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- Webb, Thomas R., et al.
(författare)
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Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease
- 2017
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Ingår i: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097 .- 1558-3597. ; 69:7, s. 823-836
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show pleiotropy; that is, they are also associated with other diseases or traits.OBJECTIVES This study sought to systematically test if genetic variants identified for non-CAD diseases/traits also associate with CAD and to undertake a comprehensive analysis of the extent of pleiotropy of all CAD loci.METHODS In discovery analyses involving 42,335 CAD cases and 78,240 control subjects we tested the association of 29,383 common (minor allele frequency >5%) single nucleotide polymorphisms available on the exome array, which included a substantial proportion of known or suspected single nucleotide polymorphisms associated with common diseases or traits as of 2011. Suggestive association signals were replicated in an additional 30,533 cases and 42,530 control subjects. To evaluate pleiotropy, we tested CAD loci for association with cardiovascular risk factors (lipid traits, blood pressure phenotypes, body mass index, diabetes, and smoking behavior), as well as with other diseases/traits through interrogation of currently available genome-wide association study catalogs.RESULTS We identified 6 new loci associated with CAD at genome-wide significance: on 2q37 (KCNJ13-GIGYF2), 6p21 (C2), 11p15 (MRVI1-CTR9), 12q13 (LRP1), 12q24 (SCARB1), and 16q13 (CETP). Risk allele frequencies ranged from 0.15 to 0.86, and odds ratio per copy of the risk allele ranged from 1.04 to 1.09. Of 62 new and known CAD loci, 24 (38.7%) showed statistical association with a traditional cardiovascular risk factor, with some showing multiple associations, and 29 (47%) showed associations at p < 1 x 10(-4) with a range of other diseases/traits.CONCLUSIONS We identified 6 loci associated with CAD at genome-wide significance. Several CAD loci show substantial pleiotropy, which may help us understand the mechanisms by which these loci affect CAD risk.
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| 2. |
- Claesson, Urban, 1969-
(författare)
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Folkhemmets kyrka : Harald Hallén och folkkyrkans genombrott. En studie av socialdemokrati, kyrka och nationsbygge med särskild hänsyn till perioden 1905-1933
- 2004
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis explores aspects of what happened to the state Church of Sweden during the rise of the importance of public opinion and the evolution of the democratic nation state. Denmark provides the most well known Nordic example of how an old state Church became a democratic Folk (i.e. National) Church during this general transition. By comparing the Swedish with the Danish case, this study elucidates the less well known Folk Church ideology in Sweden. In Denmark a strong agrarian movement influenced by revivalism managed to take hold of public opinion making the state Church a part of the Danish national identity. Such a movement never appeared in the more industrialised Sweden. Instead a secular working class movement took hold of public and national opinion. The investigation is focused upon Harald Hallén (1884-1967), a pastor and a Social Democratic Member of Parliament. Lacking the revival elements of the Danish nationalism Hallén found that in order to get a Folk Church accepted within the secular Working class movement, it had to rest upon the heritage of the Enlightenment. Hallén regarded the Church as an expression of common ethical values within the Swedish nation. The Folk Church was supposed to strengthen existing ideals for a righteous socialist society by delivering the message of the Kingdom of God. Hallén strove to make the Church more democratic in order to express this ethical folk religion. Social Democratic nationalism became the dominant factor in Swedish political life between 1905 and 1933. The period was characterised by conflicts. First Hallén and those whom he represented fought against the Youth Church movement, which strove to establish another Folk Church ideology, by supporting the Swedish King against the rise of political Democracy. Later on, within his own Social Democratic party, Hallén fought his battle against the Marxist view of the state Church as a simple reflection of the dominant class. Hallén was in line with the political development, which resulted in a period of solid Social Democratic nation building from the 1930s onwards. From that decade on the Folk Church ideology of Hallén was established.
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| 3. |
- Ekberg, Mayvor
(författare)
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Se människan! : en studie av Luleå stifts möte med den moderna kulturen under 1900-talets första hälft
- 2004
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The present study deals with the encounter between the diocese of Luleå and the process of modernising. The main issue is individualism as a part of modern man’s identity. What kind of individualism was it, and how did it find expression in the diocese’s perspective on faith during the first half of the 20th century? A leading idea in the thesis is that the low church profile provided the diocese with a particular readiness to meet the demands of modern culture. The starting-point of the study is Philosopher Charles Taylor’s theory on the rise of modernity’s concept of freedom and perception of the self, which includes a justification of a positive side of modern individualism and a corresponding dismissal of a negative side. This attitude opens the door for the possibility of doing greater justice to the low church emphasis on the individual person. Taylor asks, from his moral-philosophical point of view, as well as the diocese of Luleå did, whether the Christian faith would have any future in modern culture. The low church view on faith becomes dynamic-extential as it dismisses a traditional metaphysical or theoretical explanation of God as a transcendent reality. Instead the subject is given vital importance. This apprehension reflects an influence from expressivism as a new form of consciousness, in protest against the science of the 17th that separated reason from both nature and feelings. This was inherent in the diocese via pietism. However, not an outspoken anthropology, the diocese nevertheless indicates that it considers man a linguistic and self-interpreting creature. This amounts to a more suitable view on the belief in modern culture, which no longer can rely on a commonly accepted belief in an inherent order of the world as an expression of God’s intentions and will.
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| 4. |
- Franzén, Ruth
(författare)
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Anders Jarlert och Samuel Rubenson, Kyrkohistoria i Lund : fyra föreläsningar
- 2001
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Ingår i: Kyrkohistorisk Årsskrift. - 0085-2619. ; 101, s. 160-162
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Recension (populärvet., debatt m.m.)abstract
- De fyra provföreläsningar som är samlade i skriften är underlag för reflexioner kring olika presentationer av disciplinen, dess funktion och roll som akademiskt läroämne. Recensenten konstaterar att den lilla skriften ger många incitament att fundera vidare i ämnesteoretiska frågor.
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| 8. |
- Franzén, Ruth
(författare)
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Att förhandla sitt medborgarskap (recension)
- 2002
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Ingår i: kyrkohistorisk årsskrift 2002. - : Uppsala, Svenska kyrkohistoriska föreningen. - 9185582492 ; 1:102, s. 193-196
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Recension (övrigt vetenskapligt/konstnärligt)
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