| 4. |
- Buunen, M, et al.
(författare)
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COLOR II. A randomized clinical trial comparing laparoscopic and open surgery for rectal cancer.
- 2009
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Ingår i: Danish medical bulletin. - 1603-9629 .- 0907-8916. ; 56:2, s. 89-91
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: Laparoscopic resection of rectal cancer has been proven efficacious but morbidity and oncological outcome need to be investigated in a randomized clinical trial. Trial design: Non-inferiority randomized clinical trial. METHODS: The COLOR II trial is an ongoing international randomized clinical trial. Currently 27 hospitals from Europe, South Korea and Canada are including patients. The primary endpoint is loco-regional recurrence rate three years post-operatively. Secondary endpoints cover quality of life, overall and disease free survival, post-operative morbidity and health economy analysis. RESULTS: By July 2008, 27 hospitals from the Netherlands, Belgium, Germany, Sweden, Spain, Denmark, South Korea and Canada had included 739 patients. The intra-operative conversion rate in the laparoscopic group was 17%. Distribution of age, location of the tumor and radiotherapy were equal in both treatment groups. Most tumors are located in the mid-rectum (41%). CONCLUSION: Laparoscopic surgery in the treatment of rectal cancer is feasible. The results and safety of laparoscopic surgery in the treatment of rectal cancer remain unknown, but are subject of interim analysis within the COLOR II trial. Completion of inclusion is expected by the end of 2009. Trial registration: Clinicaltrials.gov, identifier: NCT00297791 (www.clinicaltrials.gov).
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| 5. |
- Tafoya, D., et al.
(författare)
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Detection of HCO+ emission toward the planetary nebula K3-35
- 2007
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Ingår i: Astronomical Journal. - 1538-3881 .- 0004-6256. ; 133:2, s. 364-369
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Tidskriftsartikel (refereegranskat)abstract
- We report the detection, for the first time, of HCO+(J = 1 -> 0) emission, as well as marginal CO(J = 1 -> 0) emission, toward the planetary nebula (PN) K3-35 as a result of a molecular survey carried out toward this source. We also report new observations of the previously detected CO( J 2 ! 1) and water maser emission, as well as upper limits for the emission of the SiO, (HCO+)-C-13, HNC, HCN, HC3OH, HC5N, CS, HC3N, (CO)-C-13, CN, and NH3 molecules. From the ratio of CO(J = 2 -> 1) to CO(J = 1 -> 0) emission we have estimated the kinetic temperature of the molecular gas, obtaining a value of similar or equal to 20 K. Using this result we have estimated a molecular mass for the envelope of similar or equal to 0.017M(circle dot) and an HCO+ abundance relative to H-2 of 6 x 10(-7), similar to the abundances found in other PNe. K3-35 is remarkable because it is one of the two PNe reported to exhibit water maser emission, which is present in the central region, as well as at a distance of similar or equal to 5000 AU from the center. The presence of molecular emission provides some clues that could help in understanding the persistence of water molecules in the envelope of K3-35. The HCO+ emission could be arising in dense molecular clumps, which may provide the shielding mechanism that protects water molecules in this source.
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