdisciplinary expertise reflecting the complexity of precision medicine. Networks of such centers are ideally suited for a nation-wide outreach offering access to precision medicine to patients independent of their place of residence. Two of these multicentric initiatives, Genomic Medicine Sweden (GMS) and the Centers for Personalized Medicine (ZPM) initiative in Germany have teamed up to present and share their views on core concepts, potentials, challenges, and future developments in precision medicine. Together with other initiatives worldwide, GMS and ZPM aim at providing a robust and sustainable framework, covering all components from technology development to clinical trials, ethical and legal aspects as well as involvement of all relevant stakeholders, including patients and policymakers in the field.
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